在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NQO2 Antibody, Biotin conjugated

  • 中文名稱:
    NQO2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA016040LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NQO2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NQO2
  • 別名:
    DHQV antibody; DIA6 antibody; EC 1.10.99.2 antibody; MGC94180 antibody; NAD(P)H dehydrogenase quinone 2 antibody; NAD(P)H menadione oxidoreductase 1 dioxin inducible 2 antibody; NAD(P)H menadione oxidoreductase 2 dioxin inducible antibody; NMOR2 antibody; NQO 2 antibody; NQO2 antibody; NQO2_HUMAN antibody; NRH dehydrogenase [quinone] 2 antibody; NRH dehydrogenase antibody; NRH:quinone oxidoreductase 2 antibody; OTTHUMP00000015948 antibody; OTTHUMP00000015949 antibody; OTTHUMP00000015953 antibody; Ox 2 antibody; Ox2 antibody; QR2 antibody; Quinone antibody; Quinone reductase 2 antibody; Ribosyldihydronicotinamide dehydrogenase [quinone] antibody; Ribosyldihydronicotinamide dehydrogenase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ribosyldihydronicotinamide dehydrogenase [quinone] protein (1-231AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
  • 基因功能參考文獻:
    1. The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). PMID: 28346733
    2. In patients with Alzheimer's disease, QR2 is overexpressed in the insular cotex. PMID: 26609153
    3. NQO2-L47 is less stable towards proteolytic digestion and thermal denaturation than NQO2-F47. PMID: 24631540
    4. NQO1 609C>T and NQO2 -3423G>A polymorphisms do not seem to play any significant role in susceptibility or prognosis of EC in north Indian population. PMID: 22770696
    5. This first structure of a reduced quinone reductase shows that reduction of the FAD cofactor and binding of a specific inhibitor lead to global changes in NQO2 structure and is consistent with a functional role for NQO2 as a flavin redox switch. PMID: 23471972
    6. both NQO1 and NQO2 modulate the efficacy of AC therapy and that NQO2 is associated with tamoxifen toxicity. PMID: 21946896
    7. results indicate a role of NQO2 in the control of AKT/GSK-3beta/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol PMID: 22266466
    8. Results suggest that NQO2, SOD2 and SOD3 may significantly modify prognosis of breast cancer patients. PMID: 21351093
    9. results suggest that the increase in hippocampal QR2 might be a cause of AD or might promote the progression of AD by causing an increase in the toxic quinone levels and consequent loss of cognitive function. PMID: 21803122
    10. Selective inhibition of NQO2 over NQO1 can be attributed to the bulky aminoalkylamino substituent at the 5-position, which blocks entrance of the indolequinones into the NQO1 active site. PMID: 21718050
    11. NQO2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    12. The NQO1 609C>T TT genotype and T allele were significantly associated with increased risk for gastric cancer (GC), whereas NQO2 -3423G>A polymorphism did not show any association with GC. PMID: 21294640
    13. The first European study of the SOD2, SOD3, NQO1, and NQO2 roles in pancreatic cancer etiology did not find significant associations. PMID: 20966810
    14. We observed a nominal significant association between the rs1143684 NQO2 polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities. PMID: 18538895
    15. Our findings challenge the previous assumption that the NQo2 I-16 allele is stable only when paired with another I-16 allele PMID: 19495956
    16. polymorphisms associated with idiopathic Parkinson's disease PMID: 11688992
    17. A significant difference was found between alcoholic patients and controls in genotype frequency at an insertion/deletion site in the promoter region of the NQO2 gene (p = 0.0014). PMID: 12960511
    18. the level of NQO2 mRNA is low in AGR patients compared with the control group. Such a reduction in message suggests that the NQO2 gene may be involved in the development of clozapine-induced AGR. PMID: 14617031
    19. NQO2 gene may confer susceptibility to a certain form of schizophrenia. PMID: 14639047
    20. the NQO2 gene is differentially expressed by the polymorphic promoters in human cells transfected with NQO2 gene reporter constructs. Alterations in NQO2 activity might be an important factor in susceptibility to Parkinson's disease. PMID: 15451063
    21. We propose that induction of NQO2 may relate to the observed increased expression of p53 that, in turn, contributes to the observed suppression of cell growth in both melanoma cell lines. PMID: 15993843
    22. the nicotinamide adenine dinucleotide phosphate reduced-diaphorase interneurons in the human striatum. PMID: 16025450
    23. The results combined demonstrated that Nrf2 associates with JunD, binds to ARE at nucleotide -1433, and regulates human NQO2 gene expression and induction in response to antioxidants. PMID: 16545679
    24. an apparent association between an NQO2 exon 3 single-nucleotide polymorphism and lower enzymatic activity PMID: 17332305
    25. The crystal structure of melatonin and 2-iodomelatonin in complex with QR2 provide a detailed description of the enzyme active site; the design of inhibitors of the enzyme might be instrumental in discriminating the role of MT1, MT2 and QR2/MT3 PMID: 18254726
    26. Parkinson's disease patients were analyzed for NQO2 gene promoter polymorphisms. Three allelic variants were I-29, I-16 and D. The association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene. PMID: 18314446
    27. This first structural analysis of hQR2 should enable to better understand the biological role of melatonin on this enzyme . PMID: 18502195
    28. Quinone reductase 2 is a catechol quinone reductase. quinone reductase 2 could play important roles in the regulation of catecholamine oxidation processes that may be involved in the etiology of Parkinson disease. PMID: 18579530
    29. nmr studies of QR2 catalytic reaction were performed; results led to conclusion that melatonin is not cleaved to form N1-acetyl-N2-formyl-5-methoxykynurenine by a catalytically active QR2, indicating melatonin is neither a substrate nor a co-substrate PMID: 18826489
    30. NQO2 is a susceptibility gene for breast carcinogenesis. PMID: 19351655

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    NAD(P)H dehydrogenase (quinone) family
  • 數據庫鏈接:

    HGNC: 7856

    OMIM: 160998

    KEGG: hsa:4835

    STRING: 9606.ENSP00000337773

    UniGene: Hs.533050



主站蜘蛛池模板: 无码国产69精品久久久久网站| 国产精品无码a∨果冻传媒| 免费人成黄页在线观看国产| 久久ww精品w免费人成| 全部孕妇毛片丰满孕妇孕交| 亚洲综合国产一区二区三区| 中文字幕+乱码+中文乱码www| 国产成人啪精品视频网站午夜 | 国产网红无码精品视频| 亚洲第一综合天堂另类专| 电影内射视频免费观看| 亚洲自偷自偷偷色无码中文| 天美麻花果冻视频大全英文版 | 亚洲国产精品无码专区成人| 女女女女女裸体处开bbb| 无码人妻一区二区三区免费看| 国产激情无码视频在线播放| 日本两人免费观看的视频| 国产成人午夜福利免费无码r| 久久久久亚洲精品| 免费无码毛片一区二三区| 伊人情人色综合网站| 亚洲乱码一卡二卡卡3卡4卡| 亚洲乱码一区av春药高潮| 猫咪www免费人成人入口| 真实国产乱子伦对白视频不卡| av片日韩一区二区三区在线观看| 欧洲av无码放荡人妇网站| 亚洲综合无码一区二区三区| 99精品热这里只有精品| 国产精品玖玖玖在线| 四虎影视在线影院在线观看免费视频| 欧洲熟妇色 欧美| 9久9久女女热精品视频在线观看| 免费很黄无遮挡的视频| 国产精品亚洲lv粉色| 国产99视频精品免视看9| 国内少妇高潮嗷嗷叫在线播放| 996热re视频精品视频这里| 蜜臀av一区二区| 久久久噜噜噜久久熟女 |