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NPTX1 Antibody

  • 中文名稱：
    NPTX1兔多克隆抗體
  • 貨號：
    CSB-PA614901LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA614901LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA614901LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NPTX1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Neuronal pentraxin I antibody; Neuronal pentraxin-1 antibody; NP 1 antibody; NP-I antibody; NP1 antibody; Nptx1 antibody; NPTX1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Neuronal pentraxin-1 protein (88-227AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，NPTX1 Antibody (CSB-PA614901LA01HU)，的標(biāo)記方式是Non-conjugated。對于NPTX1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA614901LB01HU NPTX1 Antibody, HRP conjugated ELISA
    FITC CSB-PA614901LC01HU NPTX1 Antibody, FITC conjugated
    Biotin CSB-PA614901LD01HU NPTX1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
  • 基因功能參考文獻：
    1. NPTX1 is down-regulated in colon cancer. In addition, NPTX1 inhibits the proliferation of colon cancer cells via decreasing cyclin A2 and CDK2. PMID: 29345391
    2. NPTX1 was significantly associated with bipolar disorder. PMID: 25053281
    3. findings suggest that lower NARP mRNA expression contributes to lower excitatory drive onto parvalbumin interneurons in schizophrenia. PMID: 26038830
    4. These results suggest that NPTX1 hypermethylation and consequent mRNA changes might be an important molecular mechanism in lung cancer. PMID: 25646694
    5. Taken together, these results demonstrate that NP1 gene is a target of as hypoxia inducible factor-1 alpha and it regulates NP1 expression by binding to hypoxia responsive elements in its promoter region. PMID: 25498504
    6. Long acting progestin contraceptive-enhanced NPTX1 secretion and reactive oxygen species generation in endometrial stromal cells impair endometrial endothelial cells survival resulting in a loss in vascular integrity. PMID: 25029423
    7. NPTX1 binds and inhibits TDGF1, and reduces both Nodal and BMP signaling. PMID: 24529709
    8. Neuronal pentraxin 1 transgene is a key factor for the synapse loss, the neurite damage, and the apoptotic neuronal death evoked by amyloid-beta protein, which regulates NP1 expression. PMID: 17151277
    9. The purpose of the present study was to assess the toxic effect of taipoxin in SCLC-cell lines and to determine if toxicity correlates to NPR and NP1 and NP2 expression levels. PMID: 16115696

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  • 亞細胞定位：
    Cytoplasmic vesicle, secretory vesicle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7952

    OMIM: 602367

    KEGG: hsa:4884

    STRING: 9606.ENSP00000307549

    UniGene: Hs.514556



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