在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NOXO1 Antibody, HRP conjugated

  • 中文名稱:
    NOXO1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA015964LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NOXO1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NOXO1
  • 別名:
    NADPH oxidase organizer 1 antibody; NADPH oxidase regulatory protein antibody; Nox organizer 1 antibody; Nox organizing protein 1 antibody; Nox-organizing protein 1 antibody; NOXO1 antibody; NOXO1_HUMAN antibody; P41NOX antibody; Regulatory protein P41NOX antibody; SH3 and PX domain-containing protein 5 antibody; SH3PXD5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human NADPH oxidase organizer 1 protein (304-376AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
  • 基因功能參考文獻:
    1. PEDF protects human glomerular mesangial cells from diabetes-derived oxidative stress via NOXO1- iNOS suppression. PMID: 28944893
    2. Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region. PMID: 28625920
    3. TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. PMID: 23975421
    4. Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1, an interaction that participates in Nox1 activation PMID: 23957209
    5. Phorbol myristate acetate stimulates NOXO1 phosphorylation in a transfected human embryonic kidney (HEK) 293 epithelial cell model via protein kinase C and identify Ser-154 as the major phosphorylated site. PMID: 23322165
    6. Surface plasmon resonance experiments identify PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as preferred targets of NOXO1beta PX. PMID: 22342885
    7. The backbone assignments of NOXO1beta PX are studied using NMR. PMID: 21188560
    8. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented. PMID: 20454568
    9. NOXO1 and NOXA1 activate Nox1 without the need for agonist activation, and this is mediated in part by binding of the NOXO1 PX domain to membrane lipids. PMID: 14617635
    10. NOXO1, p47phox, and p67phox regulate Nox3 PMID: 15181005
    11. Data suggest different tissue localizations and functions for NOXO1beta and NOXO1gamma in regulating Nox family members. PMID: 15949904
    12. These results suggest that the formation of the complex consisting of Nox1, betaPix, and NoxO1 is likely to be a critical step in EGF-induced ROS generation. PMID: 16329988
    13. This study shows the expression of alternatively spliced transcripts of the NOXO1 gene and the roles of the protein products in the activation of Nox oxidases. PMID: 16911517
    14. These findings suggest that Nox activation involves a conformational change leading to disruption of the bis-SH3-PRR interaction in Noxo1. PMID: 17126813

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).
  • 組織特異性:
    Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
  • 數據庫鏈接:

    HGNC: 19404

    OMIM: 611256

    KEGG: hsa:124056

    STRING: 9606.ENSP00000380450

    UniGene: Hs.191762



主站蜘蛛池模板: 亚洲无线观看国产精品| 无码av最新高清无码专区| 偷柏自拍亚洲综合在线| 熟妇高潮精品一区二区三区| 无码成a毛片免费| 天天躁夜夜躁狠狠眼泪| yy111111少妇无码理论片| 无码吃奶揉捏奶头高潮视频| 国产人妻xxxx精品hd| 7777色鬼xxxx欧美色妇| 窝窝午夜看片| 黄a无码片内射无码视频| 51久久成人国产精品麻豆| 国产精品色情国产三级在| 不卡无码人妻一区二区三区| 国产人妻久久精品一区二区三区| 在线亚洲人成电影网站色www| 国产午夜福利在线观看红一片| 伊人大香人妻在线播放| 狼友网精品视频在线观看 | 久久久久麻豆v国产精华液好用吗| 国产看黄网站又黄又爽又色| 996久久国产精品线观看| 亚洲αv无码一区二区三区四区| 男女做爰猛烈啪啪吃奶伸舌头下载 | 亚洲精品欧美二区三区中文字幕| 午夜精品久久久久久久爽| 精品高朝久久久久9999| 国产精品无码久久四虎| 色婷婷亚洲一区二区三区| 久久精品中文字幕大胸| 国产萌白酱喷水视频在线播放| 在线播放亚洲人成电影| 国产精品久久久久久超碰 | 九九线精品视频在线观看| 欧美色欧美亚洲高清在线视频| 国产av成人一区二区三区| 亚洲aⅴ无码国精品中文字慕| 极品国产主播粉嫩在线 | 熟妇人妻系列av无码一区二区| 欧美丰满妇大ass|