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  4. NOVA1 Antibody, Biotin conjugated

NOVA1 Antibody, Biotin conjugated

  • 中文名稱：
    NOVA1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA015957LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NOVA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NOVA1
  • 別名：
    Neuro oncological ventral antigen 1 antibody; Neuro-oncological ventral antigen 1 antibody; NOVA 1 antibody; Nova-1 antibody; Nova1 antibody; NOVA1_HUMAN antibody; Onconeural ventral antigen 1 antibody; Paraneoplastic Ri antigen antibody; RNA binding protein Nova 1 antibody; RNA-binding protein Nova-1 antibody; Ventral neuron specific protein 1 antibody; Ventral neuron-specific protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human RNA-binding protein Nova-1 protein (6-174AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons. Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Autoregulates its own expression by acting as a splicing repressor. Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord.
  • 基因功能參考文獻：
    1. It regulates the alternative splicing of estrogen receptor beta in the aging brain. PMID: 29031089
    2. overexpression of miR-203a-3p leads to a decrease of NOVA1, counter-balanced by an increase of IKAP, supporting a potential interaction between NOVA1 and IKAP. PMID: 27483351
    3. NOVA1 suppression was frequently noted in the gastric cancer microenvironment, and attenuated NOVA1 expression in tumor cells was associated with tumor progression and poor prognosis. PMID: 27318497
    4. Nova1 interacts with GABAARgamma2 not only in the central nervous system but also in hepatocellular carcinoma. Nova1's potential mechanism as an oncogene may due to its interaction with GABAA Rgamma2. PMID: 27733149
    5. Loss of NOVA1 is associated with gastric cancer. PMID: 26673617
    6. Quantitative proteomic analysis was performed to help elucidate a molecular distinction between glioblastoma and oligodendroglioma; analysis showed HSPB1 and NOVA1 to be discriminating factors. PMID: 26108672
    7. Data indicate RNA binding protein NOVA1 as a target of microRNA miR-339. PMID: 26391641
    8. MiR-181b-5p is a tumor suppressor in astrocytoma that inhibits tumor progression by targeting NOVA1. PMID: 25299073
    9. High expression of NOVA1 correlates with poor prognosis in hepatocellular carcinoma. PMID: 24608171
    10. a regulation of LEDGF interaction with chromatin by cellular partners of its PWWP domain could be involved in several processes linked to LEDGF tethering properties, such as lentiviral integration, DNA repair or transcriptional regulation PMID: 24312278
    11. Gene silencing and overexpression of the nELAV member HuD in motoneuronal NSC34 cells indicate that Nova1 mRNA stability and translation are positively and strongly controlled by the nELAV proteins PMID: 18218628
    12. Semiquantitative estimation of circulating anti-Ri antibodies demonstrated a renewed increase in antibody levels preceding relapse of the cancer, as confirmed using F-fluorodeoxyglucose positron emission tomography (FDG-PET) PMID: 18822086

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in cerebellum, brain stem, hippocampus, and frontal cortex.
  • 數據庫鏈接：

    HGNC: 7886

    OMIM: 602157

    KEGG: hsa:4857

    STRING: 9606.ENSP00000438875

    UniGene: Hs.31588



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