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  4. NOP56 Antibody

NOP56 Antibody

  • 中文名稱：
    NOP56兔多克隆抗體
  • 貨號(hào)：
    CSB-PA384993
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HEPG2 Hela cells using NOP56 Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NOP56
  • 別名：
    NOP56 antibody; NOL5ANucleolar protein 56 antibody; Nucleolar protein 5A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from NOP56 at AA range: 191-240
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-2000
    ELISA 1:10000-20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.
  • 基因功能參考文獻(xiàn)：
    1. Genetic and clinical analysis of spinocerebellar ataxia type 36 in Mainland China, with its causative mutation as a hexanucleotide GGCCTG repeat expansion in intron 1 of the NOP56 gene, has been described. PMID: 26661328
    2. Studies indicate that the causative mutation for spinocerebellar ataxias SCA36, namely intronic hexanucleotide GGCCTG expansion in NOP56 gene, has been identified. PMID: 26663071
    3. We newly found intronic hexanucleotide GGCCTG gene expansion in NOP56 gene as the causative mutation in nine unrelated Japanese familial hereditary spinocerebellar ataxia patients PMID: 22353375
    4. This study demonistrated that NOP56 mutation is response spinocerebellar ataxia 36 in Spainish family. PMID: 22492559
    5. Expansion of the intronic GGCCTG hexanucleotide repeat in NOP56 causes a unique form of spinocerebellar ataxias, SCA36, which shows not only ataxia but also motor neuron dysfunction. PMID: 21683323
    6. hNop56p functions in the early to middle stages of 60 S subunit synthesis in human cells and has functional similarities with treacle-associated ribonucleoproteins PMID: 12777385
    7. Data demonstrate that fibrillarin and Nop56 directly interact in vivo, and that this interaction is indispensable for the association of both proteins with the box C/D snoRNPs. PMID: 19331828
    8. snoRNP assembly factor NUFIP can regulate the interactions between TIP48 and TIP49 and the core box C/D proteins. PMID: 19620283

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  • 相關(guān)疾病：
    Spinocerebellar ataxia 36 (SCA36)
  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Cytoplasm. Nucleus, nucleoplasm.
  • 蛋白家族：
    NOP5/NOP56 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15911

    OMIM: 614153

    KEGG: hsa:10528

    STRING: 9606.ENSP00000370589

    UniGene: Hs.376064



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