在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NNT Antibody

  • 中文名稱:
    NNT兔多克隆抗體
  • 貨號:
    CSB-PA015908GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NNT
  • 別名:
    GCCD4 antibody; mitochondrial antibody; NAD(P) transhydrogenase antibody; NAD(P) transhydrogenase mitochondrial antibody; Nicotinamide nucleotide transhydrogenase antibody; NNT antibody; NNTM antibody; NNTM_HUMAN antibody; Pyridine nucleotide transhydrogenase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NNT
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.
  • 基因功能參考文獻:
    1. Overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. Knockdown of NNT caused significantly NADPH reduction, induced high levels of Reactive Oxygen Species and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. PMID: 30059901
    2. Findings suggest that NNT is essential to homeostasis of NADH and NADPH pools, anomalies of which affect HIF-1alpha- and HDAC1-dependent pathways, and hence retrograde response of mitochondria. PMID: 28478381
    3. Study describes the fi rst structural model of the human NNT. The 3D model identifies functional and structural H-NNT key motifs and gain essential insight into the structural and functional effect of deleterious amino acid substitutions causing glucocorticoid de fi ciency and LVNC cardiomyopathy, as well as rare homozygote amino acid variations. PMID: 27459240
    4. NNT should be sequenced in all primary adrenal insufficiencies for which the most frequent etiologies have been ruled out. As NNT is involved in oxidative stress, careful follow-up is needed to evaluate mineralocorticoid biosynthesis extent, and gonadal, heart and thyroid function. PMID: 27129361
    5. identified a 6.67 Mb homozygous region harboring the NNT gene in a Dutch patient presenting with familial glucocorticoid deficiency (FGD); a novel homozygous mutation (NM_012343.3: c.1259dupG) in NNT was revealed; reviewed the literature for all the reported NNT mutations and their clinical presentation PMID: 26548497
    6. This report of a novel NNT mutation, p.G200S, expands the phenotype of NNT mutations to include mineralocorticoid deficiency. It provides the first evidence that NNT mutations can cause oxidative stress and mitochondrial defects. PMID: 26070314
    7. Data suggest mutations in nicotinamide nucleotide transhydrogenase (NNT) as contributory to left ventricular noncompaction (LVNC). PMID: 26025024
    8. NNT mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin. PMID: 23592659
    9. Results suggest that NNT may have a role in ROS detoxification in human adrenal glands. PMID: 22634753
    10. In the failing heart a partial loss of Nnt activity adversely impacts NADPH-dependent enzymes and the capacity to maintain membrane potential, thus contributing to a decline in bioenergetic capacity, redox regulation and antioxidant defense. PMID: 20388492
    11. the expression of the transhydrogenase gene in subsections of the human brain showed a distribution that apparently varied as a function of neuronal density PMID: 12223207

    顯示更多

    收起更多

  • 相關疾病:
    Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency (GCCD4)
  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
  • 蛋白家族:
    AlaDH/PNT family; PNT beta subunit family
  • 組織特異性:
    Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.
  • 數據庫鏈接:

    HGNC: 7863

    OMIM: 607878

    KEGG: hsa:23530

    STRING: 9606.ENSP00000264663

    UniGene: Hs.482043



主站蜘蛛池模板: av蓝导航精品导航| 日本高清在线一区二区三区| 中文字幕人成乱码熟女app| 国产日产欧产精品精品推荐免费| 国产成人一区二区无码不卡在线| 久久综合婷婷丁香五月中文字幕| 久久综合九色综合欧美98| 快好爽射给我视频| 成年无码av片在线免缓冲| 久久久精品94久久精品| 无码熟妇人妻av| 亚洲无线观看国产精品| 亚洲精品无码成人片久久| 99久久er热在这里只有精品99| 欧美性猛交xxxx免费看蜜桃| av中文字幕潮喷人妻系列| 日韩精品亚洲人旧成在线| 亚洲男人天堂| 少妇真实被内射视频三四区| 亚洲国产一区二区三区在观看| 亚洲中字幕日产av片在线| 亚瑟国产精品久久| 成人av片无码免费网站| 亚洲综合精品第一页| 免费国产线观看免费观看| 久久亚洲精精品中文字幕| 久久精品国产福利一区二区| 亚洲日韩a∨无码久| 国产日韩在线视看第一页| 国产人妻精品一区二区三区| 中文av岛国无码免费播放| 强制高潮18xxxxhd日韩| av免费网址在线观看| 亚洲aⅴ无码国精品中文字慕 | 久久久久人妻一区精品色欧美| 欧洲亚洲1卡二卡三卡2021| 欧美人成精品网站播放| 精品深夜av无码一区二区| 国产午费午夜福利200集| 人妻熟女久久久久久久| 少妇高潮毛片免费看|