在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NMU Antibody

NMU Antibody

  • 中文名稱：
    NMU兔多克隆抗體
  • 貨號：
    CSB-PA015902ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA015902ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NMU Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NMU
  • 別名：
    Neuromedin U 25 antibody; Neuromedin U antibody; Neuromedin-U-25 antibody; NmU 25 antibody; NMU antibody; NmU-25 antibody; NMU_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Neuromedin-U protein (35-174AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
  • 基因功能參考文獻：
    1. Results identified NMU as highly expressed in non-small cell lung cancer (NSCLC) tissues and cell lines. Furthermore, integrative bioinformatics analyses demonstrate that NMU may confer the alectinib resistance in NSCLC via multiple mechanisms. PMID: 30096454
    2. NMU might contribute to progression of NMUR2-positive breast cancer PMID: 28423716
    3. The anti-tumorigenic effect of HAND2-AS1 in endometrioid endometrial carcinoma was mediated by down-regulating neuromedin U expression. PMID: 29107108
    4. Results indicate a mechanism of action for neuromedin U (NmU) in HER2-overexpressing breast cancer that enhances resistance to HER2-targeted drugs through conferring cancer stem cell (CSC) characteristics and expansion of the CSC phenotype. PMID: 28340506
    5. This study shows an association between a NMU haplotype and anthropometric indices, mainly linked to fat mass, which appears to be age- and sex-specific in children. PMID: 28235053
    6. Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC. PMID: 27279246
    7. polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. PMID: 25871004
    8. our results defined NmU as a candidate drug response biomarker for HER2-overexpressing cancers and as a candidate therapeutic target to limit metastatic progression and improve the efficacy of HER-targeted drugs. PMID: 24876102
    9. a role for NMU gene through interaction with ADRB2 gene in bone strength regulation PMID: 23936460
    10. Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells. PMID: 21791076
    11. [review] Taken together with its vascular actions, NMU may be a functional link between energy balance and the cardiovascular system and may provide a future target for therapies directed against the disorders that comprise metabolic syndrome. PMID: 19519756
    12. These results suggest that NMU plays a role in feeding behavior and catabolic functions via corticotropin-releasing hormone. PMID: 14623274
    13. NmU expression is related to Myb and that the NmU/NMU1R axis constitutes a previously unknown growth-promoting autocrine loop in myeloid leukemia cells PMID: 15187020
    14. irreversible binding of NmU to its receptors PMID: 15331768
    15. Overexpression of neuromedin U is associated with bladder tumor formation, lung metastasis and cancer cachexia PMID: 16878152
    16. Amino acid variants in NMU associate with overweight and obesity, suggesting that NMU is involved in energy regulation in humans. PMID: 16984985
    17. NMU & its cancer-specific receptors, as well as its target genes, are frequently overexpressed in clinical samples of lung cancer and in cell lines, and that those gene products play indispensable roles in the growth and progression of lung cancer cells. PMID: 17018595
    18. NmU may be involved in the HGF-c-Met paracrine loop regulating cell migration, invasiveness and dissemination of pancreatic ductal adenocarcinoma. PMID: 19118941

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    NmU family
  • 組織特異性：
    Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7859

    OMIM: 605103

    KEGG: hsa:10874

    STRING: 9606.ENSP00000264218

    UniGene: Hs.418367



主站蜘蛛池模板： 天堂资源中文| 潮喷大喷水系列无码久久精品| av天堂午夜精品蜜臀av| 欧美极品少妇×xxxbbb| 四房播播开心五月| 中文日产乱幕九区无线码| 96亚洲精华国产精华精华液| 婷婷五月小说| 狠狠色噜噜狠狠狠777米奇小说| 色欲人妻aaaaaa无码| 国产人成午夜免电影费观看| 绝顶高潮合集videos| 波多野42部无码喷潮在线| 精品国产一区二区三区国产区| 女厕厕露p撒尿八个少妇| 久久精品中文字幕| 亚洲日韩欧洲无码av夜夜摸| 亚洲 小说 欧美 另类 社区| 亚洲精品www久久久| 久久久久久久极品内射| 蜜乳av久久久久久久久久久| 国产人成无码视频在线1000 | 国产免费艾彩sm调教视频| 精品久久久久久无码专区| 人人爽天天碰狠狠添| 久久99热久久99精品| а天堂中文地址在线| 97在线成人国产在线视频| 色午夜日本高清视频www| 丁香激情综合久久伊人久久| 丰满岳乱妇在线观看中字 | 搡老熟女老女人一区二区| 精品一区二区三人妻视频 | 午夜不卡无码中文字幕影院| 人妻有码av中文字幕久久琪| 国产末成年av在线播放| 亚洲免费视频免在线观看| 亚洲va久久久噜噜噜久久| 午夜私人成年影院| 日本高清无卡码一区二区 | 免费观看又色又爽又黄的崩锅|