在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NME2 Antibody

  • 中文名稱:
    NME2兔多克隆抗體
  • 貨號:
    CSB-PA015886GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NME2
  • 別名:
    C myc purine binding transcription factor PUF antibody; C myc transcription factor antibody; C-myc purine-binding transcription factor PUF antibody; epididymis secretory sperm binding protein Li 155an antibody; HEL-S-155an antibody; Histidine protein kinase NDKB antibody; MGC111212 antibody; MGC2212 antibody; NDK B antibody; NDKB antibody; NDKB_HUMAN antibody; NDP kinase B antibody; NDPK B antibody; NDPKB antibody; NM23 H2 antibody; nm23-H2 antibody; NM23B antibody; NME/NM23 nucleoside diphosphate kinase 2 antibody; nme2 antibody; Non metastatic cells 2; protein (NM23B) expressed in antibody; non-metastatic cells 2; protein (NM23) expressed in antibody; Nucleoside diphosphate kinase B antibody; Nucleotide diphosphate kinase B antibody; PUF antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NME2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity.
  • 基因功能參考文獻:
    1. Data suggest that NME2 participates in epigenetic repression of TERT expression via a mechanism that is dependent on interactions with G-quadruplex DNA; NME2 appears to interact with TERT promoter as NME2/REST/LSD1 complex. (NME2 = metastasis suppressor protein 2; TERT = telomerase reverse transcriptase; REST = RE1-silencing transcription factor; LSD1 = lysine specific demethylase 1) PMID: 28717007
    2. Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A PMID: 26950439
    3. NME2 may have an inhibitory activity on the propagation and invasion of gastric cancer cells. PMID: 25700270
    4. Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives PMID: 25413836
    5. Recent findings demonstrate NME2 presence at telomere ends, association with telomerase, and NME2's role in inhibition of telomerase activity in cancer cells PMID: 25547372
    6. A novel mechanism of CARMA3 in lung cancer stemness and metastasis through the negative regulation of NME2 was identified. PMID: 25906011
    7. NDPK-B and NDPK-D were shown to bind efficiently to liposomes mimicking plasma membrane and mitochondrial inner membrane PMID: 25010650
    8. Patients whose MPM tissues expressed elevated mRNA levels of BIRC5, DSP, NME2, and THBS2 showed a statistically significant shorter overall survival. PMID: 25771974
    9. The results demonstrate that reduced NME2 levels lead to transcriptional de-repression of vinculin and regulate lung cancer metastasis. PMID: 25249619
    10. nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca(2+) flux, and this activation requires histidine 711 in the carboxy-terminal tail of TRPV5. PMID: 24523290
    11. NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions. PMID: 25147336
    12. PuF may regulate the APP gene promoter PMID: 23368879
    13. post-transcriptional up-regulation of the tumor antigen NME2 is a common and specific property of CML closely associated with Bcr-Abl activity PMID: 22251158
    14. NM23-H2 expression enhances tumorigenicity. PMID: 22192927
    15. further demonstrate that shNDPK-B is released into the circulation in immunocompromized mice carrying the human breast carcinoma cell MDA-MB- PMID: 20830314
    16. Observational study of gene-disease association, gene-gene interaction, and genetic testing. (HuGE Navigator) PMID: 20864512
    17. NM23-H2 protein expression in human leukemia cell lines is related to cellular lineage and differentiation stages. PMID: 12007505
    18. The nucleotide-binding site of NM23-H2 plays a critical role in not only the NDP kinase reaction but also the reactions involving covalent DNA binding and DNA cleavage catalysis. PMID: 12009894
    19. Nm23-H2 had a cytoplasmic and nuclear localization but was induced to translocate to the plasma membrane upon stimulation of thromboxane A2 receptor beta to show extensive co-localization with the receptor. PMID: 14976202
    20. novel association of NM23-H2 with ERbeta and show for the first time its expression in vascular cells and demonstrate regulation of its expression and localization by estrogen PMID: 17272673
    21. Thus, these results indicate the existence of a previously undiscovered mechanism by which NM23-H2 involves in the regulation of Diva-mediated apoptosis. PMID: 17532299
    22. NM23-H2 as an estrogen receptor beta-associated protein may play an important role in modulating the response to endogenous and exogenous estrogens. PMID: 17964137
    23. describe the identification of NM23-H2 as a novel HLA-A32-restricted TAA of CML cells and demonstrate the presence of specifically reactive T cells in a patient 5 years after transplantation PMID: 18496563
    24. While hPLIC proteins are not ubiquitinated by HERC3, HERC5 plays an important role in ubiquitination of Nm23B. PMID: 18535780
    25. data indicate that NM23H2 is a negative regulator of cellular proliferation stimulated by EGF- and Ras-mediated activation of the ERK pathway PMID: 19022560
    26. Role of NM23-H2 in the regulation of cell shape and migration via Rho family GTPase signals is reported. PMID: 19381785
    27. Data support the hypothesis that exogenous pDNA binds to cytoplasmic shuttle proteins NM23-H2 and Chx10, and is then translocated to the nucleus using the minimal import machinery. PMID: 19638341

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle.
  • 蛋白家族:
    NDK family
  • 組織特異性:
    Isoform 1 and isoform 3 are ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 7850

    OMIM: 156491

    KEGG: hsa:4831

    STRING: 9606.ENSP00000376886

    UniGene: Hs.463456



主站蜘蛛池模板: 国产aⅴ爽av久久久久久| 亚洲精品无码人妻无码| 成av免费大片黄在线观看| 日本在线视频www色| 久久婷婷狠狠综合激情| 男人扒开女人内裤强吻桶进去 | 蜜桃网站入口可看18禁| 亚洲熟妇无码八av在线播放| 熟女人妇 成熟妇女系列视频| 亚洲精品久久久久中文字幕一福利| 国产有奶水哺乳期无码avav| 97在线视频人妻无码| 69综合精品国产二区无码| 真人一进一出120秒试看| 亚洲乱码日产一区三区| 中文在线中文资源| 国产激情з∠视频一区二区| 强行从后面挺进人妻| 国产亚洲综合欧美视频| 中国国产免费毛卡片| 中国少妇无码专区| 亚洲国产精品自产在线播放| 天天天狠天天碰天天爱| 爽爽午夜影视窝窝看片| 欧美极品少妇性运交| 国产一区二区不卡老阿姨| 自慰无码一区二区三区| 国产性色av一区二区三区| 无码av不卡免费播放| 久久综合给合久久狠狠狠88| 精品久久久久久综合日本| 97久久超碰亚洲视觉盛宴| 无码人妻丰满熟妇奶水区码| 性亚洲videofree高清| 亚洲综合另类小说色区色噜噜 | 亚洲精品久久区二区三区蜜桃臀| 无码国产伦一区二区三区视频| 久久狠狠色噜噜狠狠狠狠97| 亚洲成_人网站图片| 中文字幕有码无码人妻在线| 亚洲伊人久久综合成人|