在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NME1 Antibody

  • 中文名稱:
    NME1兔多克隆抗體
  • 貨號:
    CSB-PA003460
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using NM23-H1 Polyclonal Antibody
    • Western Blot analysis of 293T HELA cells using NM23-H1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NME1
  • 別名:
    AWD antibody; AWD, drosophila, homolog of antibody; GAAD antibody; Granzyme A activated DNase antibody; Granzyme A-activated DNase antibody; GZMA activated DNase antibody; Metastasis inhibition factor NM23 antibody; NB antibody; NBS antibody; NDK A antibody; NDKA antibody; NDKA_HUMAN antibody; NDP kinase A antibody; NDPK-A antibody; NDPKA antibody; NM23 antibody; NM23 long variant, included antibody; nm23-H1 antibody; NM23-M1 antibody; NM23H1B, included antibody; NME/NM23 nucleoside diphosphate kinase 1 antibody; Nme1 antibody; NME1-NME2 spliced read-through transcript, included antibody; Non-metastatic cells 1, protein (NM23A) expressed in antibody; Nonmetastatic cells 1, protein expressed in antibody; Nonmetastatic protein 23 antibody; Nonmetastatic protein 23, homolog 1 antibody; Nucleoside diphosphate kinase A antibody; Tumor metastatic process-associated protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human NM23-H1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
  • 基因功能參考文獻:
    1. NME1 enhanced ALDOC transcription, evidenced by increased expression of ALDOC pre-mRNA and activity of an ALDOC promoter-luciferase module. This is the first study to indicate that NME1 induces transcription through its direct binding to the promoter region of a target gene. PMID: 30396920
    2. NME1 rs16949649 associated with increased susceptibility to gynecological cancer and rs2302254 was linked to reduced gastric cancer risk (Meta-Analysis) PMID: 29525404
    3. Immunohistochemical expression of nm23H1 is not an effective tool to distinguish among the cases of BPH, adenocarcinoma of prostate with and without metastasis. Hence nm23H1 gene does not behave like an antimetastatic gene in prostatic lesions. PMID: 29567887
    4. The positive expression rates of KAI1 and nm23 were significantly lower in laryngeal squamous cell carcinoma than normal laryngeal mucosa. PMID: 29187211
    5. coexistence of high MACC1 and low NM23-H1 expression and tumor budding was associated with short overall survival PMID: 29700912
    6. elevated NDKA was associated with severe characteristics of adenomas (>/=3 lesions, size >/= 1 cm or villous component). Setting specificity to 85%, NDKA showed a sensitivity of 30.19% and 29.82% for advanced adenomas and advanced neoplasia, respectively. PMID: 27222072
    7. This study suggested that EGFR was an important predictive factor for the prognosis of the post-operative patients with colorectal carcinoma TNM stage I-II, and nm23 is important for predicting the prognosis of the patients with stage III-IV; it is better that EGFR and nm23 are as predictor of combination. PMID: 27888614
    8. Results demonstrate that nm23 plays a vital role in decidualization in mice and humans and that nm23 gene expression is hormonally regulated. PMID: 27604954
    9. NM23 might be an indicator of good prognosis in patients with breast cancer, although further researches need to be performed to confirm the prognostic value of NM23. [Meta-analysis; review] PMID: 28161101
    10. The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1/2 complex and thus the dynamic behavior of epithelia during lip/palate development. PMID: 28767310
    11. High NME1 expression is associated with well tumor differentiation in Digestive System Neoplasms PMID: 27518571
    12. Hepatitis C Virus E1 protein expression and HCV infection induces pro-metastatic effect on cancer cells which is simultaneous to Nm23-H1 transcriptional down-regulation and Nm23-H1 protein degradation. PMID: 28376369
    13. Meta-analysis showed that low expression of nm23-H1 is associated with poorer prognosis in patients with nasopharyngeal carcinoma, suggesting that it is a prognostic factor and potential biomarker for survival in nasopharyngeal carcinoma. PMID: 28614246
    14. Nm23-H1 nuclear localized mainly in the G2/M phase and the nuclear Nm23-H1 promoted A549 cell proliferation in vitro. PMID: 28442010
    15. Differential regulation of NM23-H1 may corroborate/abrogate EMT depending on the nature of stress, tumor microenvironment and cellular context. PMID: 28216015
    16. large-scale and well-designed studies, which use uniform antibody and criterion of NM23 positive expression, are required to further validate the role of the NM23 in predicting gastric cancer progression. PMID: 28401162
    17. Study reveals that NME1L may perform potent biological roles on the cellular behaviors through the extra N-terminal region as well as hexameric conformation. Because the N-terminal region itself has no effect on NF-kappaB signaling, the dimerization of NME1L is likely a pivotal process to confer the IKKbeta binding ability and subsequent regulation of NF-kappaB signaling on the region. PMID: 27094059
    18. A strong association between NME1 heterozygous genotype and breast cancer risk in Kashmiri population PMID: 27509166
    19. Down-regulation of Dyn1 activity enhances extracellular Nme1 in human colon tumor cell lines. PMID: 27449069
    20. nm23-H1 and MMP-2 may be as an indicator for esophageal cancer metastasis and prognosis PMID: 27592483
    21. Results confirmed that NME1L, but not NME1, is likely responsible for regulating breast cancer cell growth by inhibiting IGF1-stimulated ERK phosphorylation through N-terminal 25 amino acid-mediated interaction with KSR1. PMID: 26565392
    22. CRC patients with NM23-positive tumors had a better prognosis, and thus NM23 expression maybe used as a key prognostic indicator for CRC. PMID: 26634527
    23. NM23 expression is reduced in CRC tissues and low NM23 levels tightly correlate with higher Dukes stages, poorer differentiation grade, and positive lymph node metastases. PMID: 26825905
    24. Fibronectin is an important effector of the motility-suppressing function of NME1 in melanoma cells. PMID: 25808322
    25. Nm23 loss could be associated with a more favorable environment for the development and dissemination of breast cancer PMID: 25321081
    26. Dual functions of NME1 in suppression of cell motility and enhancement of genomic stability in melanoma PMID: 25017017
    27. Regulation of the metastasis suppressor Nm23-H1 by tumor viruses PMID: 25199839
    28. nm23-H1 protein may be an important prognostic factor in peripheral T-cell lymphoma, not otherwise specified;the nm23-H1-positive group had significantly shorter overall survival (Review). PMID: 25501107
    29. The case for extracellular Nm23-H1 as a driver of acute myeloid leukemia (AML) progression PMID: 25119778
    30. Interaction between Nm23 and the tumor suppressor VHL PMID: 24915993
    31. Using the described method for detecting histidine and aspartic acid phosphorylations and our prostate cancer progression cell system, the potential function of NM23-H1 in suppressing metastasis with a two-component regulation system is discussed PMID: 25373728
    32. The metastasis suppressor NME1 regulates expression of genes linked to metastasis and patient outcome in melanoma and breast carcinoma. PMID: 25048347
    33. NM23-H1 may participate in head and neck squamous cell carcinoma cell responses to cisplatin and be considered a potential therapeutic target. PMID: 25277180
    34. NM23H1 gene suppresses hyperplasia and metastasis of prostate cancer, thereby improving the survival rate. PMID: 24858271
    35. Overexpression of Nm23H1 did not affect tumorigenesis in nude mice assays, while overexpression of Nm23H2 enhanced tumor growth with elevated expression of the c-Myc proto-oncogene. PMID: 25748386
    36. NDPK-A was not able to bind to model membranes mimicking the inner leaflet of plasma membrane, suggesting that its in vivo membrane association is mediated by a non-lipidic partner or other partners than the studied phospholipids. PMID: 25010650
    37. Data shows that c-Abl and Arg induce NM23-H1 degradation by increasing expression and activation of cathepsin L and B, which directly cleave NM23-H1 in the lysosome. PMID: 24096484
    38. NME1L is a potent antimetastatic protein and may be a useful weapon in the fight against cancers. PMID: 24811176
    39. findings show NDPKs (NM23-H1/H2/H4) interact with and provide GTP to dynamins, allowing these motor proteins to work with high thermodynamic efficiency for membrane remodeling PMID: 24970086
    40. abnormal lower expression of NME1 in endometriotic stromal cells leads to more secretion of IL-8 and VEGF, up-regulates the level of CD62E and CD105, and leads to angiogenesis of vascular endothelial cells, which promotes development of endometriosis. PMID: 24133580
    41. Abnormally low expression of NME1 in endometrial stromal cells (ESCs) may be involved in the pathogenesis of endometriosis by up-regulating growth, adhesion and invasion of ESCs. PMID: 23856325
    42. Positive expression of Nm23 protein was found in ovarian tissue in 77.7 % cases in BRCA1 mutation carriers and in 90.9 % in the control group. PMID: 23553196
    43. NM23 suppressor protein may have a role in gastric carcinoma pathogenes PMID: 23725501
    44. In laryngeal squamous cell carcinoma patients, the disease recurrence rate correlates inversely with nuclear nm23-H1 expression. PMID: 23768014
    45. Data indicate that the activation of MAPK and PI3K pathways resulted in TGF-beta1 signaling by down-regulating Nm23-H1 expression and up-regulating the expression of TbetaRI and TbetaRII, favoring further activation of multiple signaling pathways. PMID: 23734265
    46. High NM23-H1 expression is associated with radioresistance in nasopharyngeal carcinoma. PMID: 23464856
    47. High NM23 expression is associated with sporadic colorectal cancer. PMID: 23679306
    48. Reduced nm23 immunohistochemical expression is an independent negative prognostic factor for overall survival and progression-free survival in invasive breast cancer. PMID: 23818346
    49. The crystal structure of oxidized Nm23-H1 is presented. It reveals the formation of an intramolecular disulfide bond between Cys4 and Cys145 that triggers a large conformational change that destabilizes the hexameric state. PMID: 23519676
    50. NM23 demonstrated no discriminatory value in the interpretation of lymph node nevus rests. PMID: 23694823

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
  • 蛋白家族:
    NDK family
  • 組織特異性:
    Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to t
  • 數據庫鏈接:

    HGNC: 7849

    OMIM: 156490

    KEGG: hsa:4830

    STRING: 9606.ENSP00000013034

    UniGene: Hs.463456



主站蜘蛛池模板: 夜夜爽妓女8888视频免费观看| 成人视频在线观看| 国产伦子系列沙发午睡| 久久亚洲中文字幕伊人久久大| 色婷婷我要去我去也| 在线精品亚洲一区二区小说| 亚洲欧洲国产成人综合在线观看 | 精品偷拍被偷拍在线观看| 午夜131美女爱做视频| 国产乱码一区二区三区爽爽爽| 成人毛片18女人毛片免费| 激情综合色五月丁香六月亚洲| 色又黄又爽18禁免费网站现观看| 午夜福利片手机在线播放| 国产成人一区二区无码不卡在线| 欧美人伦禁忌dvd放荡欲情 | 亚洲国产欧美在线人成app| 成人性生交大片免费看中文| 97精品一区二区视频在线观看| 国产精品进线69影院| 国产乱人伦偷精品视频免| 强奷妇系列中文字幕| 免费国精产品wnw2544| 爽爽精品dvd蜜桃成熟时电影院| 日韩中文高清在线专区| 国产亚洲tv在线观看| 亚洲精品久久久久午夜福利| 国产猛烈高潮尖叫视频免费| 日本伊人色综合网| 国产嘿嘿嘿视频在线观看| 欧美日韩一本的免费高清视频| 免费观看又污又黄的网站| 日本最大色倩网站www| 99久久国语露脸精品国产| 伊人无码精品久久一区二区| 国产精品∧v在线观看| 欧美激情肉欲高潮视频| 丰满人妻被公侵犯高清版| 九九线精品视频在线观看| 被拉到野外强要好爽黑人| 国产精品一线二线三线|