在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NLRX1 Antibody

  • 中文名稱:
    NLRX1兔多克隆抗體
  • 貨號:
    CSB-PA015878GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Caterpiller protein 11.3 antibody; CLR11.3 antibody; DLNB26 antibody; FLJ21478 antibody; MGC131937 antibody; MGC21025 antibody; NLR family member X1 antibody; NLR family, X1 antibody; Nlrx1 antibody; NLRX1_HUMAN antibody; NOD-like receptor X1 antibody; NOD26 antibody; NOD5 antibody; NOD9 antibody; Nucleotide-binding oligomerization domain protein 26 antibody; Nucleotide-binding oligomerization domain protein 5 antibody; Nucleotide-binding oligomerization domain protein 9 antibody; nucleotide-binding oligomerization domain, leucine rich repeat containing X1 antibody; Protein Caterpiller 11.3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NLRX1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.
  • 基因功能參考文獻:
    1. Data show that NLRX1 specifically interacts with FASTKD5 and colocalizes with mitochondrial RNA granules. Further results suggest an important role of NLRX1 in regulating the post-transcriptional processing of mitochondrial RNA, which may have an important implication in bioenergetic adaptation during metabolic stress, oncogenic transformation and innate immunity. PMID: 29932989
    2. genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (TRAF6 = TNF receptor associated factor-6) PMID: 29046236
    3. Data show that NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma. PMID: 27105514
    4. NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3. NLRX1 suppressed MAVS-mediated activation of IRF3, it conversely facilitated virus-induced increases in IRF1 expression and thereby enhanced control of viral infection. PMID: 28967880
    5. downregulated in brain injury following aneurysm PMID: 28993512
    6. The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission. PMID: 28459883
    7. we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. PMID: 26876213
    8. findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis PMID: 27393910
    9. NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review) PMID: 26763980
    10. NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha induced cell death and metabolism. PMID: 25639646
    11. These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS/RHL activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses. PMID: 25938787
    12. Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation. PMID: 24429360
    13. NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. PMID: 23321557
    14. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
    15. Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. PMID: 22718770
    16. NLRX1 attenuated IFN-I production & promoted autophagy during viral infection cells. NLRX1 interacts with TUFM. PMID: 22749352
    17. NLRX1 interacts directly with RNA and suggestts a role for NLRX1 in recognition of intracellular viral RNA in antiviral immunity. PMID: 22386589
    18. the presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production PMID: 20959452
    19. function of NOD-like receptors in the antiviral response [REVIEW] PMID: 18466630
    20. identification of NLRX1 as a check against mitochondrial antiviral responses--an intersection of three ancient cellular processes: NLR signalling, intracellular virus detection and the use of mitochondria as a platform for anti-pathogen signalling PMID: 18200010
    21. These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses. PMID: 18219313
    22. sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity PMID: 18397740
    23. NLRX1 has a functional leader sequence and fully translocates to the mitochondrial matrix. PMID: 19692591

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane.
  • 蛋白家族:
    NLRP family
  • 組織特異性:
    Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).
  • 數據庫鏈接:

    HGNC: 29890

    OMIM: 611947

    KEGG: hsa:79671

    STRING: 9606.ENSP00000292199

    UniGene: Hs.524082



主站蜘蛛池模板: av片亚洲国产男人的天堂| 熟妇熟女乱妇乱女网站| av一区二区三区人妻少妇| 无码精品人妻一区二区三区98 | 国产精品成人99久久久久| 国产av一二三无码影片| 曰本av中文字幕一区二区| 亚洲已满18点击进入在线看片| 国产精品爆乳奶水无码视频免费| 日韩精品亚洲人旧成在线| 特黄三级又爽又粗又大| 五月婷婷开心中文字幕| 丁香婷婷激情综合俺也去| 在线观看高h无码黄动漫| 欧美3p两根一起进高清视频| 国产男女猛烈无遮挡a片漫画| 变态 另类 欧美 大码 日韩| 婷婷四虎东京热无码群交双飞视频| 日本二区三区欧美亚洲国| 国产成人一区二区三区影院动漫| 欧美又大又粗午夜剧场免费| 日本丰满护士爆乳xxxx| 亚洲第一福利网站在线观看| 精品国产欧美一区二区| 国产亚洲高清国产拍精品| 成在人线av无码免费看网站直播| 中字幕一区二区三区乱码| 国产成人无码免费看片软件| 狠狠精品久久久无码中文字幕| 国产成人综合亚洲看片| 国产涩涩视频在线观看| 少妇高清精品毛片在线视频| 99精品日本二区留学生| 亚洲蜜桃v妇女| 国产毛多水多高潮高清| 日韩综合亚洲色在线影院| 97色精品视频在线观看| 无码人妻精品一区二区三区99不卡 | 欧美老肥熟妇多毛xxxxx| 色噜噜狠狠狠狠色综合久一| 丝袜人妻一区二区三区|