在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NLRX1 Antibody

  • 中文名稱:
    NLRX1兔多克隆抗體
  • 貨號:
    CSB-PA015878GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Caterpiller protein 11.3 antibody; CLR11.3 antibody; DLNB26 antibody; FLJ21478 antibody; MGC131937 antibody; MGC21025 antibody; NLR family member X1 antibody; NLR family, X1 antibody; Nlrx1 antibody; NLRX1_HUMAN antibody; NOD-like receptor X1 antibody; NOD26 antibody; NOD5 antibody; NOD9 antibody; Nucleotide-binding oligomerization domain protein 26 antibody; Nucleotide-binding oligomerization domain protein 5 antibody; Nucleotide-binding oligomerization domain protein 9 antibody; nucleotide-binding oligomerization domain, leucine rich repeat containing X1 antibody; Protein Caterpiller 11.3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NLRX1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.
  • 基因功能參考文獻:
    1. Data show that NLRX1 specifically interacts with FASTKD5 and colocalizes with mitochondrial RNA granules. Further results suggest an important role of NLRX1 in regulating the post-transcriptional processing of mitochondrial RNA, which may have an important implication in bioenergetic adaptation during metabolic stress, oncogenic transformation and innate immunity. PMID: 29932989
    2. genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (TRAF6 = TNF receptor associated factor-6) PMID: 29046236
    3. Data show that NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma. PMID: 27105514
    4. NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3. NLRX1 suppressed MAVS-mediated activation of IRF3, it conversely facilitated virus-induced increases in IRF1 expression and thereby enhanced control of viral infection. PMID: 28967880
    5. downregulated in brain injury following aneurysm PMID: 28993512
    6. The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission. PMID: 28459883
    7. we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. PMID: 26876213
    8. findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis PMID: 27393910
    9. NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review) PMID: 26763980
    10. NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha induced cell death and metabolism. PMID: 25639646
    11. These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS/RHL activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses. PMID: 25938787
    12. Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation. PMID: 24429360
    13. NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. PMID: 23321557
    14. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
    15. Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. PMID: 22718770
    16. NLRX1 attenuated IFN-I production & promoted autophagy during viral infection cells. NLRX1 interacts with TUFM. PMID: 22749352
    17. NLRX1 interacts directly with RNA and suggestts a role for NLRX1 in recognition of intracellular viral RNA in antiviral immunity. PMID: 22386589
    18. the presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production PMID: 20959452
    19. function of NOD-like receptors in the antiviral response [REVIEW] PMID: 18466630
    20. identification of NLRX1 as a check against mitochondrial antiviral responses--an intersection of three ancient cellular processes: NLR signalling, intracellular virus detection and the use of mitochondria as a platform for anti-pathogen signalling PMID: 18200010
    21. These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses. PMID: 18219313
    22. sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity PMID: 18397740
    23. NLRX1 has a functional leader sequence and fully translocates to the mitochondrial matrix. PMID: 19692591

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane.
  • 蛋白家族:
    NLRP family
  • 組織特異性:
    Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).
  • 數據庫鏈接:

    HGNC: 29890

    OMIM: 611947

    KEGG: hsa:79671

    STRING: 9606.ENSP00000292199

    UniGene: Hs.524082



主站蜘蛛池模板: 蜜桃视频在线观看免费视频网站www | 亚洲性无码av中文字幕| 国产在线精品视频二区| 国产成人精品日本亚洲999| 免费裸体无遮挡黄网站免费看| 国产精品久久久久久吹潮| 久久久综合九色合综国产精品 | 激情综合激情五月俺也去| 国内精品自线在拍2020不卡| 精品少妇人妻av免费久久洗澡| 欧美黑人添添高潮a片www| 国产麻豆 9l 精品三级站| 超薄丝袜足j好爽在线观看| 亚洲欧美色中文字幕在线| 国产97色在线 | 免| 亚洲综合另类小说色区| 99久在线国内在线播放免费观看| 99国产精品久久久久久久成人热| 高清一区二区三区日本久| 午夜尤物禁止18点击进入| 人妻插b视频一区二区三区| 少妇高潮灌满白浆毛片免费看| 99久久久无码国产精品古装| 奇米777狠狠色噜噜狠狠狠| 亚洲肥老太bbw中国熟女| 18禁裸体女免费观看| 色综合色狠狠天天综合网| 国产午夜av秒播在线观看| 中文字幕av无码一区二区三区| www国产亚洲精品久久网站| 久久国产偷任你爽任你| 中文字幕在线日亚洲9| 亚洲精品一区二区三区蜜臀| 一卡二卡3卡4卡视频免费播放| 在线看免费无码av天堂的| 亚洲人成无码网站久久99热国产| 婷婷久久香蕉五月综合| 高中国产开嫩苞实拍视频在线观看| 亚洲国产精品第一区二区| 中文字幕亚洲乱码熟女一区二区| 午夜成人亚洲理论片在线观看|