在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NLRP2 Antibody

  • 中文名稱:
    NLRP2兔多克隆抗體
  • 貨號:
    CSB-PA865163ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: NLRP2 antibody at 12µg/ml + A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 121, 119, 97, 118 kDa
      Observed band size: 121 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA865163ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NLRP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NLRP2
  • 別名:
    CLR19.9 antibody; FLJ20510 antibody; Leucine rich repeat and PYD containing protein 2 antibody; LRR and PYD domains-containing protein 2 antibody; NACHT antibody; NACHT domain antibody; NACHT leucine rich repeat and PYD containing 2 antibody; NACHT LRR and PYD domains containing protein 2 antibody; NALP2 antibody; NALP2_HUMAN antibody; NBS1 antibody; NLR family pyrin domain containing 2 antibody; NLRP2 antibody; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody; Nucleotide-binding site protein 1 antibody; PAN1 antibody; PYPAF2 antibody; PYRIN containing APAF1 like protein2 antibody; PYRIN domain and NACHT domain-containing protein 1 antibody; PYRIN-containing APAF1-like protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human NACHT, LRR and PYD domains-containing protein 2 protein (1-220AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • 基因功能參考文獻:
    1. During transition from the pluripotent stage towards the neural developmental stage, NLRP2 is differentially expressed in bipolar patient derived cells compared to control derived cells. PMID: 28117838
    2. genetic polymorphism is associated with chronic pancreatitis PMID: 26253076
    3. No disease-causing mutations were identified in NLRP2, NLRP7 and KHDC3L in cohorts of unexplained infertility and recurrent pregnancy loss. PMID: 25376457
    4. This study indicates that polymorphisms in SPARC and NLRP2 are related to rheumatoid arthritis susceptibility in a Chinese Han population. PMID: 24754275
    5. Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB RelA/p65 activity and thus represents the newest member of the POP family, pyrin-only protein 4 (POP4; NLRP4). PMID: 24871464
    6. The results of this study suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response PMID: 23625868
    7. There is a significant association of a tag single-nucleotide polymorphism (SNP) of NLRP7 (rs26949) with idiopathic recurrent miscarriage PMID: 23360675
    8. single nucleotide polymorphisms in NALP2 gene is associated with arsenic induced skin lesions, peripheral neuropathy, eye problem and respiratory diseases. PMID: 23644288
    9. Observations suggest that although NLRP7 and C6orf221 mutations are related to diploid biparental FRHMs, neither of these genes, nor NLRP2, are related to diploid HMs with biparental contributions to the molar genome. PMID: 22909446
    10. POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix PMID: 21976665
    11. Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy PMID: 19900269
    12. functions as a modulator of the activation of NF-kappaB and pro-caspase-1 in macrophages PMID: 15456791
    13. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483
    14. These findings provide molecular insight into the expression of NLRP2 by NF-kappaB. PMID: 18056399
    15. NLRP2 was preferentially expressed from the maternal allele PMID: 18369178
    16. Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation. PMID: 18772453
    17. These data show that TLR2 and NALP2 mediate the induction of human beta-defensins by F. nucleatum in gingival epithelial cells PMID: 19103770
    18. NLRP2 has a previously unrecognised role in establishing or maintaining genomic imprinting in humans. PMID: 19300480
    19. Roles of the pyrin protein which seems to have various roles in regulation of innate immunity, inflammation, and apoptosis. PMID: 19534089

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    NLRP family
  • 組織特異性:
    Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as brain, kidney, liver and spinal cord.
  • 數據庫鏈接:

    HGNC: 22948

    OMIM: 609364

    KEGG: hsa:55655

    STRING: 9606.ENSP00000409370

    UniGene: Hs.369279



主站蜘蛛池模板: 天堂在线www中文| 国产成人无码专区| 国产成人免费97在线观看| 日本欧美一区二区三区在线播放 | 男女同房做爰爽免费| 国产最新精品自产在线观看| 动漫无遮挡h纯肉亚洲资源大片| 成人免费区一区二区三区| 人妻换人妻仑乱| 永久久久免费人妻精品| 好爽好舒服要高潮了视频| 97碰碰碰人妻无码视频| 欧美激情综合色综合啪啪五月| 久久婷婷综合缴情亚洲狠狠_| 成年美女黄网站18禁免费| 男男啪啪激烈高潮cc漫画免费| 色综合色欲色综合色综合色综合r| 777yyy亚洲精品久久久| 久久精品水蜜桃av综合天堂| 中文字幕无线码一区2020青青| 四虎国产精亚洲一区久久特色 | 天天做天天爱夜夜爽毛片| 亚洲成av人影院无码不卡| 欧美丰满少妇xxxxx| 午夜精品久久久内射近拍高清 | 亚洲日本va在线视频观看| 大肉大捧一进一出好爽视频mba| 亚洲午夜福利av一区二区无码| 国产在线高清理伦片a| 又色又爽又黄又无遮挡的网站 | 国产aⅴ夜夜欢一区二区三区| 使劲快高潮了国语对白在线| 麻豆精品一卡二卡三卡| 亚洲日本乱码中文在线电影| 又大又粗弄得我出好多水| 乱人伦xxxx国语对白| 国产成人av乱码免费观看| 国产乱xxⅹxx国语对白| 日韩av高清无码| 亚洲国产成人精品无码区花野真一 | 日本道免费精品一区二区|