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NKIRAS2 Antibody

  • 中文名稱:
    NKIRAS2兔多克隆抗體
  • 貨號:
    CSB-PA015834GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NKIRAS2
  • 別名:
    DKFZP434N1526 antibody; I kappa B interacting Ras like protein 2 antibody; I-kappa-B-interacting Ras-like protein 2 antibody; Kappa B Ras protein 2 antibody; Kappa B-Ras protein 2 antibody; KappaB Ras2 antibody; KappaB-Ras2 antibody; KBRAS 2 antibody; KBRAS2 antibody; KBRS2_HUMAN antibody; MGC74742 antibody; NF kappa B inhibitor interacting Ras like protein 2 antibody; NF-kappa-B inhibitor-interacting Ras-like protein 2 antibody; NFKB inhibitor interacting Ras like 2 antibody; NFKB inhibitor interacting Ras like protein 2 antibody; NKIRAS 2 antibody; NKIRAS2 antibody
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NKIRAS2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 基因功能參考文獻:
    1. GBM cells overexpressing TNFAIP3 and NKIRAS2 were refractory to miR-125b-induced apoptosis resistance as well as TMZ resistance, indicating that both genes are relevant targets of miR-125b. PMID: 24901050
    2. KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. PMID: 20639196
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Small GTPase superfamily, Ras family, KappaB-Ras subfamily
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 17898

    OMIM: 604497

    KEGG: hsa:28511

    STRING: 9606.ENSP00000303580

    UniGene: Hs.632252



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