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NID2 Antibody

  • 中文名稱:
    NID2兔多克隆抗體
  • 貨號:
    CSB-PA015803GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NID2
  • 別名:
    NID 2 antibody; NID-2 antibody; Nid2 antibody; NID2_HUMAN antibody; Nidogen-2 antibody; Nidogen2 antibody; Osteonidogen antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NID2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
  • 基因功能參考文獻:
    1. High NID2 methylation is associated with non-small cell lung cancer. PMID: 29970687
    2. the serum NID2 levels show significant elevation in the ESCC patients and those with relatively high serum NID2 levels ( 32.6 mu mu g/L) are significantly associated with poor survival outcome compared with those with very low serum NID2 levels (< < 20.0 mu mu g/L). PMID: 29278876
    3. Addition of a TWIST1/NID2-based DNA methylation assay adds diagnostic value to urine cytology and the model is sensitive to the classification of equivocal cytology. PMID: 28106542
    4. Promoter methylation of NID2 was significantly higher in nasopharyngeal carcinoma and esophageal squamous cell carcinoma cells. NID2 suppresses the EGFR/Akt and integrin/FAK/PLCgamma metastasis-related pathways. PMID: 27793011
    5. Knockdown of nidogen-2 reduced SOX9 expression, whereas it up-regulated RUNX2 expression PMID: 26683663
    6. The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. PMID: 23681936
    7. combined methylation analysis of Twist homolog 1 and nidogen-2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine. PMID: 23682613
    8. Decreased nidogen-2 expression is associated with hepatocellular carcinoma PMID: 21815147
    9. NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma. PMID: 21558411
    10. Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125. PMID: 19883638
    11. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2 PMID: 11733994
    12. found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development PMID: 12005023
    13. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
    14. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
    15. CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines. PMID: 17328794

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  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 組織特異性:
    Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 13389

    OMIM: 605399

    KEGG: hsa:22795

    STRING: 9606.ENSP00000216286

    UniGene: Hs.369840



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