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  4. NFAM1 Antibody, FITC conjugated

NFAM1 Antibody, FITC conjugated

  • 中文名稱：
    NFAM1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA850874LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NFAM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NFAM1
  • 別名：
    NFAM1 antibody; CNAIPNFAT activation molecule 1 antibody; Calcineurin/NFAT-activating ITAM-containing protein antibody; NFAT-activating protein with ITAM motif 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human NFAT activation molecule 1 protein (186-270AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
  • 基因功能參考文獻：
    1. CNAIP is a ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway and the downstream cytokine gene promoters PMID: 12615919
    2. Our results demonstrate NFAT expression and activation in native human vessels and point out A-285222 as a powerful pharmacological blocker of NFAT signaling in the vasculature. PMID: 17079331
    3. NFAT plays a role in SV40 infection via transcriptional control of Simian Virus 40. PMID: 18031784
    4. Our findings define a pathway involving CD28 binding to Grb-2 and its co-operativity with Vav1 in the regulation of T-cell co-stimulation. PMID: 18295596
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.
  • 數據庫鏈接：

    HGNC: 29872

    OMIM: 608740

    KEGG: hsa:150372

    STRING: 9606.ENSP00000333680

    UniGene: Hs.436677



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