在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NEU2 Antibody

  • 中文名稱:
    NEU2兔多克隆抗體
  • 貨號:
    CSB-PA896716ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA896716ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NEU2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NEU2
  • 別名:
    Cytosolic sialidase antibody; MGC129579 antibody; N acetyl alpha neuraminidase 2 antibody; N-acetyl-alpha-neuraminidase 2 antibody; Neu2 antibody; NEUR2_HUMAN antibody; Neuraminidase 2 antibody; OTTHUMP00000164374 antibody; SIAL2 antibody; Sialidase 2 antibody; Sialidase-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sialidase-2 protein (171-380AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues.
  • 基因功能參考文獻:
    1. Synchrotron radiation reflectometry was used to access the transverse structure of model membranes under the action of the human sialidase NEU2, down to the Angstrom length scale PMID: 28087363
    2. cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein PMID: 26193330
    3. Circular dichroism (CD) spectra at variable temperatures have been recorded for human cytosolic sialidase NEU2 in buffered water solutions and in the presence of divalent cations. PMID: 25033330
    4. Q136K is a novel mutation in an expressed NEU2 protein that was discovered during crystallographic analysis. PMID: 23908028
    5. the present study demonstrated NEU2 expression to be detectable but very low in many human tissues and cells, and suggested possible functional roles in PC-3 prostate cancer cells. PMID: 23068092
    6. NEU2 appears to be activated when lysine 45 and glutamine 112 are mutated to alanine. PMID: 22228546
    7. HsNEU2 differentially recognizes the type of sialosyl linkage, the aglycone part of the substrate, and the supramolecular organization (monomer/micelle/vesicle) of gangliosides PMID: 14613940
    8. the first high resolution x-ray structures of sialidase, human Neu2 PMID: 15501818
    9. propose that this Asian-enriched sialidase variation caused by the SNP, likely in homozygous form, may be associated with certain severe adverse reactions to oseltamivir PMID: 17426694
    10. Neu2 loss of expression might exacerbate the defective myogenic differentiation of rhabdomyosarcoma cells. PMID: 19524683

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    Glycosyl hydrolase 33 family
  • 組織特異性:
    Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.
  • 數據庫鏈接:

    HGNC: 7759

    OMIM: 605528

    KEGG: hsa:4759

    STRING: 9606.ENSP00000233840

    UniGene: Hs.532681



主站蜘蛛池模板: 久久精品国产999久久久| 久久人人爽人人爽人人片av麻烦| 久久精品国产曰本波多野结衣| 人妻天天爽夜夜爽精品视频| 久久国产精品老女人 | 国产熟人av一二三区| 中文字幕无码人妻aaa片| 国产激情久久久久影院小草| 亚洲漂亮少妇毛茸茸| 特级毛片a片久久久久久| 成人免费xxxxx在线观看| 青草青草久热国产精品| 狠狠色色综合站| 久久午夜伦鲁片免费无码| 成人欧美一区二区三区1314| 无码吃奶揉捏奶头高潮视频| 国产在线高清视频无码| 亚洲国产精品一区二区美利坚| 女人高潮流白浆视频| 人人狠狠综合久久88成人| 精品露脸国产偷人在视频| 国产色爱av资源综合区| 国产成人精品高清在线观看99 | 成人aa免费视频在线播放| 亚洲youwu永久无码精品| 国产曰批免费视频播放免费| 99久久精品无码一区二区三区| 亚洲成h人av无码动漫无遮挡| 免费人成激情视频在线观看| 精品无码av一区二区三区不卡| 全黄h全肉边做边吃奶视频| 人妻系列无码专区av在线 | 色妺妺免费影院| 精选国产av精选一区二区三区| 无码人妻熟妇av又粗又大| 亚洲国产精品日韩av不卡在线| 国产福利一区二区麻豆| 狠狠色狠狠色综合| 无码人妻丰满熟妇区毛片18| 老汉老妇姓交视频| 亚瑟国产精品久久|