在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NEU2 Antibody

  • 中文名稱:
    NEU2兔多克隆抗體
  • 貨號:
    CSB-PA896716ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA896716ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NEU2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NEU2
  • 別名:
    Cytosolic sialidase antibody; MGC129579 antibody; N acetyl alpha neuraminidase 2 antibody; N-acetyl-alpha-neuraminidase 2 antibody; Neu2 antibody; NEUR2_HUMAN antibody; Neuraminidase 2 antibody; OTTHUMP00000164374 antibody; SIAL2 antibody; Sialidase 2 antibody; Sialidase-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sialidase-2 protein (171-380AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues.
  • 基因功能參考文獻:
    1. Synchrotron radiation reflectometry was used to access the transverse structure of model membranes under the action of the human sialidase NEU2, down to the Angstrom length scale PMID: 28087363
    2. cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein PMID: 26193330
    3. Circular dichroism (CD) spectra at variable temperatures have been recorded for human cytosolic sialidase NEU2 in buffered water solutions and in the presence of divalent cations. PMID: 25033330
    4. Q136K is a novel mutation in an expressed NEU2 protein that was discovered during crystallographic analysis. PMID: 23908028
    5. the present study demonstrated NEU2 expression to be detectable but very low in many human tissues and cells, and suggested possible functional roles in PC-3 prostate cancer cells. PMID: 23068092
    6. NEU2 appears to be activated when lysine 45 and glutamine 112 are mutated to alanine. PMID: 22228546
    7. HsNEU2 differentially recognizes the type of sialosyl linkage, the aglycone part of the substrate, and the supramolecular organization (monomer/micelle/vesicle) of gangliosides PMID: 14613940
    8. the first high resolution x-ray structures of sialidase, human Neu2 PMID: 15501818
    9. propose that this Asian-enriched sialidase variation caused by the SNP, likely in homozygous form, may be associated with certain severe adverse reactions to oseltamivir PMID: 17426694
    10. Neu2 loss of expression might exacerbate the defective myogenic differentiation of rhabdomyosarcoma cells. PMID: 19524683

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    Glycosyl hydrolase 33 family
  • 組織特異性:
    Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.
  • 數據庫鏈接:

    HGNC: 7759

    OMIM: 605528

    KEGG: hsa:4759

    STRING: 9606.ENSP00000233840

    UniGene: Hs.532681



主站蜘蛛池模板: 中日精品无码一本二本三本 | 性色av无码一区二区三区人妻| 成熟丰满熟妇高潮xxxxx| 亚洲成a人片在线观看高清| 亚洲综合无码中文字幕第2页| 亚洲精品无码久久久影院相关影片 | 亚洲精品久久中文字幕| 国产高清视频色拍| 久久国产精品_国产精品| 日本一区二区三区免费高清| 国产麻豆成人传媒免费观看| 无人区码一码二码w358cc| 亚洲人成人伊人成综合网无码| 国产97人妻人人做人碰人人爽| 一本加勒比hezyo无码专区| 国产午夜片无码区在线播放| 天堂中文最新版在线中文| 亚洲国产成人av片在线播放| 午夜私人成年影院在线观看| 欧美黑人激情性久久| 国产丝袜美女一区二区三区| 国产欧美日韩专区发布| 久热这里只有精品99| 香港三级日本三级韩级人妇| 国产日韩在线时看高清视频 | 麻豆精品国产熟妇aⅴ一区| 无码人妻精品一区二区三18禁 | 国产精品无码不卡一区二区三区| 无人区码一码二码w358cc| 国产免费无遮挡吸乳视频在线观看 | 日产a一a区二区www| 亚洲 日本 欧美 中文幕| 久久综合五月丁香六月丁香| 亚洲视频日本有码中文| 国产未成女一区二区| www婷婷av久久久影片| 老太婆性杂交欧美肥老太| 国产av高清无亚洲| 国产最新av在线播放不卡| 人妻少妇精品无码专区app| 日本55丰满熟妇厨房伦|