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  4. NELFCD Antibody

NELFCD Antibody

  • 中文名稱：
    NELFCD兔多克隆抗體
  • 貨號：
    CSB-PA815573ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: NELFCD antibody at 8μg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 67, 23, 66 kDa
      Observed band size: 67 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA815573ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NELFCD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    HSPC130 antibody; Negative elongation factor C/D antibody; NELF C antibody; NELF D antibody; NELF-C/D antibody; NELFC antibody; NELFD antibody; NELFD_HUMAN antibody; TH1 antibody; TH1-like protein antibody; TH1L antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Negative elongation factor C/D protein (346-590AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
  • 基因功能參考文獻：
    1. Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. PMID: 22238675
    2. TH1 might play an important role in regulation of proliferation and invasion in human breast cancer. PMID: 20735431
    3. These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes. PMID: 20069563
    4. diverse transcriptional consequence of NELF-mediated RNAPII pausing in the human genome PMID: 20028984
    5. In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. PMID: 11952167
    6. Trihydrophobin 1 negatively regulates A-Raf kinase PMID: 14684750
    7. A study was done of ubiquitin-dependent proeolysis of TH1L protein by E6-AP. PMID: 17131388
    8. Maternal serum Th1 cytokines concentrations increase in preterm and term delivery. PMID: 17621989
    9. TH1 interacts with PAK1 and specifically restricts the activation of MAPK modules through the upstream region of the MAPK pathway, thereby influencing cell migration. PMID: 19136554

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    NELF-D family
  • 組織特異性：
    Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 15934

    OMIM: 605297

    KEGG: hsa:51497

    STRING: 9606.ENSP00000342300

    UniGene: Hs.517148



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