在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NEK8 Antibody

NEK8 Antibody

  • 中文名稱：
    NEK8兔多克隆抗體
  • 貨號：
    CSB-PA200941
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA200941(NEK8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA200941(NEK8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NEK8
  • 別名：
    JCK antibody; NEK 8 antibody; NEK12A antibody; NEK8 antibody; NEK8_HUMAN antibody; Nephrocystin 9 antibody; Never in mitosis A-related kinase 8 antibody; NIMA (never in mitosis gene a) related kinase 8 antibody; NIMA related kinase 8 antibody; NIMA-family kinase NEK8 antibody; NIMA-related kinase 12a antibody; Nima-related protein kinase 12a antibody; NimA-related protein kinase 8 antibody; NPHP9 antibody; Serine/threonine-protein kinase Nek8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human NEK8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
  • 基因功能參考文獻：
    1. NEK8 plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51. PMID: 27892797
    2. The mutations: c.2069_2070insC variant (p.Ter693LeufsTer86), and a c.1043C>T variant (p.Thr348Met) in RCC1 domain of NEK8 in two brothers with cardiac, renal, and hepatic anomalies PMID: 26697755
    3. our study demonstrates that NEK8 human mutations cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway PMID: 26967905
    4. NEK8 may be a new target gene of HIFs; pVHL can down-regulate NEK8 via HIFs to maintain the primary cilia structure in human renal cancer cells PMID: 25451921
    5. NEK8 is essential for organ development and that the complete loss of NEK8 perturbs multiple signalling pathways resulting in a severe early embryonic phenotype. PMID: 23418306
    6. Mutation in NEK8 is associated with renal ciliopathies PMID: 23973373
    7. ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8, INVS and NPHP3. PMID: 23793029
    8. NPHP9 promotes signalling through the transcriptional co-activator TAZ. PMID: 23026745
    9. study finds that induction of ciliogenesis upon cell cycle exit is accompanied by both activation and proteasomal degradation of Nek8, and that activation is dependent upon phosphorylation within the catalytic domain PMID: 22106379
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 21068128
    11. Data demonstrate for the first time that Nek8 is a novel tumor associated gene, and shares considerable sequence homology with the Nek family of protein kinases and may be involved in G(2)/M progression. PMID: 15019993
    12. mutations cause nephronophthisis; mutant forms show defects in ciliary localization PMID: 18199800
    13. characterization of the proteome in mice that have a double point mutation in the related gene. PMID: 15872312

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Nephronophthisis 9 (NPHP9); Renal-hepatic-pancreatic dysplasia 2 (RHPD2)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性：
    Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.
  • 數據庫鏈接：

    HGNC: 13387

    OMIM: 609799

    KEGG: hsa:284086

    STRING: 9606.ENSP00000268766

    UniGene: Hs.448468



主站蜘蛛池模板： 国产精品免费看久久久无码| 亚洲精品乱码久久久久久金桔影视| 乱女伦露脸对白在线播放| 女人被狂躁c到高潮视频| 醉酒后少妇被疯狂内射视频| 国产精品欧美福利久久| 国产精品国产三级国产an| 亚洲中文字幕a∨在线| av人摸人人人澡人人超碰下载| 国产亚洲精品久久久久婷婷瑜伽| 韩国精品福利一区二区三区| 中国性少妇内射xxxx狠干| 极品国产主播粉嫩在线| 欧美va久久久噜噜噜久久| 老熟女重囗味hdxx70星空| 成人性生交大片免费看r链接| 与子敌伦刺激对白播放的优点| 婷婷五月深爱综合开心网| 永久中文字幕免费视频网站| 中文无码日韩欧| 久久99精品久久久久久| 综合三区后入内射国产馆| 亚洲精品乱码一区二区三区| 亚洲午夜福利精品无码不卡| 国产成人久久精品二区三区| 国产精品久久久久久妇女| 亚洲 欧美 另类图片| 无码制服丝袜人妻在线视频精品 | 国产成人高清精品免费| 欧美40老熟妇色xxxxx| 99久热在线精品996热是什么| 中文字幕在线观看亚洲视频| 国产一区二区三区免费高清在线播放 | 欧美一区二区三区啪啪| 在线人人车操人人看视频| 亚洲女人色综合小说| 无码av永久免费专区麻豆| 最新精品香蕉在线| 亚洲精品55夜色66夜色| 免费视频好湿好紧好大好爽| 少妇无码太爽了不卡视频在线看|