在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NEK7 Antibody, FITC conjugated

  • 中文名稱:
    NEK7兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA840576LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NEK7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    EC 2.7.11.1 antibody; NEK7 antibody; NEK7_HUMAN antibody; Never in mitosis A-related kinase 7 antibody; Never in mitosis gene a-related kinase 7 antibody; NIMA (never in mitosis gene a) related kinase 7 antibody; NIMA (never in mitosis gene a)-related expressed kinase 7 antibody; NimA related protein kinase 7 antibody; NIMA-related kinase 7 antibody; NimA-related protein kinase 7 antibody; Serine/threonine-protein kinase Nek7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase Nek7 protein (1-302AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression.
  • 基因功能參考文獻:
    1. Results demonstrate that NEK7 is involved in the timely regulation of G1 progression, S-phase entry, and procentriole formation. PMID: 28539406
    2. TRF1 phosphorylation by Nek7 favors the binding of shelterin protein TIN2 and disfavors E3 ligase Fbx4 interaction, thus preventing TRF1 ubiquitination and proteasome degradation to maintain telomere integrity. PMID: 28216227
    3. Study highlights for the first time the possible role of Nek7 in HCC progression. Nek7 would be a useful biomarker that early predicts HCC patients at higher risk of poor prognosis. PMID: 26921196
    4. NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. PMID: 26642356
    5. Results show that NEK7 was directly regulated by WHSC1 through H3K36me2 and its knockdown significantly reduced cell-cycle progression, indicating that NEK7 is a key player in the molecular pathway regulated by WHSC1. PMID: 25280969
    6. RGS2 or Nek7 depletion or even overexpression of wild-type or kinase-dead Nek7, reduced gamma-tubulin from the mitotic spindle poles. PMID: 25664600
    7. Nek7 increased Ser/Thr phosphorylation of Anks3 primarily within ankyrin domain.Interaction with Anks3 led to cytoplasmic retention and nuclear exclusion of Nek7. PMID: 26188091
    8. Nek7, was significantly associated with certain clinicopathologic indices in gallbladder carcinoma PMID: 23359173
    9. Studies indicate that autophosphorylation of Nek7 and Plk4 occurred through an intermolecular mechanism, the kinases Aurora-A and Chk2 followed an intramolecular mechanism. PMID: 23821772
    10. Precise MT dynamic instability is critical for accurate shaping of the mitotic spindle and for cilium formation, and higher MT dynamicity is associated with tumorigenicity PMID: 23313050
    11. NEK7 is essential for PCM accumulation in a cell cycle stage-specific manner. PMID: 22100915
    12. Activated by Nercc1/NEK9; part of the mitotic casscade. PMID: 12840024
    13. a role for Nek7 in regulating proper spindle assembly and mitotic progression. PMID: 17101132
    14. In consistent to the proposal, we observed a decrease in the centrosomal gamma-tubulin levels and reduction of the microtubule re-growth activity in the NEK7-suppressed cells. PMID: 17586473
    15. both Nek6 and Nek7 are activated in mitosis and that interfering with their activity by either depletion or expression of reduced-activity mutants leads to mitotic arrest and apoptosis PMID: 19414596

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性:
    Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
  • 數據庫鏈接:

    HGNC: 13386

    OMIM: 606848

    KEGG: hsa:140609

    STRING: 9606.ENSP00000356355

    UniGene: Hs.24119



主站蜘蛛池模板: 无套内射极品少妇chinese| 精品人妻无码一区二区三区| 欧美性开放情侣网站| 亚洲精品久久久一二三区 | 久久国产精品日本波多野结衣| 日产精品卡2卡三卡乱码网址| 亚洲女人被黑人巨大进入| 亚洲精品亚洲人成人网| 18禁亚洲深夜福利人口| 女人摸下面自熨视频在线播放 | 无码制服丝袜人妻在线视频精品| 无码三级在线看中文字幕完整版| 国产成年无码久久久久下载| 中国浓毛少妇毛茸茸| 久久天天躁夜夜躁狠狠i女人| 欧洲精品一卡2卡三卡4卡影视| 国产新婚夫妇叫床声不断| 国产高清在线精品一区| 午夜片神马影院福利| 新版天堂资源中文www连接| 18禁止观看强奷免费国产大片 | 精品无人码麻豆乱码1区2区| 美女张开腿让男人桶爽| 日韩新无码精品毛片| 国产成人人综合亚洲欧美丁香花| 玩两个丰满老熟女| 成人影片麻豆国产影片免费观看| 永久免费观看的毛片手机视频| 最新国产成人无码久久| 国产又色又爽又黄的免费| 国产精品久久国产三级国| 两性色午夜视频免费播放| 日本一卡二卡3卡四卡网站精品 | 99久久无码一区人妻| 蜜桃av久久久一区二区三区麻豆| 亚洲精品无码aⅴ中文字幕蜜桃| 丰满人妻在公车被猛烈进入电影| 国模小黎自慰gogo人体| 久久国产avjust麻豆| 久久精品人人爽人人爽| 中文在线www天堂网|