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  4. NEK4 Antibody

NEK4 Antibody

  • 中文名稱：
    NEK4兔多克隆抗體
  • 貨號：
    CSB-PA050172
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NEK4
  • 別名：
    NEK4 antibody; STK2 antibody; Serine/threonine-protein kinase Nek4 antibody; EC 2.7.11.1 antibody; Never in mitosis A-related kinase 4 antibody; NimA-related protein kinase 4 antibody; Serine/threonine-protein kinase 2 antibody; Serine/threonine-protein kinase NRK2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nek4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
  • 基因功能參考文獻：
    1. High NEK4 expression is associated with lung cancer and colorectal cancer. PMID: 27602754
    2. Nek4 as a novel regulator of replicative senescence and the response to double-stranded DNA damage. PMID: 22851694
    3. Nek4 interaction with both RPGRIP1 and the RPGRIP1L is involved in cilium assembly. PMID: 21685204
    4. Data show that after Taxol treatment, Nek4 promoted microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters. PMID: 20103636
  • 亞細胞定位：
    Cell projection, cilium. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性：
    Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.
  • 數據庫鏈接：

    HGNC: 11399

    OMIM: 601959

    KEGG: hsa:6787

    STRING: 9606.ENSP00000233027

    UniGene: Hs.631921



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