NEK3 Antibody
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中文名稱：NEK3兔多克隆抗體
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貨號：CSB-PA015701ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: NEK3 antibody at 6.04µg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58, 56 kDa
Observed band size: 58 kDa -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA015701ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015701ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NEK3 Polyclonal antibody
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Uniprot No.：
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基因名：NEK3
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別名：NEK3 antibody; Serine/threonine-protein kinase Nek3 antibody; EC 2.7.11.1 antibody; HSPK 36 antibody; Never in mitosis A-related kinase 3 antibody; NimA-related protein kinase 3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Serine/threonine-protein kinase Nek3 protein (267-506AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
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基因功能參考文獻：
- NEK3 kinase phosphorylates SNAP29 on its serine 105. NEK3-mediated phosphorylation determines membrane localization of SNAP29. Membrane-associated SNAP29 regulates Golgi and focal adhesion structures. PMID: 29454964
- The data demonstrate that NEK3 is overexpressed in gastric cancer, which promotes the malignancy of gastric cancer PMID: 29504992
- these data support a modulatory role for phosphorylation at NEK3 Thr-165 in focal adhesion maturation and/or turnover to promote breast cancer cell migration. PMID: 27489110
- EHD2 interacts with Nek3 [NIMA (never in mitosis in Aspergillus nidulans)-related kinase 3], a serine/threonine kinase. PMID: 21756249
- Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3). PMID: 12063396
- Nek3 insertion/deletion polymorphism with alterations at 13q14 is associated with cancers PMID: 17118778
- Nek3 contributes to prolactin-mediated breast cancer motility through mechanisms involving Rac1 activation and paxillin phosphorylation. PMID: 17297458
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亞細胞定位：Cytoplasm. Cell projection, axon.
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蛋白家族：Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
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組織特異性：Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.
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數據庫鏈接：
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