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  4. NDUFV2 Antibody

NDUFV2 Antibody

  • 中文名稱：
    NDUFV2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA052434
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells, HeLa cells, HepG2 cells and MCF-7 cells, using NDUFV2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NDUFV2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human NDUFV2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
  • 基因功能參考文獻(xiàn)：
    1. haplotype T-C consisting of rs12457810 and rs12964485 in the 5'-upstream region of NDUFV2 may be a protective factor for the development of MDD in Han Chinese PMID: 26544616
    2. We have identified NDUFV2 mutations in two families with Complex I deficiency, including a novel mutation. PMID: 26008862
    3. The results show mitochondrial haplotypes associated with polymorphism of this gene are associated with elite middle and sprint power endurance in Japanese athletes PMID: 20551160
    4. There is no statistical significance between NDUFV2 gene promoter variants and susceptibility to schizophrenia in Han Chinese. PMID: 21190551
    5. The mitochondrial targeting sequence of NDUFV2 is located at the N-terminus of the precursor protein. Impairment of mitochondrial localization of NDUFV2 as a mechanistic basis for early-onset hypertrophic cardiomyopathy and encephalopathy was established. PMID: 21548921
    6. Three single nucleotide polymorphisms in the NDUFV2 gene, were studies in bipolar disorder pateints and controls. PMID: 20978456
    7. Our findings suggest further studies addressing the role of NDUFV2 variation in Parkinson's disease may be warranted. PMID: 20971673
    8. mutation causes early onset hypertrophic cardiomyopathy and encephalopathy PMID: 12754703
    9. Polymorphisms of this gene may be one of the genetic risk factors for bipolar disorder. PMID: 12815743
    10. Polymorphisms in the promoter region of NDUFV2 are a genetic risk factor for bipolar disorder. The association of the haplotypes -602G> A and -3542G> A polymorphisms with bipolar disorder was seen both in Japanese case-control samples and NIMH trios. PMID: 15450783
    11. NDUFV2 individual genotypes were not associated with schizophrenia, but the haplotype consisting of the two single nucleotide polymorphisms were significantly associated with schizophrenia. PMID: 16508936
    12. genetic variants of NDUFV2 may increase risk for bipolar disorder. PMID: 18199248
    13. This study found that the expressions of NDUFV2 were up-regulated in those from patients with Japanese bipolar II disorder and the mRNA levels of this gene were down-regulated in Caucasian schizophrenia. PMID: 19135101
    14. Data show that the haplotype consisting of rs6506640 (-342G > A) and rs906807 (86C > T) on the mitochondrial gene NDUFV2 is found to be associated with bipolar disorder. PMID: 19194776

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  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    Complex I 24 kDa subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7717

    OMIM: 600532

    KEGG: hsa:4729

    STRING: 9606.ENSP00000327268

    UniGene: Hs.464572



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