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  4. NDST1 Antibody

NDST1 Antibody

  • 中文名稱：
    NDST1兔多克隆抗體
  • 貨號：
    CSB-PA015614GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NDST1
  • 別名：
    NDST1 antibody; HSST antibody; HSST1 antibody; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 antibody; EC 2.8.2.8 antibody; Glucosaminyl N-deacetylase/N-sulfotransferase 1 antibody; NDST-1 antibody; N-heparan sulfate sulfotransferase 1 antibody; N-HSST 1 antibody; [Heparan sulfate]-glucosamine N-sulfotransferase 1 antibody; HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 antibody; EC 3.-.-.-); Heparan sulfate N-sulfotransferase 1 antibody; EC 2.8.2.-)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human NDST1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan.
  • 基因功能參考文獻：
    1. Compound heterozygous mutations in NDST1 were identified, in the heparan sulfate N deacetylatase domain of one allele and the sulfotransferase domain of the other allele. This report expands the phenotypic spectrum of Ndst1 deficiency in humans. PMID: 28211985
    2. Among the genes enriched in this screening, the authors found that TM9SF2 is critical for N-sulfation of heparan sulfate and therefore for chikungunya virus infection because it is involved in the proper localization and stability of NDST1. PMID: 28404855
    3. Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development. PMID: 25125150
    4. demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain structures PMID: 26109066
    5. Upregulation of NDST1 is associated with chemoresistance in breast cancer. PMID: 25156775
    6. These findings establish NDST1 as a target of miR-24 and demonstrate how such NDST1 suppression in endothelial cells results in reduced responsiveness to VEGFA PMID: 23884416
    7. MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803 PMID: 21947487
    8. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. PMID: 20129923
    9. Altered expression of NDST-1 mRNA in glomerular basement membrane in puromycin aminonucleoside nephrosis. PMID: 14966466
    10. effect of targeted inactivation of the Ndst1 gene on the inflammatory response associated with allergic inflammation PMID: 19710461
    11. the expression of the NDST-1 isoform was approximately equal at all stages of mast cell maturation PMID: 19915053

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  • 相關疾病：
    Mental retardation, autosomal recessive 46 (MRT46)
  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 1 family, NDST subfamily
  • 組織特異性：
    Widely expressed. Expression is most abundant in heart, liver and pancreas.
  • 數據庫鏈接：

    HGNC: 7680

    OMIM: 600853

    KEGG: hsa:3340

    STRING: 9606.ENSP00000261797

    UniGene: Hs.222055



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