在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NDST1 Antibody

NDST1 Antibody

  • 中文名稱：
    NDST1兔多克隆抗體
  • 貨號：
    CSB-PA015614GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NDST1
  • 別名：
    NDST1 antibody; HSST antibody; HSST1 antibody; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 antibody; EC 2.8.2.8 antibody; Glucosaminyl N-deacetylase/N-sulfotransferase 1 antibody; NDST-1 antibody; N-heparan sulfate sulfotransferase 1 antibody; N-HSST 1 antibody; [Heparan sulfate]-glucosamine N-sulfotransferase 1 antibody; HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 antibody; EC 3.-.-.-); Heparan sulfate N-sulfotransferase 1 antibody; EC 2.8.2.-)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human NDST1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan.
  • 基因功能參考文獻：
    1. Compound heterozygous mutations in NDST1 were identified, in the heparan sulfate N deacetylatase domain of one allele and the sulfotransferase domain of the other allele. This report expands the phenotypic spectrum of Ndst1 deficiency in humans. PMID: 28211985
    2. Among the genes enriched in this screening, the authors found that TM9SF2 is critical for N-sulfation of heparan sulfate and therefore for chikungunya virus infection because it is involved in the proper localization and stability of NDST1. PMID: 28404855
    3. Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development. PMID: 25125150
    4. demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain structures PMID: 26109066
    5. Upregulation of NDST1 is associated with chemoresistance in breast cancer. PMID: 25156775
    6. These findings establish NDST1 as a target of miR-24 and demonstrate how such NDST1 suppression in endothelial cells results in reduced responsiveness to VEGFA PMID: 23884416
    7. MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803 PMID: 21947487
    8. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. PMID: 20129923
    9. Altered expression of NDST-1 mRNA in glomerular basement membrane in puromycin aminonucleoside nephrosis. PMID: 14966466
    10. effect of targeted inactivation of the Ndst1 gene on the inflammatory response associated with allergic inflammation PMID: 19710461
    11. the expression of the NDST-1 isoform was approximately equal at all stages of mast cell maturation PMID: 19915053

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, autosomal recessive 46 (MRT46)
  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 1 family, NDST subfamily
  • 組織特異性：
    Widely expressed. Expression is most abundant in heart, liver and pancreas.
  • 數據庫鏈接：

    HGNC: 7680

    OMIM: 600853

    KEGG: hsa:3340

    STRING: 9606.ENSP00000261797

    UniGene: Hs.222055



主站蜘蛛池模板： 精品国产一区二区三区久久久狼| 99999久久久久久亚洲| 天天天天躁天天爱天天碰| 嫩草av久久伊人妇女超级a| 丁香色欲久久久久久综合网| 久久无码潮喷a片无码高潮| 中文字幕av无码免费一区| 久久久亚洲精品一区二区三区浴池| 激情综合色综合啪啪开心| 国产α片免费观看在线人| 久久热最新网站获取| 成人无码精品一区二区三区亚洲区| 国产精品vr专区| 欧洲熟妇色xxxxx视频| 大伊香蕉精品一区二区| 狠狠躁天天躁夜夜躁婷婷| 亚洲色成人网一二三区| 天堂а√中文最新版地址在线 | 亚洲精品av一区在线观看| 成人乱码一区二区三区av| 亚洲人成在线观看| 欧美亚洲日本国产综合在线 | 久久久久亚洲精品天堂| 日本www网站色情乱码| 无套内射极品少妇chinese| 欧美高清精品一区二区| 国产亚洲精品电影网站在线观看 | 好男人社区神马在线观看www| 久久视频这里只有精品在线观看| 好爽好硬好深高潮视频456| 无码乱人伦一区二区亚洲一| 无码精品久久久久久人妻中字| 又色又爽又黄的美女裸体网站 | 少妇中文字幕乱码亚洲影视| 亚洲一区二区女搞男| 狠狠亚洲色一日本高清色| 欧美精品一区二区黄a片| 爆乳熟妇一区二区三区| 精品日本免费一区二区三区| 一个人看的免费高清www视频| 国产综合久久久久|