在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NDE1 Antibody

  • 中文名稱:
    NDE1兔多克隆抗體
  • 貨號:
    CSB-PA889142DSR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA889142DSR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) NDE1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NDE1
  • 別名:
    FLJ20101 antibody; HOM TES 87 antibody; LIS1 interacting protein NUDE1 rat homolog antibody; LIS1 interacting protein NUDE1 antibody; LIS4 antibody; NDE 1 antibody; NDE1 antibody; NDE1_HUMAN antibody; Nuclear distribution gene E homolog 1 antibody; Nuclear distribution protein nudE homolog 1 antibody; NUDE 1 antibody; NudE antibody; NudE nuclear distribution gene E homolog 1 (A. nidulans) antibody; NudE nuclear distribution gene E homolog 1 antibody; NUDE1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Nuclear distribution protein nudE homolog 1 protein (1-110AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
  • 基因功能參考文獻(xiàn):
    1. Our results show how evolutionary changes in cis as well as trans acting signals have played a fundamental role in determining NDE1 species specific splicing isoforms supporting the notion that alternative splicing plays a central role in human genome evolution, and possibly human cognitive predominance. PMID: 28266585
    2. the severity of NDE1-associated microcephaly results not from defects in mitosis, but rather the inability of neural progenitors to ever reach this stage PMID: 27553190
    3. Variation at the NDE1 locus may alter risk of mental illness, in part through modification of miR-484. NDE1 SNP rs2242549 associates with significant changes in gene expression of DISC1 network. PMID: 29142105
    4. NDE1/Lissencephaly 1 and dynactin complexes separately mediate two key components of T cell-focused secretion, namely translocation of the MTOC and lytic granules to the IS, respectively. PMID: 27534551
    5. Results indicate that the NAGK-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown (NEB) and metaphase MT-KT attachment during eukaryotic cell division. PMID: 27646688
    6. Promoter system of NDE1, which produces three distinct transcripts, each encoding for the same full-length NDE1 protein (also known as NudE), was cloned and tested in human cell lines; results highlight and clone the promoter elements required to generate systems in which the NDE1 protein is exogenously expressed under its native promoter, providing a biologically relevant model of 16p13.11 duplication in mental illness PMID: 26975893
    7. Interaction between NDE1 and high birth weight was associated with increased susceptibility to schizophrenia. PMID: 26350705
    8. study strengthens the evidence for association between rare variants within NDE1 and schizophrenia, and may shed light into the molecular mechanisms underlying this severe psychiatric disorder. PMID: 25332407
    9. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway. PMID: 26206584
    10. study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder PMID: 24785679
    11. Description of a severe microcephaly syndrome where an autosomal recessive condition combines an inherited segmental duplication mediated deletion with a mutation in the NDE1 gene within the non-deleted homolog. PMID: 23704059
    12. In three related patients with microhydranencephaly, a homozygous deletion that encompasses NDE1 exon 2 containing the initiation codon was identified. PMID: 22526350
    13. analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly. PMID: 22843697
    14. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. PMID: 21911489
    15. NDE1 mutations cause a severe microlissencephaly syndrome. Patient's NDE1 proteins are unstable, cannot bind cytoplasmic dynein, and do not localize properly to the centrosome. PMID: 21529751
    16. NDE1 deficiency causes both a severe failure of neurogenesis and a deficiency in cortical lamination PMID: 21529752
    17. The NDE1 gene is disrupted by the inv(16) in 90% of cases with CBFB-MYH11-positive acute myeloid leukemia. PMID: 20072148
    18. NDE1 and NDEL1 act upstream of LIS1 in dynein recruitment, and/or activation, on the membrane. PMID: 20048338
    19. LIS1 deficiency adversely affects the migration and differentiation of DCX- and Reelin-positive neurons. PMID: 12427674
    20. study of the properties of NudE in mitosis; comparative studies suggest that NudE is functionally related to its paralog, Nudel PMID: 12556484
    21. Nudel is seen to differentially associate with mitochondrial markers in comparison to DISC1. Disruption of the cytoskeleton results in colocalization of Nudel and mitochondrial markers--the first observation of such a direct relationship. PMID: 15797709
    22. findings indicate that Nde1 can form a protein complex with Su48 in the centrosome and plays an important role for successful mitosis PMID: 16682949
    23. Two additional loci displayed an evidence of linkage (LOD > 3) and included a locus on 16p13, proximal to the gene encoding NDE1, which has been shown to biologically interact with DISC1. PMID: 17185386
    24. required for kinetochore localization of dynein; suppression of Nde1 inhibits metaphase chromosome alignment and activates the spindle checkpoint PMID: 17600710
    25. We failed to find the association between the NDE1 gene and schizophrenia in the Japanese population. PMID: 18178387
    26. These findings reveal a novel regulatory mechanism of vimentin transport during neurite extension that may have implications in diseases featuring transport/trafficking defects and impaired regeneration. PMID: 18303022
    27. NO direct relationship between NDE1 genotype and schizophrenia. PMID: 18469341
    28. NDE1, NDEL1 and LIS1, together with their binding partner dynein, associate with DISC1, PDE4B and PDE4D within the cell, and provide evidence that this complex is present at the centrosome. PMID: 18983980

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Lissencephaly 4 (LIS4); Microhydranencephaly (MHAC)
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.
  • 蛋白家族:
    NudE family
  • 組織特異性:
    Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17619

    OMIM: 605013

    KEGG: hsa:54820

    STRING: 9606.ENSP00000345892

    UniGene: Hs.655378



主站蜘蛛池模板: 国产小呦泬泬99精品| 久在线视视频在线观看| √最新版天堂资源网在线下载 | 强行交换配乱婬bd| 性色高清xxxxx厕所偷窥| 成人午夜福利免费体验区| 中文字幕久久熟女人妻av免费| 欧美精品国产aⅴ一区二区在线| 欧洲av成本人在线观看免费| 麻豆国产成人av高清在线观看| 国产a∨精品一区二区三区不卡| 色哟哟国产精品免费观看| 白嫩无码人妻丰满熟妇啪啪区百度| 最新亚洲中文字幕在线观看| 国精产品一区一区三区mba下载| www夜片内射视频日韩精品成人| 99久久无色码中文字幕人妻蜜柚| 国产精品成人99久久久久| 亚洲爆乳无码专区| 久久精品国产一区二区三区| 亚洲乱码中文论理电影| 亚洲愉拍99热成人精品热久久| 免费观看羞羞视频网站| 国产玉足脚交极品在线播放| 欧美人与禽z0zo牲伦交| 亚洲欧洲中文日韩久久av乱码| 亚洲欧美一区二区三区在线| 久久精品国产久精国产果冻传媒| 精品乱码一区二区三四五区| 夜夜夜夜曰天天天天拍国产| 日韩无套内射视频6| av无码久久久久不卡网站下载| 国产无遮挡吃胸膜奶免费看| 亚洲 自拍 另类小说综合图区| 国产精品aⅴ在线观看| 国产精品久久久久久2021| 国产欧美综合一区二区三区| 亚洲人成网站在线无码| 中文国产成人精品久久app| 久久国产精品99国产精| 色多多成视频人在线观看|