在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NCS1 Antibody

  • 中文名稱:
    NCS1兔多克隆抗體
  • 貨號:
    CSB-PA008983GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NCS1
  • 別名:
    9430075O15Rik antibody; A730032G13Rik antibody; AI836659 antibody; DKFZp761L1223 antibody; FLUP antibody; FREQ antibody; Frequenin antibody; Frequenin homolog (Drosophila) antibody; Frequenin homolog antibody; Frequenin like protein antibody; Frequenin, Drosophila, homolog of antibody; Frequenin-like protein antibody; Frequenin-like ubiquitous protein antibody; Mfreq antibody; NCS 1 antibody; NCS-1 antibody; ncs1 antibody; NCS1_HUMAN antibody; Neuronal calcium sensor 1 antibody; Neuronal Calicum Sensor 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FREQ
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
  • 基因功能參考文獻:
    1. NCS-1, a calcium-binding protein, is associated with clinicopathologic features of aggressiveness in breast cancer cells and worse outcome in two breast cancer patient cohorts PMID: 28275088
    2. Results show that although NCS-1 Var2mRNA can be detected, protein expression was not detectable. When overexpressed in cell lines NCS-1 Var2 appears to be folded properly, yet it has a lower calcium affinity. Because most NCS-1 binding to its protein partners requires calcium binding, it is unlikely that NCS-1 Var2 would play a major regulatory role in cells. PMID: 27575489
    3. structural and dynamical response of NCS-1 protein to elevated temperature may be one of its intrinsic functional properties PMID: 27007011
    4. Lithium normalizes gamma band oscillations mediated by P/Q-type calcium channels modulated by NCS-1. PMID: 27033453
    5. Study determined the salient features of the folding free-energy landscapes of the Mg2+-bound and apo states of NCS-1 PMID: 26153708
    6. results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors PMID: 25343687
    7. single-molecule optical tweezers were used to monitor misfolding reactions of the human neuronal calcium sensor-1. PMID: 25157171
    8. A strong liason was characterized between myristoylation and cryptic EF-1 in NCS-1. PMID: 25565019
    9. The functional link in substantia nigra dopamine neurons between Cav1.3- L-type-Ca2+ channels and D2-autoreceptor activity is an adaptive signalling network controlled by NCS-1. PMID: 24934288
    10. NCS1 has evolved a remarkable complex interdomain cooperativity and a fundamentally different folding mechanism compared to structurally related proteins. PMID: 24012477
    11. data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of Cocaine Abuse in individuals of African descent. PMID: 22999924
    12. [review] Receptor interaction properties in schizophrenia are dependent upon NCS-1, a protein found to regulate the phosphorylation, trafficking, and signaling profile of the D2 dopamine receptor (D2R) in neurons. PMID: 21777187
    13. the C-terminal tail is important for regulating the conformational stability of NCS1 in Ca(2+)-activated state PMID: 22227393
    14. analysis of the interaction between the D2 dopamine receptor and neuronal calcium sensor-1 PMID: 21875085
    15. it is possible to protect cells from paclitaxel-induced degradation of NCS-1 by inhibiting calpain activity PMID: 21808066
    16. NCS-1 is a novel regulator of cardiac calcium signaling, specifically in immature and hypertrophic hearts. PMID: 21737792
    17. Impairment of the normal cycling of NCS-1 by the R102Q mutation could have subtle effects on neuronal signalling and physiology in the developing and adult brain. PMID: 20479890
    18. up-regulated in the prefrontal cortex of schizophrenic and bipolar patients PMID: 12496348
    19. Analysis with chimeric proteins between KChIP2 and NCS-1 reveals that the three regions of KChIP2 are necessary and sufficient for its effective binding to Kv4.3 protein PMID: 12928444
    20. may serve as regulator of certain isoforms of phosphatidylinositol 4-kinase PMID: 14512421
    21. key role for residues within the motif EELTRK in NCS-1 in keeping the myristoyl group exposed and allowing the protein to be constitutively membrane-associated. PMID: 14726528
    22. NCS-1 is shown to be mainly associated with azurophilic granules in human neutrophils and promyelocitic cells and, therefore could play an instrumental role in the calcium-dependent secretion of azurophilic granules PMID: 14760944
    23. These results demonstrate a novel role for NCS-1 and PI4Kbeta in regulating ERK1/2 signaling and inflammatory reactions in mast cells. PMID: 16837555
    24. NCS-1 expression was diminished in CD4+T lymphocytes, CD19+ B lymphocytes and CD14+ monocytes of bipolar disorder patients and also decreased in CD4+ T lymphocytes and CD56+ natural killer cells of schizophrenia patients PMID: 19091302
    25. occurrence of an unusual TG 3' splice site in intron 2 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus. Cell junction, synapse, postsynaptic density. Cytoplasm, perinuclear region. Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Lipid-anchor.
  • 蛋白家族:
    Recoverin family
  • 數據庫鏈接:

    HGNC: 3953

    OMIM: 603315

    KEGG: hsa:23413

    STRING: 9606.ENSP00000361475

    UniGene: Hs.642946



主站蜘蛛池模板: 亚洲国产成人久久一区| 国产高清无密码一区二区三区| 性少妇中国内射xxxx狠干| 亚洲 另类 熟女 字幕| 国产 在线 | 日韩| 欧美肥胖老太vidio在线视频 | 亚洲色欲色欲www在线丝| 少女韩国电视剧在线观看完整| 久青草无码视频在线观看| 国产福利萌白酱精品tv一区| 亚洲无日韩码精品| 中文无码精品a∨在线| 亚洲熟妇丰满多毛xxxx| 欧美激情性做爰免费视频| 日本人妻伦在线中文字幕| 亚洲欧洲国产码专区在线观看 | 国产成人无码a区在线| 久久俺也去丁香综合色| 樱花草在线社区www中国| 青青草大香焦在线综合视频| 国产农村妇女精品一二区| 永久免费看啪啪的网站| 亚洲一区爱区精品无码| 久青青视频在线观看久| 亚洲色成人网一二三区| 精品一区二区ww| 国产精品视频一区二区亚瑟| 影视av久久久噜噜噜噜噜三级| 国产精品久久一区二区三区| 伊人色综合久久天天| 在线天堂资源www在线中文 | 亚洲精品一区久久久久| 日韩夜夜高潮夜夜爽无码| 欧美顶级metart裸体全部自慰| 人妻av无码系列专区移动可看| 成人av一本不卡二卡| 国产乱子影视频上线免费观看| 久久久久久久无码高潮| 精品国产免费第一区二区三区| 狠狠色丁香久久婷婷综合蜜芽五月 | 激情综合色综合啪啪五月丁香搜索|