在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NCOA3 Antibody

  • 中文名稱:
    NCOA3兔多克隆抗體
  • 貨號:
    CSB-PA571370
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA571370(NCOA3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ACTR antibody; AIB 1 antibody; AIB-1 antibody; AIB1 antibody; Amplified in breast cancer 1 antibody; Amplified in breast cancer 1 protein antibody; bHLHe42 antibody; CAGH 16 antibody; CAGH16 antibody; CBP interacting protein antibody; CBP-interacting protein antibody; Class E basic helix-loop-helix protein 42 antibody; CTG 26 antibody; CTG26 antibody; KAT13B / AIB1 antibody; MGC141848 antibody; NCOA 3 antibody; NCoA-3 antibody; Ncoa3 antibody; NCOA3_HUMAN antibody; Nuclear receptor coactivator 3 antibody; pCIP antibody; RAC 3 antibody; RAC-3 antibody; RAC3 antibody; Receptor associated coactivator 3 antibody; Receptor-associated coactivator 3 antibody; SRC 3 antibody; SRC-3 antibody; SRC3 antibody; Steroid receptor coactivator protein 3 antibody; Thyroid hormone receptor activator molecule 1 antibody; TNRC14 antibody; TNRC16 antibody; TRAM 1 antibody; TRAM-1 antibody; TRAM1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human NCOA3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
  • 基因功能參考文獻:
    1. AKT is involved in regulating AIB1 recruitment to the PS2 promoter region in the presence of IGF-1. AIB1 overexpression in breast cancer cells increases AKT activity, as well as enhances PI3K/AKT-mediated cell cycle S phase entry. PMID: 29808803
    2. Study shows that oxidative stress plays a crucial role in controlling steroid receptor coactivator 3 expression, which influences the migration and tube formation abilities of endothelial cells through the PI3K/Akt/mTOR signaling pathways. PMID: 28826365
    3. stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose but reduced MEK/MAPK phosphorylation, reduced anchorage-independent growth, and modulated expressions of GLUT1 and Ras pathway related proteins. PMID: 29301589
    4. The Authors reveal a gender difference in the prognostic value of concomitant AIB1 and HER2 copy number gain (CNG) in glioma patients which were barely noticed before. These observations indicated that genetic alterations synergistic with essential respects of sex determination influence glioma biology and patients outcomes. PMID: 30153912
    5. NCOA3 maintained the molecular signature of chondrocytes dedifferentiating in vitro or exposed to IL-1 beta and NCOA3 lose promotes posttraumatic OA at least partially by enhancing NF-kappaB activation. PMID: 30261507
    6. Data suggest that NEAT1, SRC3, and IGF1R are highly expressed in prostate cancer cells; NEAT1 appears to interact with SRC3 and promote cell proliferation via up-regulation of SRC3/IGF1R/AKT signaling pathway. (NEAT1 = nuclear paraspeckle assembly transcript-1; SRC3 = steroid receptor coactivator protein-3; IGF1R = insulin-like growth factor 1 receptor) PMID: 29225160
    7. findings suggest that the Warburg pathway enzyme PFKFB4 acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours PMID: 29615789
    8. Findings demonstrate how SRC3 and Cx43 regulation between BMSCs and myeloma cells mediate cell growth and disease progression. PMID: 29075794
    9. RAC3 bound tightly to the ARE enhancer region of the HO-1 promoter via Nrf2 binding. PMID: 22370642
    10. Hypoxia inhibits the RAC3 gene expression leading to the autophagy process, allowing tumor cells to survive until angiogenesis occurs PMID: 22957814
    11. RAC3 is an inhibitor of senescence whose downregulation in aged individuals could be probably a tumor suppressor mechanism. PMID: 26469953
    12. The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 and EIF5A2 show promise for the noninvasive detection of bladder cancer. The model based on AIB1, EIF5A2, and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer. PMID: 27203388
    13. our study implicates that AIB1 is a molecular target of sorafenib and downregulation of AIB1 contributes to the anti-tumor effects of sorafenib PMID: 27105488
    14. our studies illustrate that SRC-3 overexpression is clinically and functionally relevant to the progression of human ESCC. PMID: 27781415
    15. Estrogen receptor recruits steroid receptor coactivator-3 primary coactivator and secondary coactivators, p300/CBP and CARM1 to regulate genetic transcription. PMID: 28844863
    16. loss of miR-17 and miR-20b enhanced breast cancer resistance to taxol by upregulating NCOA3 levels. PMID: 27831559
    17. Data (including data from studies of hydrogen-deuterium exchange coupled to mass spectrometry in presence of denaturants) suggest that, for peptide fragments of human ACTR and mouse Crebbp representing disordered interaction domains, exchange rates are changed dramatically by high concentrations of denaturants guanidinium chloride or urea. (ACTR = activator of thyroid and retinoid receptor; Crebbp = CREB binding protein) PMID: 28675294
    18. Data suggest that steroid receptor coactivators (NCOA1, NCOA2, NCOA3) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW] PMID: 28390937
    19. Here, we reported the novel finding that depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC inhibitors (SAHA and romidepsin). In contrast, overexpression of SRC-3 decreased SAHA-induced cancer cell apoptosis. Furthermore, we found that SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC inhibitors. The combination of bufalin and SAHA was particular efficient in attenuating PMID: 27425252
    20. Altered expression of AIB1 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system. PMID: 26040939
    21. The oncogenic transcription factor AIB1 has a novel role in the regulation of polyribosome recruitment and formation of the translational complex. Combinatorial therapies targeting IGF signaling and mRNA translation in AIB1 expressing breast cancers may have clinical benefit and warrants further investigation PMID: 26936396
    22. Total SRC3 is selectively found at enhancer regions. PMID: 26369632
    23. The transcriptional coactivator SRC-3. PMID: 26833126
    24. The aim of this study was to investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with Ki67 expression. PMID: 26345978
    25. NCOA3 polymorphisms might influence the risk of dyslipidemia and serum lipid levels in Chinese Han population. PMID: 26449542
    26. miR-137 has a role in targeting p160 steroid receptor coactivators SRC1, SRC2, and SRC3 and inhibits cell proliferation PMID: 26066330
    27. AIB1 promotes gastric cancer cell proliferation, survival and invasiveness through modulating major signaling pathways such as ErbB and Wnt/beta-catenin pathways. Findings suggest that AIB1 plays an important role in the pathogenesis of gastric cancer. PMID: 25970779
    28. ER-alpha, SRC-3, and p300 form an active protein complex on estrogen response element-DNA. PMID: 25728767
    29. NCOA3 is subject to a cis-acting expression quantitative trait locus in articular cartilage, which correlates with the osteoarthritis association signal and with the OA-associated allele of the SNP rs116855380, which is located 10.3 kb upstream of NCOA3. PMID: 26211391
    30. we describe a TR-FRET assay that monitors the interaction of the estrogen receptor (ER) alpha ligand binding domain (labeled with a terbium chelate via a streptavidin-biotin interaction) with a sequence of coactivator protein SRC3 PMID: 25859975
    31. NCOA3 upregulates mucin 1 and 4 via transcriptional and post-translational changes in pancreatic cancer. PMID: 25531332
    32. Data suggest that over-stimulating the steroid seceptor coactivators SRC-1, SRC-2, and SRC-3 oncogenic program can be an effective strategy to kill cancer cells. PMID: 26267537
    33. AIB1 promotes colorectal cancer progression at least in part through enhancing Notch signaling. PMID: 25263446
    34. Our study clearly demonstrated differentiation-dependant expression of SRC-1 and SRC-3 in chondrosarcoma PMID: 24875297
    35. Results indicate a combination of decreased expression of ERs, AR and SRC-3 but not SRC-1 may be involved in the tumorigenesis of gliomas, ERalpha/SRC-3 axis may play central role in the regulation these tumors. PMID: 24680642
    36. AIB1, AIB1-delta4 and ANCO1 are important determinants of endocrine and growth factor responsiveness in breast cancer. PMID: 24678732
    37. verrucarin A is a potent and selective SMI that blocks SRC-3 function through an indirect mechanism. PMID: 24743578
    38. we found that MicroRNA-195 (miR-195) could negatively regulate protein levels of SRC-3 through targeting its 3'-untranslated region (3'-UTR) in hepatocellular carcinoma (HCC) cells PMID: 24740565
    39. ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. PMID: 24585635
    40. The above results clearly demonstrated a high frequency of overexpression of SRC-3 immunoreactivities in different bone cancers, indicating its potential roles in the prognosis and treatment of these cancers. PMID: 24134957
    41. Results propose that increased expression of AIB1, through the maintenance of breast cancer-initiating cell, facilitates formation of ductal carcinoma in situ, a necessary step before development of invasive disease PMID: 23851504
    42. Bufalin as a potent small-molecule inhibitor for SRC-3 and SRC-1. PMID: 24390736
    43. overexpression of SRC-3 promoted glycolysis in bladder cancer cells through HIF1alpha to facilitate tumorigenesis, which may be an intriguing drug target for bladder cancer therapy. PMID: 24584933
    44. Up-regulation of nuclear receptor coactivator amplified in breast cancer-1 in papillary thyroid carcinoma correlates with lymph node metastasis. PMID: 23606350
    45. Our results suggest that high AIB1 is a predictive marker of good response to tamoxifen treatment in postmenopausal women and a prognostic marker of decreased recurrence-free survival in systemically untreated patients. PMID: 23670096
    46. FoxG1 can function as a pro-apoptotic factor in part through suppression of AIB1 coactivator transcription complex formation, thereby reducing the expression of the AIB1 oncogene. PMID: 23660594
    47. NCOA3 is a selective co-activator of estrogen receptor alpha-mediated transactivation of PLAC1. PMID: 24304549
    48. Up-regulation of SRC-3 is associated with bladder cancer. PMID: 23886194
    49. AIB1 exerted its effect on epithelial mesenchymal transition through its interaction with ERalpha, which could directly bind to the ERalpha-binding site on the SNAI1 promoter. PMID: 23762395
    50. study confirm AIB1 to be a negative prognostic factor in an independent cohort of lymph-node-negative premenopausal breast cancer patients PMID: 23230135

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
  • 蛋白家族:
    SRC/p160 nuclear receptor coactivator family
  • 組織特異性:
    Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
  • 數據庫鏈接:

    HGNC: 7670

    OMIM: 601937

    KEGG: hsa:8202

    STRING: 9606.ENSP00000361066

    UniGene: Hs.592142



主站蜘蛛池模板: 午夜dj高清免费观看视频| 久久国产色欲av38| 999久久久无码国产精品| 亚洲精品午夜久久久伊人| 亚洲精品成人av在线观看爽翻天| 边喂奶边中出的人妻| 无码熟妇人妻av在线电影| 国产美女精品一区二区三区 | 中文无码乱人伦中文视频在线| 亚洲久热无码av中文字幕| 久久精品中文騷妇女内射| 最新永久无码av网址亚洲| 丁香五月综合久久激情| 亚洲国产精品无码中文lv| 亚洲一区二区三区四区| 无码精品人妻一区二区三区漫画| 欧美艳星nikki激情办公室| 日本又色又爽又黄的视频免 | 无码人妻丰满熟妇啪啪7774| 国产av中文av无码av狼人| 久热中文字幕无码视频| 男女啪啪网站大全免费| 无码人妻丰满熟妇啪啪欧美| 国产高清av首播原创麻豆| 国产成人综合久久三区| 亚洲综合无码无在线观看| 日本真人边吃奶边做爽电影| 色插图午夜影院| 亚洲成熟女人毛毛耸耸多| 国内无遮挡18禁无码网站免费| 午夜性刺激在线视频免费| 成人毛片18女人毛片免费| 久久午夜福利无码1000合集| 亚洲一本大道av久在线播放| 男女做爰猛烈啪啪吃奶动| 国产精品久久久久蜜芽| 国产精品水嫩水嫩| 人成午夜大片免费视频77777| 国产精品人成在线播放新网站| 国产午夜鲁丝片av无码| 男女啪啪永久免费观看网站|