在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NCEH1 Antibody

NCEH1 Antibody

  • 中文名稱：
    NCEH1兔多克隆抗體
  • 貨號：
    CSB-PA109556
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA109556(NCEH1 Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA109556(NCEH1 Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse kidney tissue, Mouse heart tissue, Primary antibody: CSB-PA109556(NCEH1 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Arylacetamide deacetylase like 1 antibody; Arylacetamide deacetylase-like 1 antibody; NCEH antibody; Nceh1 antibody; NCEH1_HUMAN antibody; Neutral cholesterol ester hydrolase 1 antibody; Neutral cholesterol ester hydrolase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human NCEH1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:100-1:300
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
  • 基因功能參考文獻：
    1. Authors discovered that the presence of cholesterol, LDLR-mediated cholesterol endocytosis, and cholesterol efflux are all essential to NCEH-1-mediated neuroprotection. In protecting from alpha-synuclein neurotoxicity, NCEH-1 also stimulates cholesterol-derived neurosteroid formation and lowers cellular reactive oxygen species in mitochondria. PMID: 28934392
    2. Psoriasis inflammation induced microRNA targets NCEH1 in underlying subcutaneous adipose tissue. PMID: 27015452
    3. Together, the results define the kinetics of inhibition of KIAA1363 by active metabolites of agrochemicals and indicate that KIAA1363 is highly sensitive to inhibition by these compounds. PMID: 26617293
    4. Pioglitazone increases ABCA1 expression in an LXR-dependent manner and NCEH1 expression in an LXRalpha-independent manner. PMID: 25280398
    5. Inhibition of AADACL1 activity with a variety of agents blocked platelet aggregation in response to multiple agonists; blocked activation of the small GTPase RAP1 and protein kinase C (PKC). PMID: 23993462
    6. NCEH1 is expressed in human atheromatous lesions, where it plays a critical role in the hydrolysis of cholesterol ester in human macrophage foam cells, thereby contributing to the initial part of reverse cholesterol transport in human atherosclerosis. PMID: 20947831
    7. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated neutral cholesterol ester hydrolase 1 in 20 healthy individuals. PMID: 20353815
    8. KIAA1363, an uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and lysophosphatidic acid. PMID: 17052604
    9. The KIAA1363, an uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and lysophosphatidic acid. PMID: 17052608
    10. NCEH is responsible for a major part of nCEH activity in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis. PMID: 18782767

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein. Microsome.
  • 蛋白家族：
    'GDXG' lipolytic enzyme family
  • 組織特異性：
    Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
  • 數據庫鏈接：

    HGNC: 29260

    OMIM: 613234

    KEGG: hsa:57552

    STRING: 9606.ENSP00000442464

    UniGene: Hs.444099



主站蜘蛛池模板： 久久精品第九区免费观看| 欧美506070老妇乱子伦| 免费无遮挡很爽很污很黄的网站| 亚洲中文字幕日产无码2020| 亚洲成在人线在线播放无码| 日本极品少妇xxxx| 四虎国产精亚洲一区久久特色 | 国产美熟女乱又伦av果冻传媒 | av永久天堂一区| 午夜不卡av免费| 日本十八禁视频无遮挡| 18禁黄网站禁片无遮挡观看| 久久精品国产久精国产爱| 人妻一本久道久久综合久久鬼色| 国产成人精品日本亚洲77上位| 国产精品亚洲а∨天堂免下载| awww在线天堂bd资源在线| 极品少妇被猛得白浆直流草莓视频| 中文字幕乱码亚洲精品一区| 国产无套粉嫩白浆在线| 久久久久人妻一区视色| 国产成年无码久久久久下载 | 在线观看麻豆国产成人av在线播放| 日韩人妻无码精品专区综合网| 久久99精品九九九久久婷婷| 人妻熟女αⅴ一区二区三区| 午夜成人爽爽爽视频在线观看| av无码国产在线看免费网站| 亚洲日本va中文字幕久久| 亚洲中文字幕无码专区| 亚洲男人片片在线观看| 99精品国产一区二区三区不卡| 伊人色综合一区二区三区| 熟女人妻av粗壮巨龙| 国产 日韩 另类 视频一区| 无码国产精品一区二区免费模式| 精品国产精品久久一区免费式| 少妇spa推油被扣高潮| 爱情岛论坛网亚洲品质| 日韩一区二区三区无码影院| 国产毛片不卡野外视频|