在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NCBP2 Antibody

  • 中文名稱:
    NCBP2兔多克隆抗體
  • 貨號:
    CSB-PA276925
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COLO205 cells, using NCBP2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NCBP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human NCBP2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
  • 基因功能參考文獻:
    1. NCBP2 is not required for cell viability and poly(A) RNA export. PMID: 26382858
    2. A novel alternative splice variant of CBP20, termed CBP20S, has an in-frame deletion, leading to the translation of a protein lacking most of the RNA recognition motif (RRM). PMID: 21326824
    3. crystal structure at 2.1 A resolution of CBP20 and CBP80 bound to an m(7)GpppG cap analogue PMID: 12374755
    4. Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. PMID: 12434151
    5. We show that NELF interacts with the nuclear cap binding complex (CBC), a heterodimeric, multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3' end processing of histone mRNAs PMID: 17499042
    6. a new MIF4G domain-containing protein, CTIF (CBP80/20-dependent translation initiation factor) that interacts directly with CBP80 and is part of the CBP80/20-dependent translation initiation complex PMID: 19648179
    7. determined how importin-beta binds to the cap-binding complex (CBC) through its CBP20 subunit PMID: 19668212

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    RRM NCBP2 family
  • 數據庫鏈接:

    HGNC: 7659

    OMIM: 605133

    KEGG: hsa:22916

    STRING: 9606.ENSP00000326806

    UniGene: Hs.591671



主站蜘蛛池模板: 欧美xxxxx高潮喷水| 2020最新无码国产在线观看| 久久亚洲精品成人av二次元| 国产欧色美视频综合二区| 国产成人a无码短视频| 亚洲愉拍99热成人精品热久久 | 又黄又爽吃奶视频在线观看| 九九精品成人免费国产片| 无码国产玉足脚交极品播放| 亚洲日韩精品国产一区二区三区| 99国产精品永久免费视频| 亚洲一区二区观看播放| 亚洲va在线va天堂xx xx| 69风韵老熟女口爆吞精| 又大又硬又黄的免费视频| 亚洲国产成人一区二区精品区| 风韵人妻丰满熟妇老熟女| 亚洲精品国产自在久久| 色在线亚洲视频www| 人妻互换一二三区激情视频| 毛片24种姿势无遮无拦| 伊人久久大香线蕉午夜av| 97se狼狼狼狼狼亚洲网| 午夜一区一品日本| 久久人搡人人玩人妻精品首页| 国产午夜理论片不卡| 国产精品高潮呻吟av久久| 一二三四在线观看视频韩国| 少妇性饥渴无码a区免费| 国产激情综合五月久久| 午夜福利无遮挡十八禁视频| 亚洲午夜未满十八勿入| 国内精品久久久久久久97牛牛| 色老久久精品偷偷鲁| 欧美综合自拍亚洲图久青草| 国产精品玖玖玖在线| 中文字幕亚洲无线码| 高潮喷水无码av亚洲| 亚洲日韩国产中文其他| 午夜成人鲁丝片午夜精品| 亚洲久悠悠色悠在线播放|