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NCAPH Antibody

  • 中文名稱：
    NCAPH兔多克隆抗體
  • 貨號：
    CSB-PA621857DSR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA621857DSR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NCAPH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NCAPH
  • 別名：
    Barren Drosophila Homolog of 1 antibody; Barren homolog protein 1 antibody; BRRN antibody; BRRN1 antibody; CAP H antibody; CAPH antibody; Chromosome associated protein H antibody; Chromosome-associated protein H antibody; CND2_HUMAN antibody; Condensin complex subunit 2 antibody; Condensin subunit 2 antibody; Condensin-2 complex subunit H2 antibody; Condesin antibody; HCAP H antibody; hCAP-H antibody; KIAA0074 antibody; mCAP H antibody; MGC4616 antibody; Ncaph antibody; Non SMC condensin I complex subunit H antibody; Non-SMC condensin I complex subunit H antibody; XCAP H homolog antibody; XCAP-H homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Condensin complex subunit 2 protein (1-250AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
  • 基因功能參考文獻：
    1. NCAPH high expression promotes colonic cancerous cell proliferation. PMID: 28300828
    2. Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death. PMID: 21151026
    3. Our results identify a SSB-specific response of condensin I through PARP-1 and demonstrate a role for condensin in SSB. repair. PMID: 16543152
  • 亞細胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    CND2 (condensin subunit 2) family
  • 組織特異性：
    Widely expressed at low level. Expressed in proliferating cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1112

    OMIM: 602332

    KEGG: hsa:23397

    STRING: 9606.ENSP00000240423

    UniGene: Hs.308045



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