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  4. NCAPG Antibody

NCAPG Antibody

  • 中文名稱：
    NCAPG兔多克隆抗體
  • 貨號：
    CSB-PA050016
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NCAPG
  • 別名：
    CAPG antibody; CHCG antibody; Chromosome associated protein G antibody; Chromosome condensation protein G antibody; Chromosome-associated protein G antibody; CND3_HUMAN antibody; Condensin complex subunit 3 antibody; Condensin subunit CAP G antibody; Condensin subunit CAP-G antibody; HCAP G antibody; hCAP-G antibody; Melanoma antigen NY MEL 3 antibody; Melanoma antigen NY-MEL-3 antibody; NCAPG antibody; Non SMC condensin I complex subunit G antibody; Non-SMC condensin I complex subunit G antibody; NY MEL 3 antibody; XCAP G homolog antibody; XCAP-G homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human hCAP-G.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 基因功能參考文獻：
    1. this study demonstrates that NCAPG plays an important role in the development and progression of hepatocellular carcinoma (HCC), and that it may be a novel therapeutic target for patients with HCC. PMID: 28737823
    2. Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets. PMID: 26933822
    3. Mutation of threonines 308 and 322 to alanines results in defects in CAP-G localization with chromosomes during mitosis. PMID: 18977199
  • 亞細胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    CND3 (condensin subunit 3) family
  • 組織特異性：
    Highly expressed in testis.
  • 數據庫鏈接：

    HGNC: 24304

    OMIM: 606280

    KEGG: hsa:64151

    STRING: 9606.ENSP00000251496

    UniGene: Hs.567567



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