在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NAT10 Antibody

  • 中文名稱:
    NAT10兔多克隆抗體
  • 貨號:
    CSB-PA088333
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA088333(NAT10 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA088333(NAT10 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 50 μg, Lane 1-3: A549 cells, K562 cells, hela cells, Primary antibody: CSB-PA088333(NAT10 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ALP antibody; DKFZp434C116 antibody; FLJ10774 antibody; FLJ12179 antibody; FLJ23850 antibody; hALP antibody; KIAA1709 antibody; N acetyltransferase 10 antibody; N acetyltransferase 10 GCN5 related antibody; N acetyltransferase like antibody; N acetyltransferase like protein antibody; N-acetyltransferase 10 antibody; NAT10 antibody; NAT10_HUMAN antibody; NET43 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human NAT10
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs. Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation. mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency. Mediates the formation of ac4C at position 1842 in 18S rRNA. May also catalyze the formation of ac4C at position 1337 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. The relevance of the protein lysine acetyltransferase activity is however unsure in vivo. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation.
  • 基因功能參考文獻:
    1. immunohistochemistry staining of NAT10 in hepatocellular carcinoma tissues demonstrates that the cytoplasmic NAT10 is correlated with poorer prognosis compared with nuclear NAT10, while the membranous NAT10 predicts the poorest clinical outcome of the patients. PMID: 29634924
    2. Increased NAT10 expression levels are associated with shortened hepatocellular carcinoma (HCC) patient survival and correlated with mutant p53 levels. NAT10 upregulates mutant p53 level and might enhance its tumorigenic activity. Hence, it is proposed that NAT10 could be a potential prognostic and therapeutic candidate for p53-mutated HCC. PMID: 28859621
    3. NAT10 is acetylated in vivo and autoacetylated in vitro PMID: 27993683
    4. NAT10 translocates to nucleoplasm to bind and acetylate p53 at K120 upon cellular stress. PMID: 26882543
    5. The subcellular redistribution of NAT10 can be induced by decreases in GSK-3b activity. This redistribution increases cancer cell motility, and is, thus, correlated with invasive potential and poorer clinical outcome PMID: 24982245
    6. Identification of NAT10 as responsible for both 18S rRNA and leucine/serine tRNA acetylation. PMID: 25653167
    7. NAT10 is an ATP-dependent RNA acetyltransferase responsible for formation of N(4)-acetylcytidine (ac(4)C) at position 1842 in the terminal helix of mammalian 18 S rRNA. PMID: 25411247
    8. we identified hALP, a histone acetyl-transferase as a novel t-UTP PMID: 21177859
    9. hALP is a nucleolar protein, and the nucleolar localization is mediated by its carboxy terminal domain. PMID: 18677378
    10. The investigation suggested that hALP influences the activity of histone acetylation and could up-regulate telomerase activity through transactivation of hTERT promoter. PMID: 14592445
    11. The above results suggested that NAT10 could be involved in DNA damage response and increased cellular resistance to genotoxicity. PMID: 17180247
    12. chromosome de-condensation needs the function of an inner nuclear membrane (INM) protein hsSUN1 and a membrane-associated histone acetyltransferase (HAT), hALP. PMID: 17631499
    13. NAT10 may play an important role in cell division through facilitating reformation of the nucleolus and midbody in the late phase of cell mitosis, and stabilization of microtubules. PMID: 19303003

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Midbody.
  • 蛋白家族:
    RNA cytidine acetyltransferase family, NAT10 subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 29830

    OMIM: 609221

    KEGG: hsa:55226

    STRING: 9606.ENSP00000257829

    UniGene: Hs.577281



主站蜘蛛池模板: 国产成年无码久久久久毛片| 无尺码精品产品国产| 久久精品国产成人午夜福利| 亚洲国产精品一区二区www| 久久国产精品-国产精品| 午夜福利理论片高清在线| 欧美自拍亚洲综合丝袜| 伊人亚洲大杳蕉色无码| 999国内精品永久免费视频 | 亚洲欧美中文高清在线专区| 国产精品久久久久久久久久免费看| 国内精品久久久久久中文字幕| 无遮挡十八禁污污网站免费| 中文无码第3页不卡av| 少妇无码一区二区三区免费| 国精品无码人妻一区二区三区| 日产日韩亚洲欧美综合下载| 国产老太睡小伙子视频| 大伊香蕉精品一区视频在线| 日本强伦姧人妻一区二区| 好日子在线观看视频大全免费动漫| 国产精品va在线播放| 丰满五十六十老熟女hd| 亚洲精品亚洲人成在线观看| 少妇大叫太大太爽受不了在线观看 | 日韩人妻一区二区三区免费| 日韩无套内射视频6| 成人看片黄a免费看| 一本加勒比波多野结衣| a片在线免费观看| 欧美人与动zozo在线播放| 免费无码又爽又刺激软件下载直播| 99精品人妻无码专区在线视频区| 亚洲精品色无码av试看| 99亚洲精品自拍av成人| 亚洲另类无码一区二区三区| 免费无码一区二区三区蜜桃大| 老男人久久青草av高清| 精品亚洲麻豆1区2区3区| 美女张开腿黄网站免费下载| 午夜内射中出视频|