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  4. NAPEPLD Antibody, FITC conjugated

NAPEPLD Antibody, FITC conjugated

  • 中文名稱：
    NAPEPLD兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA764247LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NAPEPLD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NAPEPLD
  • 別名：
    C7orf18 antibody; DKFZp781D1098 antibody; FMP30 antibody; Mbldc1 antibody; N acyl phosphatidylethanolamine hydrolyzing phospholipase D antibody; N acyl phosphatidylethanolamine phospholipase D antibody; N-acyl phosphatidylethanolamine phospholipase D antibody; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D antibody; NAPE hydrolyzing phospholipase D antibody; NAPE-hydrolyzing phospholipase D antibody; NAPE-PLD antibody; NAPEP_HUMAN antibody; NAPEPLD antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D protein (1-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.
  • 基因功能參考文獻：
    1. The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia. PMID: 29652995
    2. NAPE-PLD forms homodimers partly separated by an internal channel and uniquely adapted to associate with phospholipids. PMID: 25684574
    3. our results do not support a clear role of FAAH, CNR1 and NAPE-PLD in BD and lithium response. PMID: 24126189
    4. a major physiological role of NAPE-PLD PMID: 24018423
    5. The differential expression of NAPE-PLD and FAAH suggests that Anandamide could play an important role in the pathophysiology of preeclampsia. PMID: 23122699
    6. NAPE-PLD expression increase steadily after infancy, peaking in adulthood. PMID: 22827915
    7. The results of this study suggested that NAPEPLD was alterated in multip;e sclerosis. PMID: 21251115
    8. a common haplotype in NAPEPLD, an enzyme involved in endocannabinoid synthesis, was protective against obesity. PMID: 20885390
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20885390
    10. During the menstrual cycle, NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. PMID: 20369362
    11. The human NAPE-PLD was activated by phosphatidylethanolamine and inhibited by the beta-lactamase substrate nitrocefin. PMID: 19715685

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  • 亞細胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Nucleus envelope. Nucleus, nucleoplasm.
  • 蛋白家族：
    NAPE-PLD family
  • 組織特異性：
    Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).
  • 數據庫鏈接：

    HGNC: 21683

    OMIM: 612334

    KEGG: hsa:222236

    STRING: 9606.ENSP00000340093

    UniGene: Hs.324271



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