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  4. NANOS3 Antibody, FITC conjugated

NANOS3 Antibody, FITC conjugated

  • 中文名稱：
    NANOS3兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA015438LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NANOS3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NANOS3
  • 別名：
    NANO3_HUMAN antibody; Nanos homolog 3 antibody; NANOS3 antibody; NOS-3 antibody; Nos3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Nanos homolog 3 protein (21-192AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
  • 基因功能參考文獻：
    1. despite the prominent role of NANOS3 in ovarian development, our findings suggest that NANOS3 mutations were not associated with POF in the present cohort of Brazilian women. PMID: 28076512
    2. data can be used to further elucidate the role of NANOS3 and DAZL in germ cell development both in vitro and in vivo PMID: 27768780
    3. NANOS3 has role in the acquisition of invasiveness by human lung tumour cells and propose a new mechanism of post-transcriptional regulation of epithelial-mesenchymal transition. PMID: 25904364
    4. an inactivating missense mutation in NANOS3 has a role in primary ovarian insufficiency that involves increased primordial germ cell apoptosis during embryonic cell migration PMID: 25054146
    5. NANOS3 mutation is one possible cause of primary ovarian insufficiency. PMID: 24091668
    6. NANOS3 modulates essential aspects of human germ cell development perhaps during the cell cycle. PMID: 21421998
    7. Mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure. PMID: 17418157
    8. Report for the first time analysis of the NANOS3 gene in infertile males. PMID: 19565640
    9. Observational study of genotype prevalence. (HuGE Navigator) PMID: 17418157

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
  • 蛋白家族：
    Nanos family
  • 組織特異性：
    Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, ty
  • 數據庫鏈接：

    HGNC: 22048

    OMIM: 608229

    KEGG: hsa:342977

    UniGene: Hs.127982



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