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  4. MYT1 Antibody

MYT1 Antibody

  • 中文名稱：
    MYT1兔多克隆抗體
  • 貨號：
    CSB-PA015387LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA015387LA01HU diluted at 1:300 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MYT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C20orf36 antibody; KIAA0835 antibody; KIAA1050 antibody; MTF1 antibody; Myelin transcription factor 1 antibody; Myelin transcription factor I antibody; MYT1 antibody; MYT1_HUMAN antibody; MyTI antibody; PLPB1 antibody; Proteolipid protein-binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Myelin transcription factor 1 protein (317-451AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MYT1 Antibody (CSB-PA015387LA01HU)，的標記方式是Non-conjugated。對于MYT1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA015387LB01HU MYT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA015387LC01HU MYT1 Antibody, FITC conjugated
    Biotin CSB-PA015387LD01HU MYT1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
  • 基因功能參考文獻：
    1. A novel missense variant affecting function, c.323C>T (p.(Ser108Leu)), was identified in MYT1, in a patient presenting with a severe form of OAVS. MYT1 overexpression downregulated all RA receptors genes in vitro. PMID: 28612832
    2. although depletion of MYT1 alone did not affect long-term cell growth, it potentiated with DNA damage to inhibit cell growth in clonogenic survival and tumor xenograft models PMID: 23146904
    3. present in brain in infancy and prenatally in infants with periventricular leukomalacia PMID: 12524179
    4. These results suggesta potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination. PMID: 17330875
    5. UVA-induced caspase-3 cleavage and DNA fragmentation were suppressed by the knockdown of human Myt1 in skin cancer cells. PMID: 19204086

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    MYT1 family
  • 組織特異性：
    Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
  • 數據庫鏈接：

    HGNC: 7622

    OMIM: 600379

    KEGG: hsa:4661

    STRING: 9606.ENSP00000327465

    UniGene: Hs.279562



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