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MYSM1 Antibody

  • 中文名稱:
    MYSM1兔多克隆抗體
  • 貨號:
    CSB-PA003355
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of MCF7 cells using MYSM1 Polyclonal Antibody
    • Western Blot analysis of MCF7 cells using MYSM1 Polyclonal Antibody
    • Western blot analysis of Hela lysis using MYSM1 antibody.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MYSM1
  • 別名:
    2A-DUB antibody; 2ADUB antibody; Histone H2A deubiquitinase antibody; Histone H2A deubiquitinase MYSM1 antibody; KIAA1915 antibody; Myb like SWIRM and MPN domains 1 antibody; Myb like, SWIRM and MPN domain containing protein antibody; Myb like, SWIRM and MPN domains 1 antibody; Myb-like antibody; Myb-like, SWIRM and MPN domains 1 antibody; MYSM 1 antibody; mysm1 antibody; MYSM1 Myb-like, SWIRM and MPN domains 1 antibody; MYSM1_HUMAN antibody; RP4-592A1.1 antibody; SWIRM and MPN domain-containing protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human MYSM1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome.
  • 基因功能參考文獻:
    1. Data indicate a pathway MYSM1/miR-150/FLT3 that inhibits proliferation of B1a cells, which may be involved in the pathogenesis of systemic lupus erythematosus (SLE). PMID: 27590507
    2. this study shows that MYSM1 deficiency is associated with developmental aberrations, progressive bone marrow failure with myelodysplastic features, and increased susceptibility to genotoxic stress PMID: 28115216
    3. data suggested that expression of MYSM1 was associated with the progression of CRC and might be a potential biomarker for clinical prognosis PMID: 28498834
    4. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation PMID: 26220525
    5. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings PMID: 24288411
    6. The SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1), is reported. PMID: 17428495
    7. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported. PMID: 17707232

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  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Peptidase M67A family, MYSM1 subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 29401

    OMIM: 612176

    KEGG: hsa:114803

    STRING: 9606.ENSP00000418734

    UniGene: Hs.744921



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