在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MYSM1 Antibody

MYSM1 Antibody

  • 中文名稱：
    MYSM1兔多克隆抗體
  • 貨號：
    CSB-PA003355
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of MCF7 cells using MYSM1 Polyclonal Antibody
    • Western Blot analysis of MCF7 cells using MYSM1 Polyclonal Antibody
    • Western blot analysis of Hela lysis using MYSM1 antibody.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MYSM1
  • 別名：
    2A-DUB antibody; 2ADUB antibody; Histone H2A deubiquitinase antibody; Histone H2A deubiquitinase MYSM1 antibody; KIAA1915 antibody; Myb like SWIRM and MPN domains 1 antibody; Myb like, SWIRM and MPN domain containing protein antibody; Myb like, SWIRM and MPN domains 1 antibody; Myb-like antibody; Myb-like, SWIRM and MPN domains 1 antibody; MYSM 1 antibody; mysm1 antibody; MYSM1 Myb-like, SWIRM and MPN domains 1 antibody; MYSM1_HUMAN antibody; RP4-592A1.1 antibody; SWIRM and MPN domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MYSM1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome.
  • 基因功能參考文獻：
    1. Data indicate a pathway MYSM1/miR-150/FLT3 that inhibits proliferation of B1a cells, which may be involved in the pathogenesis of systemic lupus erythematosus (SLE). PMID: 27590507
    2. this study shows that MYSM1 deficiency is associated with developmental aberrations, progressive bone marrow failure with myelodysplastic features, and increased susceptibility to genotoxic stress PMID: 28115216
    3. data suggested that expression of MYSM1 was associated with the progression of CRC and might be a potential biomarker for clinical prognosis PMID: 28498834
    4. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation PMID: 26220525
    5. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings PMID: 24288411
    6. The SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1), is reported. PMID: 17428495
    7. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported. PMID: 17707232

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Peptidase M67A family, MYSM1 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29401

    OMIM: 612176

    KEGG: hsa:114803

    STRING: 9606.ENSP00000418734

    UniGene: Hs.744921



主站蜘蛛池模板： 亚洲欧洲国产综合aⅴ无码| 韩国精品一区二区三区四区| 丝袜自慰一区二区三区| 国精品午夜福利视频导航| 99久久国产综合精品五月天喷水| 里番本子纯肉侵犯肉全彩无码| 免费看成人欧美片爱潮app| 青青草国产线观看| 18禁黄久久久aaa片| 四虎国产精品永久地址49| 亚洲国产精品一区二区成人片国内| 免费ā片在线观看| 一二三四视频社区在线播放中国 | 在线视频 亚太 国产 欧美 一区二区| 久久精品青青草原伊人| 国产午夜精品一区二区三区不卡 | 亚洲 日本 欧美 中文幕| 亚洲成av人综合在线观看| 亚洲电影天堂av2017| 好紧好爽好深再快点av在线 | 国产欧美日韩综合精品二区 | 天天摸天天做天天爽天天弄| 四虎成人精品永久网站| 久久狠狠高潮亚洲精品| 四虎影视在线影院在线观看| 国产精品亚洲综合色区| 亚洲色欲色欲大片www无码| 久久婷婷五月综合色丁香| 无码h黄动漫在线播放网站| 日本一道高清一区二区三区| 午夜三级a三级三点窝| 全部av―极品视觉盛宴| 国内精品久久久久久久影院| 国产成人精品无码免费看| 国产精品情侣呻吟对白视频| 成人无码嫩草影院| 亚洲欧美日韩国产国产a| 人妻 日韩 欧美 综合 制服| 人妻少妇精品专区性色av| 亚洲精品午夜久久久伊人| 国产精品美女久久久久久久久|