在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MYO9B Antibody

  • 中文名稱:
    MYO9B兔多克隆抗體
  • 貨號:
    CSB-PA273051
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells and Jurkat cells, using MYO9B antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MYO9B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MYO9B
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human MYO9B.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA.
  • 基因功能參考文獻:
    1. Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease. PMID: 28627089
    2. data indicate that polymorphisms in MY09B are associated with the risk of inflammatory bowel disease PMID: 27556856
    3. Mutating either of the two arginine fingers impaired the catalytic activity of Myo9b-RhoGAP. PMID: 27363609
    4. meta-analysis indicates that MYO9B gene polymorphisms might be not associated with coeliac disease susceptibility in Caucasians. [meta-analysis] PMID: 27219348
    5. this meta-analysis shows that MYO9B genetic polymorphism is associated with Crohn's disease and ulcerative colitis PMID: 27435931
    6. newly defined SLIT/ROBO/Myo9b/RhoA signaling pathway that restricts lung cancer progression and metastasis. PMID: 26529257
    7. Our data suggest a link between MYO9B variants to an increased intestinal permeability in Crohn's disease patients. PMID: 25098938
    8. Results does not support the association of MYO9B with schizophrenia in Chinese population. PMID: 25710847
    9. MYO9B SNPs may influence the sub-phenotypic expression of Crohn's disease but did not find an association between these MYO9B polymorphisms and intestinal permeability in IBD. PMID: 24966617
    10. Variants in MYO9B may be involved in acute pancreatitis PMID: 24386489
    11. genetic variation MYO9B gene is associated with celiac disease as a protective or a risk factor PMID: 23368647
    12. The homozygous G/G group of theMyo9B polymorphism was associated with an increased risk for Barrett's esophagus and esophageal adenocarcinoms (EAC) development. Also the heterozygous A/G genotype was associated with an increased risk for EAC development. PMID: 22954106
    13. critical roles for Myo9b during epithelial wound healing and maintenance of tight junction integrity-key functions that may be altered in patients with Myo9b-linked inflammatory bowel disease. PMID: 22573889
    14. we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia found no evidence for association with these two loci. PMID: 21688385
    15. These data demonstrate an association of MYO9B with ileal CD. PMID: 21515326
    16. gene polymorphism is associated with type i diabetes in Dutch but not in Brotosh population PMID: 20303373
    17. Myosin-IXb is a single-headed and processive motor PMID: 11801597
    18. myosin IXb binds to BIG1, which regulates its Rho-GTPase activating protein activity PMID: 15644318
    19. Individuals homozygous with respect to the at-risk allele have a 2.3-times higher risk of celiac disease (P = 1.55 x 10(-5)). PMID: 16282976
    20. myosin IX uses a unique ATP hydrolysis mechanism PMID: 16338935
    21. Genotyping of the three SNPs which tagged the associated haplotype was performed in a Celiac disease family dataset in a Swedish/Norwegian cohort. PMID: 16720215
    22. tested the association between celiac disease and the three most associated single nucleotide polymorphisms by the transmission disequilibrium test in the Italian population PMID: 16943798
    23. Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. PMID: 17087940
    24. Results support a negligible influence of MYO9B polymorphisms on celiac disease predisposition. PMID: 17176439
    25. The MYO9B gene rs 2305764 polymorphism is not associated to coeliac disease in coeliac children from southern Italy. The allelic frequences of the polymorphism found in these patients and in the population control were not statistically different. PMID: 17267307
    26. study suggests that genetic variation in MYO9B is associated with celiac disease, systemic lupus erythematosus, and rheumatoid arthritis and that MYO9B is a general risk factor for autoimmunity PMID: 17584584
    27. Our data and the results of our meta-analysis question the role of MYO9B as a causative gene for celiac disease. PMID: 17667713
    28. study did not confirm the association of celiac disease with the CELIAC4 region polymorphisms described in other populations PMID: 17767555
    29. demonstrate significant association of allelic variants in MYO9B with schizophrenia. To our knowledge, this is the first molecular genetic evidence for a correlation between autoimmune diseases and the risk of developing schizophrenia PMID: 17948900
    30. MYO9B homozygosity might be involved in the prognosis of CD and the chance of developing RCD II and EATL. PMID: 17967566
    31. Myosin IXB variants were not associated with coeliac disease in this study; however, weak evidence of association with dermatitis herpetiformis was found. PMID: 18077767
    32. Minor alleles of rs962917, rs2279003, and rs2305764 polymorphisms were more frequent in diabetic patients than in controls and the haplotype carrying major alleles in rs962917*G/rs2279003*C/rs2305764*G, significantly reduced the risk of type 1 diabetes PMID: 18361936
    33. No association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations PMID: 19142207
    34. MYO9B variants may be involved in inflammatory bowel disease pathogenesis PMID: 19235913

    顯示更多

    收起更多

  • 相關疾病:
    Celiac disease 4 (CELIAC4)
  • 亞細胞定位:
    Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 組織特異性:
    Detected in peripheral blood leukocytes (at protein level). Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung.
  • 數據庫鏈接:

    HGNC: 7609

    OMIM: 602129

    KEGG: hsa:4650

    STRING: 9606.ENSP00000380444

    UniGene: Hs.123198



主站蜘蛛池模板: 国产美女嘘嘘嘘嘘嘘| 久久久久无码国产精品不卡| 久久久久欧美精品| 久久综合九色综合97伊人| 成人av片在线观看免费| 亚洲国产另类久久久精品| 国产乱人伦在线播放| 麻豆果冻国产剧情av在线播放| 国语对白刺激精品视频| 亚洲欧美成aⅴ人在线观看| 福利姬液液酱喷水| 乱码视频午夜间在线观看| 四虎国产精品永久地址49| 精品人妻少妇一区二区三区| 2018av天堂在线视频精品观看| 日本japanese丰满白浆| 欧美品无码一区二区三区在线蜜桃| 国产成人无码激情视频| 国产精品久久久久久av| 亚洲人成精品久久久久| 无码国产成人午夜电影观看| 久久中文字幕人妻熟女| 久久久久久人妻无码| 国产成人无码av在线影院| 久久理论片午夜琪琪电影网| 玩两个丰满老熟女| 国产精品视频白浆免费视频| 国产精品sm捆绑调教视频| 色综合视频一区二区三区44| 国产又粗又猛又大爽又黄| 小雪好紧好滑好湿好爽视频| 人妻无码中文字幕永久在线| 国产av一区二区三区日韩| 337p西西人体大胆瓣开下部| 色一情一乱一乱一区99av| 亚洲精品成人网站在线观看 | 免费无码av片在线观看潮喷| 国产成人8x人网站在线视频| 免费大片黄在线观看| 国产亚洲欧美日韩夜色凹凸成人| 久久亚洲人成电影网|