在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MYO5A Antibody, Biotin conjugated

  • 中文名稱:
    MYO5A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA857430LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MYO5A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MYO5A
  • 別名:
    non-muscle antibody; Dilute myosin heavy chain antibody; GS1 antibody; MYH12 antibody; MYO5 antibody; Myo5a antibody; MYO5A_HUMAN antibody; Myosin heavy chain 12 antibody; Myosin heavy polypeptide kinase antibody; Myosin V antibody; Myosin VA (heavy polypeptide 12 myoxin) antibody; Myosin VA (heavy polypeptide 12 myoxin) antibody; Myosin-12 antibody; Myoxin antibody; MYR12 antibody; Unconventional myosin-Va antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Unconventional myosin-Va protein (1087-1220AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.
  • 基因功能參考文獻:
    1. our studies revealed RPGRIP1L as a novel MyoVa-binding protein - the first to be demonstrated to interact with MyoVa at the centrosome - and uncover an unprecedented link between MyoVa and ciliogenesis, providing new perspectives for studies aiming to better understand why defects in MyoVa cause neurological disorders in Griscelli syndrome patients. PMID: 28266547
    2. MYO5A, having rare amino acid mutations p.R849Q and p.V1601G, was involved in the biological network of known MODY genes. PMID: 29670293
    3. the essential melanocyte-specific transcription factor MITF regulates expression of the MYO5A gene, which encodes the molecular motor myosin-Va. PMID: 27939378
    4. human cytomegalovirus capsids associate with nuclear myosin Va and F-actin and that antagonism of myosin Va impairs capsid localization toward the nuclear rim and nuclear egress. PMID: 29298889
    5. Mechanochemical cycle of myosin-V has been reported. PMID: 28193897
    6. Data suggest that membrane tethering mediated by endosomal RAB11A is drastically and selectively stimulated by its cognate Rab effectors, class V myosins (MYO5A and MYO5B), in a GTP-dependent manner. (RAB11A = ras-related GTPase Rab-11A; MYO5 = myosin class V) PMID: 28939769
    7. ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions are identified in Spitz tumours and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase Cgamma1 pathways in melanocytes. PMID: 27477320
    8. the inhibited Myo5a is equilibrated between the folded state, in which the Mlph-binding site is buried, and the preactivated state, in which the Mlph-binding site is exposed, and that Mlph is able to bind to the Myo5a in preactivated state and activates its motor function. PMID: 27129208
    9. These findings reveal a new fast-acting energy conservation strategy halting growth by immobilizing myosin V in a newly described state on selectively stabilized actin cables. PMID: 25308080
    10. Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c. PMID: 24339992
    11. Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
    12. several crystal structures of the myosin Va or the myosin Vb globular tail domain that gives insights into how the motor is linked to the recycling membrane compartments via Rab11 or the melanophilin adaptor that binds to Rab27a. PMID: 24248336
    13. the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb, and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process PMID: 24097982
    14. myosin-Va promotes adhesion dynamics, anchorage-independent survival, migration, and invasion in vitro PMID: 23652798
    15. Myosin Va plays a role in the transport and turnover of mRNA. [Review] PMID: 23176491
    16. Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a. PMID: 22437832
    17. A Rab27a/MyRIP/myosin Va complex is involved in linking von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of vWF. PMID: 21740491
    18. Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
    19. Myosin Va is required for P body but not stress granule formation. PMID: 21245139
    20. Myo5a is activated in cells during HSV-1 infection to help transport virion- and glycoprotein-laden vesicles from the TGN, through the cortical actin, to the plasma membrane. PMID: 20631136
    21. MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells PMID: 20203291
    22. Myosin-Va has a role in restraining Na(+)/K(+)-ATPase-containing vesicles within intracellular pools. PMID: 19808891
    23. role of function in melanosome transport PMID: 11980908
    24. MYO5A mutations in Griscelli disease PMID: 12148598
    25. Interactions of human Myosin Va isoforms in human melanocytes are tightly regulated by the tail domain. Interaction with rab27a and melanophilin. Myosin Va medial tail domain provides the globular tail domain with organelle-interacting specificity. PMID: 12603861
    26. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). PMID: 12897212
    27. the endosome-associated protein hrs is a subunit of a protein complex containing actinin-4, BERP, and myosin V that is necessary for efficient TfR recycling but not for EGFR degradation PMID: 15772161
    28. MYO5A transports dense core secretory vesicles in pancreatic MIN6 beta-cells. PMID: 15788565
    29. exon B and its associated dynein light chain have a significant effect on the structure of parts of the coiled-coil tail domains and such a way could influence the regulation and cargo-binding function of myosin Va PMID: 17029413
    30. present a kinetic model for the walking of myosin V on actin PMID: 17487986
    31. Data suggest that myosin-V makes two brownian 90 degrees rotations per 36-nm step as it processively walks on actin filaments in a hand-over-hand fashion. PMID: 17891151
    32. MyoVa directly mediates stable attachment of secretory granules at the plasma membrane. PMID: 17898234
    33. Specific knockdown of MyoVa exon F isoforms resulted in transport inhibition of melanosomes to peripheral subcortical actin network in dendrite tips; perinuclear aggregation of melanosomes. May become innovative drug to treat hyperpigmentation. PMID: 18401430
    34. During primate spermiogenesis, dynein, myosin Va, MyRIP and Rab27b that compose microtubule-based and actin-based vesicle transport systems are actually present in the manchette and might possibly be involved in intramanchette transport. PMID: 18478159
    35. related Rab protein, Rab10, can interact with myosin Va, myosin Vb, and myosin Vc PMID: 19008234
    36. data demonstrate an essential role of myosin Va in cancer cell migration and metastasis, and suggest a novel target for Snail in its regulation of cancer progression PMID: 19521958

    顯示更多

    收起更多

  • 相關疾病:
    Griscelli syndrome 1 (GS1); Griscelli syndrome 3 (GS3); Elejalde syndrome (ELEJAS)
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 組織特異性:
    Detected in melanocytes.
  • 數據庫鏈接:

    HGNC: 7602

    OMIM: 160777

    KEGG: hsa:4644

    STRING: 9606.ENSP00000382177

    UniGene: Hs.21213



主站蜘蛛池模板: 精品免费国偷自产在线视频| 亚洲和欧洲一码二码区别7777| 尤物国精品午夜福利视频| 成人免费乱码大片a毛片| 色欲色香天天天综合vvv| 欧美孕妇变态重口另类| 日韩去日本高清在线| 综合 欧美 小说 另类 图| 四虎成人精品无码| 狠狠色噜噜狠狠狠888米奇视频| 少妇激情av一区二区三区 | 国产精品av在线| 亚洲国产精品成人天堂| 国产区又黄又硬高潮的视频| 四虎成人国产精品永久在线| av无码一区二区三区| 免费看美女被靠到爽的视频| 天天看片天天av免费观看| 欧美精品亚洲精品日韩专区一乛方| 一本大道伊人av久久乱码| 国产精品亚洲一区二区三区| 性欧美丰满熟妇xxxx性5| 五月丁香综合激情六月久久| 国产免费无遮挡吸奶头视频| 国产av久久人人澡人人爱| 亚洲欧美在线观看品| 成人无码精品1区2区3区免费看| аⅴ天堂中文在线网官网| 中国人妻被两个老外三p| 2019最新中文字幕在线观看| 久久精品无码中文字幕| 国产成人一区二区三区在线观看| 国产亚洲欧美日韩在线观看一区 | 人妻熟人中文字幕一区二区| 国产va免费精品观看| 国产偷国产偷亚洲清高app| 国产精品久久久久野外| 动漫av一区二区在线观看| 亚洲色欲色欲www在线看| 18禁成人网站免费观看| 重口sm一区二区三区视频|