在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MYH11 Antibody, Biotin conjugated

  • 中文名稱:
    MYH11兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA015291LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MYH11 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AAT4 antibody; DKFZp686D10126 antibody; DKFZp686D19237 antibody; FAA4 antibody; FLJ35232 antibody; MGC126726 antibody; MGC32963 antibody; MYH 11 antibody; MYH11 antibody; MYH11_HUMAN antibody; Myosin 11 antibody; Myosin heavy chain 11 antibody; Myosin heavy chain 11 smooth muscle antibody; Myosin heavy chain antibody; Myosin heavy chain smooth muscle isoform antibody; Myosin heavy polypeptide 11 smooth muscle antibody; Myosin-11 antibody; SMHC antibody; SMMHC antibody; smooth muscle isoform antibody; Smooth muscle myosin heavy chain 11 isoform SM2 antibody; Smooth muscle myosin heavy chain isoform SM2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Myosin-11 protein (1655-1797AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Muscle contraction.
  • 基因功能參考文獻:
    1. the presented study demonstrates that CBFB-MYH11-based MRD status during the first 3 months after allo-HCT, but not KIT mutations, can be used to identify patients with a high risk of relapse. PMID: 27650511
    2. In patients with MYH11 or ACTA2 variants, the effect of intronic variants on splicing was demonstrated on the mRNA level in the induced smooth muscle cell (SMC), allowing classification into pathogenic or nonpathogenic variants. PMID: 28074631
    3. Deletion mutation in MYH11 gene causing familial Thoracic aortic dissection was identified in two independent Japanese pedigrees. PMID: 26056961
    4. Data suggest that expression of MYH11, myosin light chain, and MLCK (myosin-light-chain kinase), is up-regulated in uterine myoma as compared to adjacent smooth muscle cells; expression of MYH11 appears to be involved in cell proliferation. PMID: 25181625
    5. In familial AAA we found one pathogenic and segregating variant (COL3A1 p.Arg491X), one likely pathogenic and segregating (MYH11 p.Arg254Cys), and fifteen VUS. PMID: 26017485
    6. CBFB contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB-SMMHC in proliferation and maintenance of the leukemic phenotype. PMID: 25079347
    7. we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation PMID: 25266220
    8. overexpression of MYH11 can lead to increased ER stress and autophagy PMID: 24711452
    9. MYH11 gene mutation is associated with family history of thoracic aortic aneurysm dissection. PMID: 24921172
    10. Transcriptional analysis revealed that upon fusion protein knockdown, a small subset of the CBFbeta-MYH11 target genes show increased expression, confirming a role in transcriptional repression PMID: 24002588
    11. MYH11 mutations are rare and are identified in patients with thoracic aortic aneurysm/dissection. PMID: 21937134
    12. Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus. PMID: 22968129
    13. We conclude that non-type A CBFB-MYH11 fusion types associate with distinct clinical and genetic features, including lack of KIT mutations, and a unique gene-expression profile in acute myeloid leukemia PMID: 23160462
    14. Our data indicate that the CBFbeta-SMMHC's C-terminus is essential to induce embryonic hematopoietic defects and leukemogenesis. PMID: 23152542
    15. A rare variant in MYH11, R247C, alters myosin contractile function and smooth muscle cell phenotype, leading to increased proliferation in vitro and in response to vascular injury. PMID: 22511748
    16. Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations. PMID: 22001912
    17. increased MYH11 expression was found in aortic tissues from TAAD patients with 16p13.1 duplications compared with control aortas. PMID: 21698135
    18. Data show that the purified hMDCs cultured in SMIM for 4 weeks and expressed significant amount of smooth muscle myosin heavy chain and alpha-smooth muscle actin. PMID: 20132408
    19. Data suggest that that hASMCs contain a significant pool of functional SMM in the 10S conformation that can assemble into filaments upon changing cellular conditions. PMID: 21205888
    20. CBFB-MYH11 rearrangement is associated with acute myeloid leukemia. PMID: 20508610
    21. leukemogenic fusion gene (with Cbfb) plays a role in hematopoiesis PMID: 12239155
    22. Plag1 and Plagl2 are novel leukemia oncogenes that act by expanding hematopoietic progenitors expressing CbF beta-SMMHC. PMID: 15585652
    23. Human MYH11 gene mutations provide the first example of a direct change in a specific smooth muscle cell protein leading to an inherited arterial diseases PMID: 16444274
    24. Detection of acute myeloid leukemic cells that are characterized by a CBFB-MYH11 gene fusion. PMID: 16502584
    25. These observations suggest that when abdominal GS is diagnosed, an analysis of the CBFB/MYH11 fusion gene is necessary to make an appropriate decision regarding treatment options, even if no chromosomal abnormalities are found. PMID: 16504290
    26. Agents interacting with the outer surface of the CBFbeta-SMMHC ACD that prevent multimerization may be effective as novel therapeutics in AML PMID: 16767164
    27. Rare fusion transcripts were correlated with an atypical cytomorphology not primarily suggestive for the FAB subtype acute myelocytic leukemia. PMID: 17287858
    28. Examine consequences of expression of abnormal chimeric protein CBFbeta-MYH11 in acute myelomonocytic leukemia. PMID: 17571080
    29. MYH11 mutations are likely to be specific to the phenotype of thoracic aortic aneurysms and dissections associated with patent ductus arteriosus and result in a distinct aortic and occlusive vascular pathology potentially driven by IGF-1 and Ang II. PMID: 17666408
    30. MYH11 gene is involved in only rare instances when persistent patency of the arterial duct occurs in sporadic fashion. PMID: 17956658
    31. MYH11 mutations in patients with colorectal cancer, Peutz-Jeghers syndrome and juvenile polyposis . PMID: 18391202
    32. Little evidence for a role of somatic MYH11 mutations in the formation of breast or prostate cancers PMID: 18796164
    33. three novel amino acid substitutions in MYH11 in AML samples, located in the highly conserved myosin head and rod essential for motor function and regulation of MYH11 PMID: 18798114
    34. MYH11 mutation is not required for early hereditary nonpolyposis colorectal cancer adenoma formation, but it is selected for in the process of microsattelite instability positive cancer tumorigenesis. PMID: 18941465
    35. Selective overexpression of airway smooth muscle genes in asthmatic airways leads to increased Vmax, thus contributing to the airway hyperresponsiveness observed in asthma. PMID: 19011151
    36. sequence deletion in Pseudoxanthoma elasticum PMID: 11439001

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Aortic aneurysm, familial thoracic 4 (AAT4)
  • 亞細胞定位:
    Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 組織特異性:
    Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.
  • 數據庫鏈接:

    HGNC: 7569

    OMIM: 132900

    KEGG: hsa:4629

    STRING: 9606.ENSP00000379616

    UniGene: Hs.460109



主站蜘蛛池模板: 在线亚洲人成电影网站色www| 国产一卡2卡3卡四卡精品国色无边| 日韩 高清 无码 人妻| 国产裸体xxxx视频| 亚洲日本精品国产一区vr| 国产亚洲色欲色一色www| 国产乱人伦中文无无码视频试看| 国产精品美女久久久| 亚洲精品久久久久久动漫器材一区| 国产超碰无码最新上传| 天堂va欧美ⅴa亚洲va在线| 999久久久国产精品| 免费国精产品—品二品| 小宝贝荡货啊用力水湿aⅴ视频 | 亚洲精品尤物av在线观看不卡| 人妻激情另类乱人伦人妻| 中国老熟女重囗味hdxx| 久久中文精品无码中文字幕| 亚洲欧美v国产一区二区| 成人一区二区免费视频| 精品国产乱码久久久久久影片| 亚洲中文字幕婷婷在线| 国产美女视频国产视视频| 国产在线视频一区二区三区| 国产剧情国产精品一区| 麻豆蜜桃av蜜臀av色欲av| 国产亚洲精品视觉盛宴| 亚洲人成网站在小说| 无码成人一区二区三区| 国产日韩av无码免费一区二区| 久久国内精品自在自线图片| 国产在线精品一区二区中文| 久久久不卡国产精品一区二区| 欧美日韓性视頻在線| 熟女人妻av完整一区二区三区| 波多野结衣av无码久久一区| 青青青国产免a在线观看| 97热久久免费频精品99| 无码人妻一区二区三区线| 久久精品无码一区二区日韩av| 高潮爽死抽搐白浆gif视频|