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  4. MXI1 Antibody, FITC conjugated

MXI1 Antibody, FITC conjugated

  • 中文名稱：
    MXI1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA015254LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MXI1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MXI1
  • 別名：
    bHLHc11 antibody; Class C basic helix-loop-helix protein 11 antibody; MAD 2 antibody; MAD2 antibody; MAX dimerization protein 2 antibody; MAX interacting protein 1 antibody; Max interactor 1 antibody; Max related transcription factor antibody; MAX-interacting protein 1 antibody; MGC43220 antibody; MXD 2 antibody; MXD2 antibody; MXI 1 antibody; MXI antibody; mxi1 antibody; MXI1 protein antibody; MXI1_HUMAN antibody; Protein MXI1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Max-interacting protein 1 protein (75-173AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
  • 基因功能參考文獻(xiàn)：
    1. Reactive oxygen species mediates hypoxia-induced VEGF by upregulation of Mxi1-0. PMID: 28065785
    2. results suggest that Mxi1-0 regulates the growth of HUVECs via the IL-8 and ERK1/2 pathways, which apparently reciprocally activate each other PMID: 28575053
    3. MYC-HEG and MXI1-LEG levels are associated with poor prognosis in patients with breast cancer, suggesting that they may be useful molecular markers in breast cancer prognosis prediction. PMID: 24685915
    4. MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1. PMID: 24376632
    5. MXI1-0 appears to be a downstream target of MYCN-dependent signaling pathways and may contribute to N-Myc-dependent cell growth and proliferation. PMID: 24403858
    6. These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1. PMID: 23254855
    7. Mxi1 can act as a tumour suppressor in human glioblastomas through a molecular mechanism involving the transcriptional down-regulation of cyclin B1 gene expression. PMID: 11875718
    8. These findings support MXI1 as a putative tumor suppressor gene involved in conventional melanoma progression. PMID: 14559981
    9. Mxi1-SRalpha is an isoform with enhanced transcriptional repression potential PMID: 15467743
    10. Data show that PTEN and MXI1 were two candidate tumor suppressor genes on 10q23 and 10q24-q25 and may be potentially involved in the initiation and progression of prostate carcinoma. PMID: 15476185
    11. Mxi-D may play an important role in the c-Myc family protein network acting as a dominant negative isoform of Mxi-F stimulated by c-Myc PMID: 15809730
    12. p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 PMID: 16126174
    13. MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma. PMID: 17102621
    14. These results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function. PMID: 17452451
    15. Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. PMID: 17577784
    16. Mxi1 gains functional complexity by encoding isoforms with shared and distinct activities PMID: 17697116
    17. Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. PMID: 18457265
    18. Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis PMID: 19018165
    19. MAX interactor-1 (MXI1) gene is directly regulated by HIF-1alpha protein in neuroblastoma and breast cancer cells. PMID: 19254710

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  • 相關(guān)疾病：
    Prostate cancer (PC)
  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 7534

    OMIM: 176807

    KEGG: hsa:4601

    STRING: 9606.ENSP00000331152

    UniGene: Hs.602078



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