在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MX2 Antibody

  • 中文名稱:
    MX2兔多克隆抗體
  • 貨號:
    CSB-PA931467
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from 293 cells, using MX2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MX2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MX2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from Internal of Human MX2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
  • 基因功能參考文獻:
    1. Study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. PMID: 29773792
    2. These data demonstrate that human MXB but not other human or murine MX proteins inhibit murine cytomegalovirus propagation. Evidently, the viral protein expression was delayed and the viral DNA amount in nucleus was diminished in MXB expressing cells indicating an obstruction of nuclear entry. PMID: 30032029
    3. Therefore, these results demonstrate the importance of MxB in alpha interferon-mediated inhibition of HIV-1 infection. PMID: 29925663
    4. The dynamin-like MxB GTPase serves as a broadly acting intracellular restriction factor that controls retrovirus as well as herpesvirus infections. PMID: 29950411
    5. MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. [review] PMID: 27492442
    6. These experiments suggested that MxB does not contribute to the HIV-1 restriction observed in IFN-alpha-treated human cells. PMID: 26719253
    7. Together, the data demonstrate that interferon-beta inhibits foamy virus early in infection and that MxB is not a restriction factor of foamy virus. PMID: 26609934
    8. We propose that lower-order oligomerization of MX2 is sufficient for the effective inhibition of human immunodeficiency virus type 1. PMID: 26446602
    9. Study analyzed the evolutionary history of MX2 at the inter- and intraspecific level and use this information to identify a haplotype that associates with natural resistance to HIV-1 infection in humans; the ancestral (G) allele of rs2074560 protects from HIV-1 infection with a recessive effect. PMID: 24930137
    10. The high prevalence of MxB-resistant mutations in the CypA-binding loop indicates the significant selective pressure of MxB on HIV-1 replication in vivo. PMID: 25571928
    11. MxB inhibits HIV-1 by interfering with minimally two steps of infection, nuclear entry and post-nuclear trafficking and/or integration, without destabilizing the inherent catalytic activity of viral preintegration complexes. PMID: 25348155
    12. HIV-seronegative women who use Depo-Provera have the highest levels of Mx2 expression, highlighting a possible mechanism for hormonal modulation of HIV resistance. PMID: 25562491
    13. The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized. PMID: 25363729
    14. MxB oligomerization is important for the ability of MxB to bind to the HIV-1 core proteins. PMID: 25568212
    15. A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2. PMID: 25673704
    16. structural analysis of assembly of human anti-HIV dynamin-like protein MxB/Mx2 PMID: 25446123
    17. MxB binding to the HIV-1 capsid. PMID: 25123063
    18. To identify protein domains of MX2 that specify HIV-1 inhibition. PMID: 24899177
    19. Through a combination of in vitro evolution and unbiased mutagenesis, authors further map the determinants of sensitivity to Mx2 and reveal that multiple capsid (CA) surfaces define sensitivity to Mx2. PMID: 24760893
    20. Taken together, it is concluded that human MxB protein inhibits HIV-1 DNA integration by a CypA-dependent mechanism. PMID: 24055605
    21. MX2 is therefore a cell-autonomous, anti-HIV-1 resistance factor whose purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS PMID: 24048477
    22. findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest that MX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes PMID: 24121441
    23. The MX2 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    24. the MX2 gene to be significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients PMID: 17702266
    25. The expression level of the MX2 gene tended to be downregulated in subjects carrying HLA-DQB1*0602, compared with that of the control subjects without this allele. PMID: 18517045

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding.
  • 蛋白家族:
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
  • 數據庫鏈接:

    HGNC: 7533

    OMIM: 147890

    KEGG: hsa:4600

    STRING: 9606.ENSP00000333657

    UniGene: Hs.926



主站蜘蛛池模板: 女人摸下面自熨视频在线播放| 97国产精东麻豆人妻电影| 午夜性开放午夜性爽爽| 丝袜老师高潮呻吟高潮| 伊人久久精品无码麻豆一区| 欧美性猛交aaaa片黑人| 日韩激情无码免费毛片| 午夜av亚洲一码二中文字幕青青| 日本乱码一区二区三区不卡| 粉嫩av国产一区二区三区| 人妻少妇被粗大爽9797pw| 国产在线高清理伦片a| 亚洲国内成人精品网| 国产猛烈高潮尖叫视频免费| 亚洲国精产品一二二线| 国产如狼似虎富婆找强壮黑人| 精品国产自在现线电影| 无码av一区二区三区无码| 羞羞视频在线观看| 97色成人综合网站| 好大好硬好爽免费视频| 国产成人无码18禁午夜福利p| 亚洲欧美日韩中文字幕在线一区| 中文字幕免费无码专区| 99久久99久久久精品齐齐| 中文字幕av无码不卡| 青青青国产在线视频在线观看| 精品人成视频免费国产| 久久天天躁夜夜躁狠狠85麻豆| 欲求不满邻居的爆乳在线播放| 99久久国产成人免费网站| 欧美 日韩 国产 亚洲 色| 艳妇臀荡乳欲伦交换在线播放| 欧美成人免费va影院高清| 中国真实偷乱视频| 亚洲不卡中文字幕无码| 国产99视频精品专区| 精品一区国产vr| 内射口爆少妇麻豆| 亚洲亚洲熟妇色l图片20p| 国产成人精品午夜福利不卡|