在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MVK Antibody

  • 中文名稱:
    MVK兔多克隆抗體
  • 貨號:
    CSB-PA003337
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using MVK Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MVK
  • 別名:
    FLJ96772 antibody; KIME_HUMAN antibody; LH receptor mRNA binding protein antibody; LRBP antibody; Mevalonate kinase 1 antibody; Mevalonate kinase antibody; Mevalonic aciduria antibody; MK antibody; mvk antibody; MVLK antibody; POROK3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Monkey
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human MVK.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
  • 基因功能參考文獻:
    1. The findings suggest that the MVK rs2287218 SNP is likely to increase the risk of CHD and IS by decreasing serum HDL-C levels in our study populations. PMID: 30101835
    2. Case Report: homozygous missense p.Cys161Arg in MVK was identified in family members with familial Mediterranean fever. PMID: 29148404
    3. Mevalonate kinase deficiency (MKD) can be associated with retinitis pigmentosa (RP) and early onset cataract. Most MKD patients developing RP carry the (p.Ala334Thr) mutation. PMID: 28095071
    4. In a cohort of mevalonate kinase deficiency patients, ninety-six (84%) of the patients harbored at least 1 p.V377I mutation, 14 (12%) of which were homozygous. The second most frequent mutation was p.I268T, occurring in 29 (25%) of the patients. None of them were p.I268T homozygous. A p.C152Y mutation was found in 1 patient. PMID: 27213830
    5. These findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of coronary heart disease by altering plasma HDL-C levels in Han Chinese. PMID: 27716295
    6. this study extends the mutation spectrum of MVK; MVK protein stability and correct folding might be the molecular mechanism causing disseminated superficial actinic porokeratosis PMID: 26794421
    7. Wild-type MK and the variant V261A, which is associated with HIDS, were recombinantly expressed in Escherichia coli. Enzyme activity was determined by formation of MVAP over time PMID: 25982894
    8. predictive analysis of mutations in MVK to predict disease severity PMID: 26420133
    9. study reports a novel mutation of the MVK gene in Chinese patients with disseminated superficial actinic porokeratosis (DSAP); result confirms the involvement of MVK gene in DSAP PMID: 25059119
    10. mutations are responsible for porokeratosis of Mibelli development in Chinese families PMID: 24781643
    11. results from this 4 generation family imply a causal relationship between MVK and perokeratosis. PMID: 25053464
    12. Results suggest that the effects of MVK mutations in Behcet's disease could be an additional genetic susceptibility factor for the patients with neurological involvement. PMID: 24411001
    13. The testing for the Hyper IgD Syndrome was positive for the pV377I/c.1129 G>A heterozygosity in a patient with periodic fever. PMID: 24708999
    14. Report a novel missense mutation in mevalonate kinase responsible for disseminated superficial actinic porokeratosis. PMID: 24551296
    15. study reportstwo novel mutations of the MVK gene in Chinese patients with disseminated superficial actinic porokeratosis PMID: 24008101
    16. These results suggest that hCG-induced down-regulation of LHR mRNA expression is mediated by activation of cAMP/PKA/ERK pathways to increase miR-122 expression, which then increases LRBP expression through the activation of SREBPs. PMID: 24064360
    17. Results identify a novel frameshift mutation in this gene implicated in disseminated superficial actinic porokeratosis in 4 Chinese families PMID: 23834120
    18. In the current article, we add another phenotype to the spectrum of diverging disorders associated with mutations in MVK. PMID: 24084495
    19. Novel mutations of MVK gene in Japanese family members affected with hyperimmunoglobulinemia D and periodic fever syndrome. This is the first case in which exon skipping mutation of the MVK gene has been certainly identified at the genomic DNA level. PMID: 22159817
    20. hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) patients carried 11 different MVK mutations mostly in compound heterozygosity; the most frequent mutation was p.Val377Ile; in Germany, the incidence of HIDS is very low PMID: 22038276
    21. MVK has a role in regulating calcium-induced keratinocyte differentiation and could protect keratinocytes from apoptosis induced by type A ultraviolet radiation. PMID: 22983302
    22. This atypical presentation of MA suggests that it should be included in the differential diagnosis of unclassified patients with psychomotor retardation, failure to thrive or ataxia, even in the absence of febrile episodes. PMID: 22271696
    23. The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency. PMID: 21430599
    24. Significant liver disease in a patient with Y116H mutation in the MVK gene. PMID: 21548022
    25. data show that LH-regulated ERK1/2 signaling is required for the LRBP-mediated down-regulation of LHR mRNA PMID: 21147848
    26. Results support that deleterious copy number alterations in MVK, NLRP3 and TNFRSF1A are rare or absent from the mutational spectrum of hereditary recurrent fevers. PMID: 21124859
    27. Report mevalonate kinase deficiency compromized fiberoblast geranylgeranylation of RhoA and Rac1. PMID: 20814828
    28. These data suggest MMAB is the most likely gene influencing high-density lipoprotein-cholesterol levels at MMAB-MVK locus. PMID: 20159775
    29. A novel missense mutation in mevalonate kinase (Tyr116His) is associated with mevalonate kinase deficiency and dyserythropoietic anemia. PMID: 20194276
    30. Mutations of MVK found in hyper-IgD and periodic fever syndrome patients affect the stability and/or maturation of MVK in vitro in a temperature-sensitive manner and may explain the chain of events leading to episodic inflammation and fever. PMID: 12444096
    31. Isoprenoid and cholesterol biosynthesis still occurs in cells from mevalonate kinase-deficient patients. PMID: 12477733
    32. Carrier frequency of 1:65 overestimates disease frequency, probably due to a reduced penetrance of V377I homozygosity. PMID: 12634869
    33. The subcellular localisation of human mevalonate kinase (MK) use a variety of biochemical and microscopical techniques. PMID: 14730012
    34. LH receptor mRNA-binding protein (LRBP) is a a novel trans-factor for luteinizing hormone receptor mRNA from ovary. PMID: 14749336
    35. Mevalonic aciduria, with psychomotor retardation, cerebellar ataxia, recurrent fever, and death in early childhood, and hyper-immunoglobulin D syndrome, with recurrent fever attacks without neurologic symptoms, are caused by mevalonate kinase deficiency PMID: 15037710
    36. Mutations in the coding region of the MVK gene were detected in 6 hyperimmunoglobulinemia D patients, and the most common mutation was V377I. PMID: 15188372
    37. Several hydrophobic amino acid side chains are positioned near the polyisoprenoid chain of FSP & their functional significance has been evaluated in mutagenesis experiments with human MK, which exhibits highest reported sensitivity to feedback inhibition. PMID: 18302342
    38. an intact active site of MVK is required for its binding to rat LHR mRNA and for its translational suppressor function PMID: 18494797
    39. homozygosity for the mutation of the MVK gene has been reported in an Asian patient, and indicated a need for differentiation. PMID: 18941711
    40. For the SNPs KCTD10_i5642G-->C and MVK_S52NG-->A, homozygotes for the major alleles (G) had lower HDL-cholesterol concentrations than did carriers of the minor alleles (P = 0.005 and P = 0.019, respectively). PMID: 19605566

    顯示更多

    收起更多

  • 相關疾病:
    Mevalonic aciduria (MEVA); Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); Porokeratosis 3, multiple types (POROK3)
  • 亞細胞定位:
    Cytoplasm. Peroxisome.
  • 蛋白家族:
    GHMP kinase family, Mevalonate kinase subfamily
  • 數據庫鏈接:

    HGNC: 7530

    OMIM: 175900

    KEGG: hsa:4598

    STRING: 9606.ENSP00000228510

    UniGene: Hs.130607



主站蜘蛛池模板: 久久亚洲精品成人av| 成人无遮羞视频在线观看| 精品国产乱码久久久久久婷婷| 国产精品一区二区在线蜜芽tv| 亚洲国产中文在线二区三区免| 亚洲国产精品va在线观看麻豆| 9420免费高清在线观看视频| 无码人妻av一区二区三区蜜臀| 国产日韩在线观看不卡顿| 国产在线精品一区二区夜色| 精品人妻伦一二三区久久| 一卡二卡3卡四卡网站精品| 亚洲制服丝中文字幕| 九九九国产精品成人免费视频| 国内精品久久毛片一区二区| 久久午夜福利电影| 少妇极品熟妇人妻| 欧美性黑人极品hd另类| 天天躁日日躁狠狠躁人妻| 无码国产精品成人| 邻居少妇张开腿让我爽了在线观看| 黑人糟蹋人妻hd中文字幕| 亚洲高清有码中文字| 人人妻人人澡人人爽偷拍台湾| 1000部夫妻午夜免费| 亚洲精品动漫免费二区| 狠狠色色综合站| 亚洲熟女乱色一区二区三区| 国产精成人品日日拍夜夜| 日韩人妻潮喷中文在线视频| 国产乱子伦视频在线播放| 蜜桃av抽搐高潮一区二区| 久久国产色av| 久久天天躁夜夜躁狠狠躁2014| 日本无卡码高清免费v| 又黄又爽的60分钟视频| 老熟妇仑乱一区二区视頻| av网站免费线看精品| 国产午睡沙发被弄醒完整版| 免费网站看sm调教视频| 一本本月无码-|