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MTTP Antibody

  • 中文名稱:
    MTTP兔多克隆抗體
  • 貨號:
    CSB-PA015209KA01HU
  • 規格:
    ¥2640
  • 圖片:
    • Western blot analysis of extracts of 293 cell lines, using MTTP antibody.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MTTP
  • 別名:
    ABL antibody; Microsomal triglyceride transfer protein (large polypeptide 88kDa) antibody; Microsomal triglyceride transfer protein 88kD antibody; Microsomal triglyceride transfer protein antibody; Microsomal triglyceride transfer protein large subunit antibody; MTP antibody; MTP large subunit antibody; MTP_HUMAN antibody; MTTP antibody; Transfer RNA, mitochondrial, proline antibody; tRNA-Pro, mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Recombinant protein of Human MTTP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins.
  • 基因功能參考文獻:
    1. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease PMID: 29540175
    2. Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease. PMID: 28950858
    3. The authors conclude that alternate splicing plays a key role in regulating cellular MTP levels by introducing distinct promoter regions and unique 5'-UTRs, which contain elements that alter translation efficiency, enabling the cell to optimize MTP activity. PMID: 27256115
    4. these data reveal clear cellular defects in induced pluripotent stem cells-derived hepatocytes and cardiomyocytes lacking MTTP activity, including a cardiomyocyte-specific regulated stress response to elevated lipids. PMID: 28514664
    5. two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL) patients, are reported. PMID: 27487388
    6. results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD PMID: 28953935
    7. Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB but not of truncated APOB. (APOB = apolipoprotein B; MTTP = microsomal triglyceride transfer protein) PMID: 28702990
    8. In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes. PMID: 28356060
    9. High expression of MTTP is associated with high carotid intima-media thickness. PMID: 27841945
    10. Its gene mutations are associated with abetalipoproteinemia, developmental delay and hepatic steatosis. PMID: 27160094
    11. MTP Gene Variants are associated with Homozygous Familial Hypercholesterolemia. PMID: 27170061
    12. the N-terminal domain of MTP is important for its lipid transfer activity PMID: 26224785
    13. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression. PMID: 25921304
    14. Results present evidence that MTTP polymorphisms could modulate the lipid homeostasis to determine the serum lipids and increase risk of non-alcoholic fatty liver disease. PMID: 26458397
    15. Findings from meta-analysis indicate that the MTP -493G/T polymorphism may contribute to the development of non-alcoholic fatty liver disease. Thus, the MTP -493G/T polymorphism may be a biomarker for the early detection of the disease. PMID: 25501226
    16. Homozygous MTTP mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia. PMID: 24842304
    17. MTTP SNPs (GG, GT, TT) and alleles (G, T) in the chronic hepatitis C (genotype 4) patients versus the uninfected controls were 70%, 21%, 9% & 80.5%, 19.5% versus 10%, 87.5%, 2.5% & 53.8%, 46.3%, respectively (p=0.0001). PMID: 25287167
    18. The MTP-493G/T polymorphism modulates postprandial apoB48 and apoB100 of triglyceride-rich lipoproteins in familial combined hyperlipidemia PMID: 24378322
    19. Case Reports: novel mutation in MTTP gene responsible for abetalipoproteinemia in Tunisian families. PMID: 23556456
    20. Report of two new mutations of MTTP, a nonsense mutation c.2313T > A leading to a truncated protein (p.Y771X) and a splice mutation IVS 9 + 2T > G, in abetalipoproteinemia PMID: 24139731
    21. MTTP genetic polymorphisms influence the susceptibility to developing NAFLD in the Han Chinese population. PMID: 23738963
    22. Meta-analysis results revealed that MTP -493G>T polymorphism was strongly correlated with an increased risk of nonalcoholic fatty liver disease. [Meta-analysis] PMID: 24588800
    23. The MTTP rs1800591 T allele could be a risk factor for metabolic syndrome in patients under atypical antipsychotic medication PMID: 23609384
    24. ABL is associated with the absence of both triglyceride and phospholipid transfer activities in MTP. PMID: 23475612
    25. MTP inhibition increased transcription of the GPT/GOT1 genes through up-regulation of the IRE1alpha/cJun pathway leading to increased synthesis and release of ALT1/AST1 PMID: 23532846
    26. MTP -493G/T polymorphism may play an important role in fashioning the serum lipid profiles of Bama populations, despite no direct association between MTP -493G/T and longevity was detected. PMID: 23273182
    27. An interaction between MTTP -164T > C functional polymorphism with total cholesterol levels and risk of cardiovascular disease. PMID: 23356586
    28. The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients PMID: 22147193
    29. MTTP mutations found in Tunisian children with chylomicron retention disease and abetalipoproteinemia were shown to disrupt mRNA splicing leading to premature termination codons . PMID: 23043934
    30. MTTP gene genotype is significantly overrepresented in centenarians and their offspring. PMID: 22496539
    31. two new mutations in MTTP in patients with abetalipoproteinemia PMID: 22150066
    32. a novel mechanism of MTP repression that involves binding of NR2F1 to the DR1 element and recruitment of corepressors PMID: 22357705
    33. nonalcoholic steatohepatitis(NASH)patients had higher incidence of MTP G/G genotype compared to controls; NASH patients also had a 100% prevalence of MnSOD T/T genotype; certain genotypes in MTP and MnSOD are more prevalent among obese children with NASH PMID: 21727734
    34. two mutations lead to abnormal truncated MTTP proteins, incapable of binding protein disulfide isomerase and responsible for the loss of function of MTTP in two children with a severe form of abetalipoproteinemia. PMID: 21394827
    35. the single nucleotide polymorphism (SNP) -129C/T (rs17883901) in glutamate-cysteine ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873) and Q95H (rs61733139) in microsomal triglyceride transfer protein (MTTP) in nonalcoholic fatty liver disease PMID: 21438662
    36. The MTP gene analysis by direct sequencing revealed a novel homozygous mutation (c.1586 A > G-H529R) in abetalipoproteinemia PMID: 21502686
    37. these results suggest that changes in MTP protein expression are not responsible for insulin-mediated suppression of apo B-containing lipoprotein secretion by the liver. PMID: 21316344
    38. we report here for the first time that MTP-493G/T polymorphism is associated with pancreatic beta-cell dysfunction, as assessed by two independent and validated methods, in NASH and healthy controls. PMID: 19733470
    39. MTP deficiency was associated with increased proteasomal degradation of group 1 CD1 molecules in human abetalipoproteinemia. PMID: 20592474
    40. MTTP-I128T polymorphism is associated with central obesity, elevated liver enzymes, and alcoholic fatty liver disease. PMID: 19262398
    41. Polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes may be associated with non-alcoholic liver disease progression. PMID: 19817962
    42. Transcriptional and posttranscriptional mechanisms involving NR2F1 and IRE1beta ensure low microsomal triglyceride transfer protein expression in undifferentiated intestinal cells and avoid apolipoprotein B lipoprotein biosynthesis. PMID: 20007910
    43. carriers of the minor -164C allele have lower expression of MTTP in the heart, mediated at least partly by the transcription factor CCAAT/enhancer binding protein. Reduced concentration of MTTP in the myocardium may contribute to ischemic heart disease PMID: 19546343
    44. MTP can function in both rough and smooth regions of endoplasmic reticulum in human hepatoma cells. PMID: 12020640
    45. Increased MTP gene expression and apoB mRNA levels are found in ventricular myocytes of patients undergoing coronary artery bypass surgery. PMID: 12231571
    46. insulin inhibits MTP gene transcription through MAPK(erk) cascade but not through the PI 3-kinase pathway PMID: 12716735
    47. MTP genotye -493G/T polymorphism only has a minor effect on LDL cholesterol subfraction pattern in chinese patient. PMID: 12818411
    48. genetic association study identified a haplotype marker within microsomal transfer protein as a modifier of human lifespan PMID: 14615589
    49. Microsomal triglyceride transfer protein (MTP) has been associated with ABL. PMID: 14741197
    50. functional polymorphisms in MTP and MnSOD may be involved in determining susceptibility of non-alcoholic steatohepatitis PMID: 15094225

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  • 相關疾病:
    Abetalipoproteinemia (ABL)
  • 亞細胞定位:
    Endoplasmic reticulum. Golgi apparatus.
  • 組織特異性:
    Liver and small intestine. Also found in ovary, testis and kidney.
  • 數據庫鏈接:

    HGNC: 7467

    OMIM: 157147

    KEGG: hsa:4547

    STRING: 9606.ENSP00000265517

    UniGene: Hs.195799



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