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  4. MTMR14 Antibody

MTMR14 Antibody

  • 中文名稱：
    MTMR14兔多克隆抗體
  • 貨號：
    CSB-PA847682ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA847682ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA847682ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MTMR14 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C3orf29 antibody; Egg derived tyrosine phosphatase homolog antibody; FLJ11546 antibody; FLJ22405 antibody; FLJ46453 antibody; FLJ90311 antibody; HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody; hEDTP antibody; hJumpy antibody; jumpy antibody; MTMR 14 antibody; MTMR14 antibody; MTMRE_HUMAN antibody; Myotubularin related protein 14 antibody; Myotubularin-related protein 14 antibody; NS5ATP4ABP1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Myotubularin-related protein 14 protein (1-280AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
  • 基因功能參考文獻：
    1. This study provides the first in vivo evidence for a role of myotubularins, and in particular MTMR14, in the regulation of autophagy. PMID: 20595810
    2. The authors uncovered a key negative regulatory role in autophagy of a phosphatidylinositol 3-phosphate (PI3P) phosphatase Jumpy (MTMR14). PMID: 19590496
    3. Study identified a novel phosphoinositide phosphatase, JUMPY in sporadic cases of centronuclear myopathy; two missense variants that affect the enzymatic function were found PMID: 17008356
    4. C3orf29 encodes hJUMPY, a phosphoinositide 3-phosphate phosphatase that acts on PtdIns3P and PtdIns(3,5)P2. A missense mutation disrupts the catalytic activity in a patient with centronuclear myopathy. PMID: 17008356
  • 相關疾病：
    Myopathy, centronuclear, 1 (CNM1)
  • 亞細胞定位：
    Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 組織特異性：
    Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 26190

    OMIM: 160150

    KEGG: hsa:64419

    STRING: 9606.ENSP00000296003

    UniGene: Hs.475382



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