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  4. MTMR12 Antibody, Biotin conjugated

MTMR12 Antibody, Biotin conjugated

  • 中文名稱：
    MTMR12兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA880158LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MTMR12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MTMR12
  • 別名：
    MTMR12 antibody; KIAA1682 antibody; PIP3AP antibody; Myotubularin-related protein 12 antibody; Inactive phosphatidylinositol 3-phosphatase 12 antibody; Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit antibody; 3-PAP antibody; 3-phosphatase adapter protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Myotubularin-related protein 12 protein (188-318AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.
  • 基因功能參考文獻：
    1. Analysis of human XLMTM patient myotubes showed that mutations that disrupt the interaction between myotubularin and MTMR12 proteins result in reduction of both myotubularin and MTMR12 PMID: 23818870
    2. This study does not support the association of PDZD2, GOLPH3, and MTMR12 genes with schizophrenia. PMID: 21451436
    3. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. PMID: 12847286
  • 亞細胞定位：
    Cytoplasm. Sarcoplasmic reticulum. Cytoplasm, myofibril, sarcomere.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 組織特異性：
    Expressed in skeletal muscles (at protein level). Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung.
  • 數據庫鏈接：

    HGNC: 18191

    OMIM: 606501

    KEGG: hsa:54545

    STRING: 9606.ENSP00000371577

    UniGene: Hs.481836



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