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MT1F Antibody, Biotin conjugated

  • 中文名稱:
    MT1F兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA17409D0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MT1F Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MT1F
  • 別名:
    MT1F antibody; PRO0376 antibody; Metallothionein-1F antibody; MT-1F antibody; Metallothionein-IF antibody; MT-IF antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Metallothionein-1F protein (1-61AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能參考文獻:
    1. we found that metallothionein expression induced by Cd occurred much later, with the expression seen at least 12h or more after the Nrf2-dependent immediate responses were almost completed. PMID: 24440467
    2. Metallothionein may have a role in the control of apoptosis in pleomorphic adenoma. PMID: 23332881
    3. Aortic protection in diabetes by zinc supplementation is associated with upregulation of both metallothionein and Nrf2 expression. PMID: 23536959
    4. findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type; upregulated MT-1F expression associated with larger primary tumor size and higher grade of malignanacy PMID: 23064051
    5. MT1F is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by loss of heterozygosity in colon cancer tissue PMID: 22426038
    6. This study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression. PMID: 21820154
    7. Studies provide the mechanistic properties of metal binding for metallothionein metallation. PMID: 21409206
    8. MT-1 rs8052394 A allele is associated with oral squamous cell carcinoma. PMID: 21128001
    9. In the liver cancer tissue, MT1F shows down-regulated expression that supports the inhibited function of MT1F in cancer growth PMID: 15369632
    10. Knockdown of MT1F gene increased particular matter(2.5)-induced H2O2 release in alveolar macrophages. PMID: 19251948

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  • 蛋白家族:
    Metallothionein superfamily, Type 1 family
  • 數據庫鏈接:

    HGNC: 7398

    OMIM: 156352

    KEGG: hsa:4494

    STRING: 9606.ENSP00000334872

    UniGene: Hs.513626



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