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  4. MT-CYB Antibody

MT-CYB Antibody

  • 中文名稱：
    MT-CYB兔多克隆抗體
  • 貨號：
    CSB-PA581286
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA581286(MT-CYB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA581286(MT-CYB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    COB antibody; Complex III subunit 3 antibody; Complex III subunit III antibody; CYB_HUMAN antibody; CYTB antibody; Cytochrome b antibody; Cytochrome b c1 complex subunit 3 antibody; Cytochrome b-c1 complex subunit 3 antibody; Mitochondrially encoded cytochrome b antibody; MT-CYB antibody; MTCYB antibody; Ubiquinol cytochrome c reductase complex cytochrome b subunit antibody; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MT-CYB
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
  • 基因功能參考文獻：
    1. The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis PMID: 29368910
    2. The effects of mutation in mitochondrially encoded cytochrome b are reviewed. PMID: 28132468
    3. Mitochondrial mutation m.15804T>C in the mtCYB gene in a family with fibromyalgia is associated with NLRP3-inflammasome activation. PMID: 26566881
    4. These results indicate that miR-151a-5p may participate in the regulation of cellular respiration and ATP production through targeting Cytb. PMID: 26626315
    5. The polymorphisms of CYTB as a very useful DNA marker were significantly different between different geographical Uyghur PMID: 24103151
    6. Significant elevation of ERalpha and MTCYB transcript levels in premenopausal leiomyomas and its association with ERalpha, -397 CC genotype suggests the mitochondrial-mediated role of estrogen as the promoter of leiomyoma tumorigenesis. PMID: 21506659
    7. mitocryptide-2 (MCT-2) and its human homolog hMCT-2 are cryptides that activate neutrophils PMID: 19342687
    8. The other proband had a non-synonymous G15221A mutation in the cytochrome b gene. PMID: 12031626
    9. In a mitochondrial myopathy patient, a novel stop-codon mutation (G15761A) was found in the mitochondrial DNA (mtDNA)-encoded cytochrome b gene, resulting in loss of the last 41 amino acids of the protein and complex III deficiency PMID: 12686403
    10. clinical/phenotypic variability of the G15498A mutation in mitochondrial DNA PMID: 14735157
    11. biochemical and molecular genetic studies of a patient with both muscle and brain involvement and a severe reduction in the activities of both complexes I and III in skeletal muscle due to a novel mutation in the MTCYB gene PMID: 16008558
    12. caspase 8-dependent cleavage of mitochondrial Cyt b and translocation of its C-terminal half into the cytoplasm occurred during FAS-induced apoptosis in both chicken and human cells PMID: 18796602
    13. CytbI7T has a role in longevity related to caloric restriction PMID: 19503808
    14. The m.15635T>C transition (S297P) was carried by a newborn who presented with a polyvisceral failure. PMID: 19563916
    15. cytochrome B gene mutation induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. PMID: 19569044

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  • 相關疾病：
    Cardiomyopathy, infantile histiocytoid (CMIH); Leber hereditary optic neuropathy (LHON)
  • 亞細胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cytochrome b family
  • 數據庫鏈接：

    HGNC: 7427

    OMIM: 500000

    KEGG: hsa:4519

    STRING: 9606.ENSP00000354554



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