在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MT-CO2 Antibody, HRP conjugated

  • 中文名稱:
    MT-CO2兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA015073LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MT-CO2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    MT-CO2; COII; COX2; COXII; MTCO2; Cytochrome c oxidase subunit 2; Cytochrome c oxidase polypeptide II
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Cytochrome c oxidase subunit 2 protein (83-227AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能參考文獻(xiàn):
    1. Study shows that higher COX-2 and ALOX5 expression in colorectal cancer (CRC) tissues was correlated with poorer prognosis in patients with CRC. Also, MiR-216a-3p was shown to directly bind to there 3'-UTR and inversely regulates their protein levels modulating CRC cell proliferation. PMID: 28786533
    2. Data suggest that mutations in MT-CO2 and MT-ND5 can be involved in MIDD (maternally inherited diabetes and deafness); a Tunisian family (mother, daughter, son) with clinical features of MIDD associated with retinopathy exhibit mutations in MT-CO2 (m.8241T>G - p. F219C) and MT-ND5 (m.13276G>A - p. M314V); these two mutations could explain retinopathy in some family members. (MT-ND5 = NADH dehydrogenase subunit 5) PMID: 27422531
    3. Results demonstrates that the presence of high levels of COX-2 is associated with poor prognosis for breast cancer patients and predicts bigger tumor size and lymph node metastasis. [metastasis] PMID: 27999206
    4. results demonstrated that XRCC5 promoted colon cancer growth by cooperating with p300 to regulate COX-2 expression, and suggested that the XRCC5/p300/COX-2 signaling pathway was a potential target in the treatment of colon cancers PMID: 29049411
    5. inhibitory effects of 17-AAG on PGE2 levels in HT-29 colorectal cancer cells were mediated through modulating COX-2 and 15-PGDH expression. PMID: 27075590
    6. The sequencing analysis revealed the presence of 17 variants, mostly causing non-synonymous changes in conserved amino acid residues, typically distributed in the MT-CO2 gene of MUTYH-associated polyposis patients (P < 0.0001), who frequently carried the hot spot m.7763G>A variant. PMID: 26138249
    7. Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2. PMID: 26160915
    8. Mutational analysis show a novel MTCO2 mutation 8249G>A pathogenic variation in Tunisian patients with mitochondrial myopathy. PMID: 23841600
    9. We also detected in 4 asthenospermic patients a double novels mutations, the first was found in COXII gene (m.8021 G/A) that was absent in normospermic infertile men. PMID: 24931671
    10. The presence of a non-synonymous variation in the COII strongly correlated with poor survival in patients with cytogenetically normal acute myeloid leukemia. PMID: 23826975
    11. Protein modeling revealed loss of function mutations of ND6 and COX-II proteins in malignant vs benign tumors PMID: 24061460
    12. COX-2 expression played an essential role in the proliferation and metastasis of tongue cancer. PMID: 21069476
    13. Novel COII mutations responsible for maternally inherited nonsyndromic hearing loss PMID: 22241583
    14. The apoptotic index of pulmonary vascular endothelial cells was negatively correlated with COXII expression in patients with chronic obstructive pulmonary disease. PMID: 21092633
    15. This protein has been found differentially expressed in thalami from patients with schizophrenia. PMID: 20471030
    16. COX-II is induced in HIV infected apoptotic T-cells. PMID: 19771519
    17. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function. PMID: 12031622
    18. the expression of mitochondria-encoded COXII is HRG-responsive. The levels of ErbB2 expression are decisive for the diverse biological activities of HRG. PMID: 12115729
    19. frequency of occurrence of mtDNA with the COII/tRNA(Lys) intergenic 9-bp deletion polymorphism in patients with myoclonic epilepsy with ragged-red fibers or mitochondrial encephalomyopathy syndrome is higher than that of healthy subjects PMID: 15965049
    20. Mutations in mtDNA-encoded cytochrome c oxidase subunit II genes causing isolated myopathy or severe encephalomyopathy. PMID: 16288875
    21. DNA hypermethylation of the COX-2 gene may be a potential prognostic marker in early stage cervical cancer. PMID: 17578348
    22. a fraction of Sco1 physically associates with the cytochrome c oxidase complex in human muscle mitochondria, suggesting a possible direct relationship between CcO and the regulation of cellular copper homeostasis PMID: 19295170
    23. SCO2 acts upstream of SCO1, and that it is indispensable for CO II synthesis. PMID: 19336478
    24. CoxII can be phosphorylated by EGFR and c-Src, and EGF stimulation reduces Cox activity and cellular ATP, an event that is dependent in large part on EGFR localized to the mitochondria. PMID: 19840943
    25. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 12732844

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mitochondrial complex IV deficiency (MT-C4D)
  • 亞細(xì)胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cytochrome c oxidase subunit 2 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7421

    OMIM: 220110

    KEGG: hsa:4513

    STRING: 9606.ENSP00000354876



主站蜘蛛池模板: 日韩人妻无码精品一专区| 欧洲乱码伦视频免费| 国模吧无码一区二区三区| 五月花成人网| 久久精品国产精品青草| 亚洲综合色婷婷六月丁香宅男大增| 久久精品成人免费观看97| 99国产欧美另娄久久久精品| av午夜福利一片免费看久久| 国产乱人伦app精品久久| 久久久www成人免费精品| 曰本一道本久久88不卡| 最新无码a∨在线观看| 天天狠天天透天干天天怕∴| 久久久久夜夜夜精品国产| 国产欧美二区综合| av无码动漫一区二区三区精品| 好爽...又高潮了毛片| 无码人妻av免费一区二区三区| 成人内射国产免费观看| 午夜影视啪啪免费体验区入口| 国内精品乱码卡一卡2卡麻豆| 午夜三级a三级三点在线观看| 亚洲 高清 成人 动漫| 欧美午夜精品久久久久久浪潮| 又湿又紧又大又爽又a视频| 无遮18禁在线永久免费观看挡| 久久久久久久97| 亚洲精品tv久久久久久久久久| 亚洲成av人片天堂网久久| 亚洲伦无码中文字幕另类| 国产一码二码三码区别| 玩弄人妻少妇500系列视频| 国产模特嫩模私拍视频在线| 国产成人综合久久免费| 亚洲精品无码一区二区| 欧美日韩不卡视频合集| 欧美日韩在手机线旡码可下载 | 久久综合丝袜日本网| 大伊香蕉在线精品视频75| 免费国产裸体美女视频全黄|