在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MSRB3 Antibody

  • 中文名稱:
    MSRB3兔多克隆抗體
  • 貨號:
    CSB-PA810290DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: MSRB3 antibody at 4.61 μg/ml
      Lane 1: Mouse large intestine tissue
      Lane 2: Mouse lung tissue
      Lane 3: Mouse gonadal tissue
      Lane 4: Mouse heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 21 kDa
      Observed band size: 21 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MSRB3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MSRB3
  • 別名:
    Deafness, Autosomal Recessive 74 antibody; DFNB74 antibody; FLJ36866 antibody; Methionine R sulfoxide reductase B mitochondrial antibody; Methionine sulfoxide reductase B3 antibody; Methionine-R-sulfoxide reductase B3 antibody; MsrB3 antibody; MSRB3_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Methionine-R-sulfoxide reductase B3 protein (1-185AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
  • 基因功能參考文獻:
    1. we characterise the mammalian enzyme Msr B3. There are two splice variants of this enzyme that differ only in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria PMID: 29420254
    2. This characterization of GWAS-implicated MSRB3 protein expression in human hippocampus suggests that patterns of neuronal and vascular MsrB3 protein expression reflect or underlie pathology associated with Alzheimer disease. PMID: 28777754
    3. Oncogene induction in differentiated cells induces massive DNA damage, mammary stem cells are resistant, owing to a preemptive program driven by ZEB1 and MSRB3. The prevention of oncogene-induced DNA damage precludes induction of the oncosuppressive p53-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation. PMID: 28394329
    4. The data suggest that MsrB3 attenuates HO-1 induction by inhibiting reactive oxygen species production, endoplasmic reticulum stress, and Nrf2 activation. PMID: 27059143
    5. MsrB3 plays an important role in cancer cell survival through the modulation of the intrinsic apoptosis pathway. PMID: 28007593
    6. Taken together, our results suggest that MsrB3 plays a critical role in cancer cell apoptosis through the modulation of ER stress status. PMID: 28389299
    7. MsrB3 deficiency activates the cell cycle inhibitors p21 and p27. PMID: 24583268
    8. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. PMID: 22422452
    9. these data provide evidence that the ER-type of MsrB3 plays an important role in protection against ER stress, suggesting that MsrB3 may be involved in the regulation of ER homeostasis. PMID: 22405767
    10. Taken together, these data provide evidence that the ER type of MsrB, MsrB3A, plays an important role in protection mechanisms against oxidative, cold and heat stresses and, moreover, in the regulation of fruit fly aging. PMID: 22310715
    11. Results identified an antimicrobial peptide from the human methionine sulfoxide reductase B3 protein. PMID: 22027001
    12. an in vitro assay revealed that p.Cys89Gly completely abolished MSRB3 enzymatic activity and that p.Arg19X is a null allele for MSRB3 mitochondrial isoforms, indicating that DFNB74 deafness might be a mitochondrial disease limited to the inner ear. PMID: 21185009
    13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195514

    顯示更多

    收起更多

  • 相關疾病:
    Deafness, autosomal recessive, 74 (DFNB74)
  • 亞細胞定位:
    [Isoform 1]: Endoplasmic reticulum.; [Isoform 2]: Mitochondrion.
  • 蛋白家族:
    MsrB Met sulfoxide reductase family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 27375

    OMIM: 613718

    KEGG: hsa:253827

    STRING: 9606.ENSP00000347324

    UniGene: Hs.339024



主站蜘蛛池模板: 99久久99久久久精品齐齐| 爆乳高潮喷水无码正在播放| 精品一区二区三区在线播放视频| 国产色婷婷亚洲99精品小说| 亚洲午夜久久久久久久久电影网| 国产精品色情国产三级在| 免费啪视频在线观看视频日本| 人人爽人人爽人人爽| 色一情一乱一伦| 区二区三区玖玖玖| 国产欧美日韩亚洲精品专区| 特黄做受又粗又大又硬老头| 中日av乱码一区二区三区乱码| 亚洲一区二区三区在线播放无码| 久久久噜噜噜久久熟女色| 伊人色合天天久久综合网| 人妻少妇精品中文字幕av | 亚洲性猛交xxxx| 久久精品a亚洲国产v高清不卡| 无码吃奶揉捏奶头高潮视频| awww在线天堂bd资源在线| 风流少妇又紧又爽又丰满| 国产午夜福利片| 成人美女黄网站色大色费全看| 狠狠色丁香久久综合| 亚洲综合无码一区二区| 欲色影视天天一区二区三区色香欲| 日韩精品一卡2卡3卡4卡新区| 欧美精品videossex少妇| 日本乱妇乱子视频网站-百度| 2020国产精品永久在线| 天天爱天天做久久狼狼| 精品久久人人爽天天玩人人妻| 中文字幕无码毛片免费看| 西西艺术人像摄影| 久久久久免费看黄a片app| 自拍日韩亚洲一区在线| 一本天堂v无码亚洲道久久| 国产99视频精品免视看7| 欧美国产国产综合视频| 热99re久久精品天堂|