在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MSRB3 Antibody

  • 中文名稱:
    MSRB3兔多克隆抗體
  • 貨號:
    CSB-PA810290DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: MSRB3 antibody at 4.61 μg/ml
      Lane 1: Mouse large intestine tissue
      Lane 2: Mouse lung tissue
      Lane 3: Mouse gonadal tissue
      Lane 4: Mouse heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 21 kDa
      Observed band size: 21 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MSRB3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MSRB3
  • 別名:
    Deafness, Autosomal Recessive 74 antibody; DFNB74 antibody; FLJ36866 antibody; Methionine R sulfoxide reductase B mitochondrial antibody; Methionine sulfoxide reductase B3 antibody; Methionine-R-sulfoxide reductase B3 antibody; MsrB3 antibody; MSRB3_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Methionine-R-sulfoxide reductase B3 protein (1-185AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
  • 基因功能參考文獻:
    1. we characterise the mammalian enzyme Msr B3. There are two splice variants of this enzyme that differ only in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria PMID: 29420254
    2. This characterization of GWAS-implicated MSRB3 protein expression in human hippocampus suggests that patterns of neuronal and vascular MsrB3 protein expression reflect or underlie pathology associated with Alzheimer disease. PMID: 28777754
    3. Oncogene induction in differentiated cells induces massive DNA damage, mammary stem cells are resistant, owing to a preemptive program driven by ZEB1 and MSRB3. The prevention of oncogene-induced DNA damage precludes induction of the oncosuppressive p53-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation. PMID: 28394329
    4. The data suggest that MsrB3 attenuates HO-1 induction by inhibiting reactive oxygen species production, endoplasmic reticulum stress, and Nrf2 activation. PMID: 27059143
    5. MsrB3 plays an important role in cancer cell survival through the modulation of the intrinsic apoptosis pathway. PMID: 28007593
    6. Taken together, our results suggest that MsrB3 plays a critical role in cancer cell apoptosis through the modulation of ER stress status. PMID: 28389299
    7. MsrB3 deficiency activates the cell cycle inhibitors p21 and p27. PMID: 24583268
    8. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. PMID: 22422452
    9. these data provide evidence that the ER-type of MsrB3 plays an important role in protection against ER stress, suggesting that MsrB3 may be involved in the regulation of ER homeostasis. PMID: 22405767
    10. Taken together, these data provide evidence that the ER type of MsrB, MsrB3A, plays an important role in protection mechanisms against oxidative, cold and heat stresses and, moreover, in the regulation of fruit fly aging. PMID: 22310715
    11. Results identified an antimicrobial peptide from the human methionine sulfoxide reductase B3 protein. PMID: 22027001
    12. an in vitro assay revealed that p.Cys89Gly completely abolished MSRB3 enzymatic activity and that p.Arg19X is a null allele for MSRB3 mitochondrial isoforms, indicating that DFNB74 deafness might be a mitochondrial disease limited to the inner ear. PMID: 21185009
    13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195514

    顯示更多

    收起更多

  • 相關疾病:
    Deafness, autosomal recessive, 74 (DFNB74)
  • 亞細胞定位:
    [Isoform 1]: Endoplasmic reticulum.; [Isoform 2]: Mitochondrion.
  • 蛋白家族:
    MsrB Met sulfoxide reductase family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 27375

    OMIM: 613718

    KEGG: hsa:253827

    STRING: 9606.ENSP00000347324

    UniGene: Hs.339024



主站蜘蛛池模板: av在线亚洲欧洲日产一区二区| 国产农村妇女高潮大叫| 国产欧美成人一区二区a片| 欧美国产精品日韩在线| 日韩精品无码一区二区中文字幕| 欧美三级不卡在线播放| 国产69精品久久久久乱码| 久久久综合九色合综| 蜜臀av在线播放一区二区三区| 国内精品国产三级国产av| 中无码人妻丰满熟妇啪啪| 无码综合天天久久综合网| 久久亚洲精品无码观看不卡| 综合偷自拍亚洲乱中文字幕 | 亚洲日韩中文字幕无码一区| 亚洲精品久久久久久动漫器材一区 | 日本三级欧美三级人妇视频| 曰批免费视频播放免费| 极品少妇被后入内射视| 国产av成人精品播放| 人妻少妇无码精品专区| av人摸人人人澡人人超碰下载| 亚洲综合另类小说色区一| 久久亚洲a片com人成| 蜜臀av综合网| 99国产揄拍国产精品人妻| 亚洲人妻av伦理| 久久精品中文无码资源站| 久久99国产精品二区| 中文无码日韩欧| 久久久久噜噜噜亚洲熟女综合| 天天天天做夜夜夜夜做无码| 韩国 日本 亚洲 国产 不卡| 日本公妇乱偷中文字幕| 国产午夜福利100集发布| 亚洲综合熟女久久久40p| 国产成人精选在线观看不卡| 国产男女猛烈无遮挡免费网站| 日本熟妇色xxxxx日本免费看| 边吃奶边添下面好爽| 久久亚洲色www成人男男|