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  4. MSRB1 Antibody, Biotin conjugated

MSRB1 Antibody, Biotin conjugated

  • 中文名稱：
    MSRB1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA882163LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MSRB1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MSRB1
  • 別名：
    Annexin A2 like antibody; EC 1 8 4 antibody; HSPC 270 antibody; HSPC270 antibody; Methionine R sulfoxide reductase antibody; Methionine R sulfoxide reductase B1 antibody; Methionine sulfoxide reductase antibody; Methionine-R-sulfoxide reductase B1 antibody; MGC3344 antibody; MSRB 1 antibody; MsrB1 antibody; MSRB1_HUMAN antibody; OTTHUMP00000159418 antibody; Sel X antibody; Selenoprotein R antibody; Selenoprotein X 1 antibody; Selenoprotein X antibody; Selenoprotein X1 antibody; SELR antibody; SelX antibody; SEPX 1 antibody; sepx1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Methionine-R-sulfoxide reductase B1 protein (1-116AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
  • 基因功能參考文獻：
    1. In vivo, MsrB1 shRNAi can inhibit lung metastasis in metastasis model. In conclusion, MsrB1 regulates proliferation and invasion of u2os cells by affecting MAPK pathway and EMT, and MsrB1 gene may be a novel therapeutic target against tumors. PMID: 29395081
    2. FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide, a pathological protein of AD, which suggested a potential effect of SelR and Abeta with the aid of Clu. The interaction between SelR and Clu provides a novel avenue for further study on the mechanism of SelR in AD prevention. PMID: 23805218
    3. MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption. PMID: 24342607
    4. findings suggested that SelX played important roles in protecting LO2 cells against oxidative damage and reducing H2O2-induced apoptosis in liver cells. PMID: 26899321
    5. Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress PMID: 26875981
    6. Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. PMID: 23988788
    7. MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption PMID: 24342607
    8. MsrB1 plays important roles in protecting HLE cell mitochondria against oxidative damage and inhibits oxidative stress-induced apoptosis in diabetic cataracts by scavenging ROS. PMID: 23270945
    9. The results demonstrate that in human lens epithelial cells MsrB1 may play important roles in regulating redox balance and mitigating endoplasmic reticulum stress. PMID: 22713178
    10. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 21048031
    11. The neutrophils expressed the highest activity Msrs. Msrs are important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage. PMID: 17938273
    12. Strong candidate gene for schizophrenia; upregulated in lymphoblastoid cells of monozygotic twins. PMID: 18081029
    13. The studies in mouse show that MsrB is a selenoprotein that exhibits high specificity for reduction of the R forms of free and protein-bound methionine sulfoxide. PMID: 11779133

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    MsrB Met sulfoxide reductase family
  • 數據庫鏈接：

    HGNC: 14133

    OMIM: 606216

    KEGG: hsa:51734

    STRING: 9606.ENSP00000355084

    UniGene: Hs.655346



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