在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MSH4 Antibody

MSH4 Antibody

  • 中文名稱：
    MSH4兔多克隆抗體
  • 貨號：
    CSB-PA987494
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA987494(MSH4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA987494(MSH4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • 產品描述：

    The fusion protein of human MSH4 is used to immunized rabbits to generate the anti-MSH4 antibody. The resulting product is a polyclonal antibody and exists as an unconjugated IgG. It has undergone antigen affinity purification. And it can react with human and mouse samples. This MSH4 antibody has passed through the quality control via ELISA and IHC analyses. Its target protein MSH4 is a meiosis-specific homologue of the bacterial MutS mismatch repair protein that plays no role in mismatch correction and that is required for wild-type level of meiotic crossovers in budding yeast and nematode.

  • Uniprot No.：
  • 基因名：
    MSH4
  • 別名：
    hMSH4 antibody; MSH 4 antibody; MSH4 antibody; MSH4_HUMAN antibody; MutS homolog 4 (E. Coli) antibody; MutS homolog 4 antibody; MutS protein homolog 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human MSH4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
  • 基因功能參考文獻：
    1. Study describes the first MSH4 mutation associated with POI and increases the number of meiotic/DNA repair genes formally implicated as being responsible for this condition. PMID: 28541421
    2. inactivation of MSH4 in germ cells may have played a role in the acquisition of additional TP53 and LATS1 germline mutations in a Li-Fraumeni family PMID: 25041856
    3. hMSH4 interacts with HDAC3. PMID: 24145748
    4. Our current study has revealed a role for hMSH4 in the maintenance of genomic stability by suppressing NHEJ-mediated DSB repair. PMID: 23725059
    5. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages PMID: 21126912
    6. The different properties associated with these two hMSH5 variants underscore the potential functional diversity of the human hMSH5 gene. PMID: 15907804
    7. the GPS2 might function in concert with hMSH4-hMSH5 during the process of homologous recombination. PMID: 16122992
    8. A review of the properties and functional roles of MSH4. PMID: 17127347
    9. Dimerization of MSH4 and MSH5 facilitates their nuclear localization suggesting that dimerization may regulate the intracellular trafficking of these proteins. PMID: 17869244
    10. Data have identified the interaction region between the individual subunits of hMSH4-hMSH5 that are likely involved in clamp formation and show that each subunit of the heterodimer binds ATP. PMID: 17977839
    11. Data show that there is no association between MSH4 gene mutation and premature ovarian failure. PMID: 18166824

    顯示更多

    收起更多

  • 亞細胞定位：
    Chromosome.
  • 蛋白家族：
    DNA mismatch repair MutS family
  • 組織特異性：
    Testis and ovary specific.
  • 數據庫鏈接：

    HGNC: 7327

    OMIM: 602105

    KEGG: hsa:4438

    STRING: 9606.ENSP00000263187

    UniGene: Hs.216639



主站蜘蛛池模板： 性色av免费观看| 亚洲第一在线综合网站| 国产无遮挡又黄又爽高潮| 亚洲国产日韩a在线播放| 综合亚洲伊人午夜网| 国产av丝袜旗袍无码网站| 国产精品 无码专区| 亚洲欧洲无码av电影在线观看| 狠狠色狠狠色五月激情| 亚洲跨种族黑人xxxxx| 国产亚洲产品影市在线产品| 特黄大片又粗又大又暴| 精品无人乱码一区二区三区的特点| 精品第一国产综合精品蜜芽| 久九九久视频精品免费| 国产三级在线观看完整版| 久久777国产线看观看精品| 在线观看日本亚洲一区| 性av盈盈无码天堂| 亚洲一区二区av在线观看| 无码成人一区二区| 精品久久久噜噜噜久久久| 亚洲伊人成综合人影院青青青| 午夜福利不卡片在线机免费视频| 人妻av无码中文专区久久| 欧美黑人又粗又大又爽免费| 亚洲人成色4444在线观看| av高清无码 在线播放| 午夜性刺激在线视频免费| 夜夜爽日日澡人人添| 十八禁视频网站在线观看| 日韩 国产 变态另类 欧美| 骚虎成人免费99xx| 三上悠亚ssⅰn939无码播放| 蜜桃av色偷偷av老熟女| 日本无码人妻精品一区二区蜜桃| 国内精品免费网站牛牛| 成人午夜福利视频镇东影视| 久久99精品国产99久久6尤物| 少妇性荡欲视频| 国产精品无码天天爽视频|