在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MS4A2 Antibody, Biotin conjugated

  • 中文名稱:
    MS4A2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA015013LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MS4A2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    APY antibody; ATOPY antibody; Fc epsilon receptor I beta-chain antibody; Fc IgE receptor beta chain antibody; FCER1B antibody; FCERB_HUMAN antibody; FcERI antibody; High affinity immunoglobulin epsilon receptor subunit beta antibody; IgE Fc receptor subunit beta antibody; IGEL antibody; IGHER antibody; Membrane-spanning 4-domains subfamily A member 2 antibody; MS4A1 antibody; Ms4a2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human High affinity immunoglobulin epsilon receptor subunit beta protein (1-59AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
  • 基因功能參考文獻(xiàn):
    1. Using immunohistochemistry, we validated that MS4A2, the beta subunit of the IgE receptor expressed on mast cells, is a favorable prognostic indicator and show that MS4A2 gene expression is an independent prognostic marker for early-stage lung cancer patient survival. PMID: 28775209
    2. in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels. PMID: 26792385
    3. study found a difference in the frequencies of genotypes of FcvarepsilonRIbeta subunit int 2 in allergic rhinitis patients and controls. The FcvarepsilonRIbeta subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort PMID: 24981302
    4. MS4A2 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
    5. no association between gene polymorphism and chronic spontaneous urticaria in Kashmiri population PMID: 24953255
    6. FcepsilonRIbeta -109C/T and IFN-gamma 874T/A polymorphisms may be influencing factors for asthma in the Asian population PMID: 25530133
    7. The results explain how initial membrane interactions of clustered IgE-Fcepsilon RI complexes lead to downstream cellular responses. PMID: 25658351
    8. Data indicated that the MS4A2 gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians. PMID: 24495860
    9. Cytoplasmic FcepsilonRIbeta, which is not co-localized with FcepsilonRIalpha, may function as a negative regulator, as it can capture important signalling molecules such as Lyn. PMID: 24118172
    10. t-FcepsilonRIbeta mediates Ca2+ -dependent microtubule formation, which promotes degranulation and cytokine release. PMID: 23643722
    11. The interaction between Lyn and FcepsilonRIbeta is indispensable for FcepsilonRI-mediated human mast cell activation. PMID: 22845063
    12. Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis. PMID: 22150093
    13. Polymorphisms in the Fc epsilon R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways in asthmatic patients. PMID: 19288130
    14. No associations with total and specific IgE levels as well as allergic sensitization were seen for FCER1B and FCER1G PMID: 20028371
    15. Methylation levels at the AluSp repeat analysed in MS4A2 were inconsistent with classical imprinting mechanisms and did not associate with atopy status PMID: 19796196
    16. Significant associations of single nucleotide polymorphisms with wheeze in the past year were detected in only four genes (IL4R, TLR4, MS4A2, TLR9). Variants in IL4R and TLR4 were also related to allergen-specific IgE, but not for MS4A2 and TLR9. PMID: 20085599
    17. Gene expression profiling after stimulation via high-affinity Fcepsilon receptor I (FcepsilonRI), showed the transcriptional levels of several CC chemokines were markedly increased. PMID: 12393595
    18. Products of the beta gene may control the level of surface expression, influencing susceptibility to allergies. PMID: 12753743
    19. The data suggested that the Gly237Gly genotype of the Fc epsilon RI beta gene conferred genetic susceptibility to allergic asthma in Chinese, which affected the total plasma IgE levels in the allergic asthma patients. PMID: 12903039
    20. A statistically significant association was foundbetween atopy and FcERIint2 variant polymorphism FcERIint2 polymorphism is related to atopy and may influence its development. PMID: 15087090
    21. The genomic region encompassing the beta-chain has been linked to atopy and a number of polymorphisms within the FcepsilonRIbeta gene are associated with various atopic diseases. PMID: 15316148
    22. FcepsilonRI beta-chain gene expression is down-regulated by a transcription factor, MZF-1, adn its cofactor FHL-3. PMID: 15453830
    23. Single nucleotide polymorphisms (SNPs) in the Fc epsilon receptor I beta promoter are causally linked with atopy via regulation of Fc epsilon RI expression. PMID: 15528387
    24. The speed of allergic symptom generation depends on the degree of IgE Fc epsilon receptor type I receptor triggering. PMID: 17088130
    25. in the Korean general population, airway hyper-responsiveness is significantly associated with the E237G polymorphism of FcepsilonRI-beta, which results in an intolerant amino acid substitution PMID: 17430357
    26. FcepsilonRIbeta E237G allele may have a protective role in wheezing illness among Taiwanese schoolchildren, depending on airway oxidative stress levels. PMID: 18269668
    27. The -237T>G polymorphism may be associated with the rate of atopy, which in turn could increase the release of histamine from basophils and may lead to the development of the aspirin-intolerant chronic urticaria PMID: 18534082
    28. PLSCR1 is a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses PMID: 18579528
    29. Fcgr4 is a mouse IgE receptor that resembles macrophage MS4A2 protein in humans and promotes IgE-induced lung inflammation. PMID: 18949059
    30. A promoter-dependent mechanism with altered transcriptional regulation of FcepsilonRIbeta may be involved for its association with asthma. PMID: 19218813

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    MS4A family
  • 組織特異性:
    Found on the surface of mast cells and basophils.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7316

    OMIM: 147138

    KEGG: hsa:2206

    STRING: 9606.ENSP00000278888

    UniGene: Hs.386748



主站蜘蛛池模板: 无尺码精品产品网站| 在线观看国产精品乱码app| 精品一区二区三区在线播放视频| 亚洲va综合va国产产va中| 国产精品免费福利久久| 又硬又粗又大一区二区三区视频| 精品人妻无码一区二区三区| 国产黄在线观看免费观看不卡| 国产1卡2卡3卡4卡免费| 欧美野性肉体狂欢大派对| 成年女人永久免费观看视频| 在厨房拨开内裤进入在线视频| 欧美精品成人v高清视频| 国产精品一区二区av交换 | 四川丰满少妇被弄到高潮| 国产精品成人国产乱| 午夜福利视频极品国产83| av永久天堂一区| 男女性高爱潮免费网站| 免费观看羞羞视频网站| 人妻少妇精品视频无码综合| 成人无码专区免费播放三区| 成人无码精品一区二区三区亚洲区 | 少妇挑战黑人高潮惨叫| 成人无码α片在线观看不卡| 夜夜高潮天天爽欧美| 欧美黑人又粗又大高潮喷水 | 嫩草国产露脸精品国产软件| 久久这里只有精品首页| 美女极度色诱视频国产免费| 不卡无码人妻一区三区音频| 中文无码人妻有码人妻中文字幕 | 天堂资源中文| 乱色精品无码一区二区国产盗| 亚洲欧洲成人av每日更新| 亚洲成av大片大片在线播放| 精品国产在天天在线观看| 国产成人一区二区三区在线| 国内裸体无遮挡免费视频| 国产欧美在线亚洲一区| 伊人久久大香线蕉av色婷婷色|